{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:33:52Z","timestamp":1792424032098,"version":"4.5.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T00:00:00Z","timestamp":1556928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15GM116098"],"award-info":[{"award-number":["R15GM116098"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We reconstituted two biochemical processes that may contribute to UV-induced mutagenesis in vitro and analysed the mutational profiles in the products. One process is translesion synthesis (TLS) by DNA polymerases (Pol) \u03b4, \u03b7\u00a0and \u03b6, which creates C&amp;gt;T transitions at pyrimidine dimers by incorporating two dAMPs opposite of the dimers. The other process involves spontaneous deamination of cytosine, producing uracil in pyrimidine dimers, followed by monomerization of the dimers by secondary UV irradiation, and DNA synthesis by Pol \u03b4. The mutational spectrum resulting from deamination without translesion synthesis is similar to a mutational signature found in melanomas, suggesting that cytosine deamination encountered by the replicative polymerase has a prominent role in melanoma development. However, CC&amp;gt;TT dinucleotide substitution, which is also commonly observed in melanomas, was produced almost exclusively by TLS. We propose that both TLS-dependent and deamination-dependent mutational processes are likely involved in UV-induced melanoma development.<\/jats:p>","DOI":"10.1093\/nar\/gkz335","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T19:17:58Z","timestamp":1556133478000},"page":"6769-6782","source":"Crossref","is-referenced-by-count":22,"title":["Biochemical reconstitution of UV-induced mutational processes"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2942-3667","authenticated-orcid":false,"given":"Tomohiko","family":"Sugiyama","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Ohio University, Athens, OH 45701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Ohio University, Athens, OH 45701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,4]]},"reference":[{"key":"2020071623232320200_B1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1039\/C7PP00395A","article-title":"Formation of UV-induced DNA damage contributing to skin cancer development","volume":"17","author":"Cadet","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"2020071623232320200_B2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1011-1344(01)00206-8","article-title":"Direct and indirect effects of UV radiation on DNA and its components","volume":"63","author":"Ravanat","year":"2001","journal-title":"J. Photochem. Photobiol. B."},{"key":"2020071623232320200_B3","doi-asserted-by":"crossref","first-page":"9005","DOI":"10.1073\/pnas.87.22.9005","article-title":"Site and strand specificity of UVB mutagenesis in the SUP4-o gene of yeast","volume":"87","author":"Armstrong","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B4","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1073\/pnas.91.1.360","article-title":"UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement","volume":"91","author":"Nakazawa","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"2020071623232320200_B6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature"},{"key":"2020071623232320200_B7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1021\/bi00053a011","article-title":"In vivo evidence that UV-induced C\u2192T mutations at dipyrimidine sites could result from the replicative bypass of cis-syn cyclobutane dimers or their deamination products","volume":"32","author":"Jiang","year":"1993","journal-title":"Biochemistry"},{"key":"2020071623232320200_B8","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1021\/bi00458a038","article-title":"cis-syn thymine dimers are not absolute blocks to replication by DNA polymerase I of Escherichia coli in vitro","volume":"29","author":"Taylor","year":"1990","journal-title":"Biochemistry"},{"key":"2020071623232320200_B9","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1073\/pnas.53.5.1111","article-title":"Pyrimidine dimers in UV-irradiated poly dI:dC","volume":"53","author":"Setlow","year":"1965","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/1011-1344(92)85124-D","article-title":"Far-UV photochemistry and photosensitization of 2\u2032-deoxycytidylyl-(3\u2032-5\u2032)-thymidine: isolation and characterization of the main photoproducts","volume":"15","author":"Douki","year":"1992","journal-title":"J. Photochem. Photobiol. B"},{"key":"2020071623232320200_B11","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1021\/bi00616a003","article-title":"Photochemistry of cytosine derivatives. 1. Photochemistry of thymidylyl-(3\u2032 leads to 5\u2032)-deoxycytidine","volume":"17","author":"Liu","year":"1978","journal-title":"Biochemistry"},{"key":"2020071623232320200_B12","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/bi00061a009","article-title":"Kinetic analysis of the deamination reactions of cyclobutane dimers of thymidylyl-3\u2032,5\u2032-2\u2032-deoxycytidine and 2\u2032-deoxycytidylyl-3\u2032,5\u2032-thymidine","volume":"32","author":"Lemaire","year":"1993","journal-title":"Biochemistry"},{"key":"2020071623232320200_B13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1006\/jmbi.1998.2176","article-title":"Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo","volume":"284","author":"Tu","year":"1998","journal-title":"J. Mol. Biol."},{"key":"2020071623232320200_B14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1562\/2004-06-15-RA-201.1","article-title":"The photochemistry of thymidylyl-(3\u2032-5\u2032)-5-methyl-2\u2032-deoxycytidine in aqueous solution","volume":"81","author":"Celewicz","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"2020071623232320200_B15","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1021\/bi00462a015","article-title":"A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy","volume":"29","author":"Frederico","year":"1990","journal-title":"Biochemistry"},{"key":"2020071623232320200_B16","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1093\/emboj\/20.22.6520","article-title":"Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines","volume":"20","author":"Vaisman","year":"2001","journal-title":"EMBO J."},{"key":"2020071623232320200_B17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/nar\/gkm1023","article-title":"Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya","volume":"36","author":"Wardle","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2020071623232320200_B18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13072-015-0016-6","article-title":"Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond","volume":"8","author":"Breiling","year":"2015","journal-title":"Epigenet. Chromatin"},{"key":"2020071623232320200_B19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.biochem.74.082803.133250","article-title":"Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function","volume":"74","author":"Prakash","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"2020071623232320200_B20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.285.5425.263","article-title":"hRAD30 mutations in the variant form of xeroderma pigmentosum","volume":"285","author":"Johnson","year":"1999","journal-title":"Science"},{"key":"2020071623232320200_B21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/21447","article-title":"The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta","volume":"399","author":"Masutani","year":"1999","journal-title":"Nature"},{"key":"2020071623232320200_B22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/261593a0","article-title":"Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells","volume":"261","author":"Maher","year":"1976","journal-title":"Nature"},{"key":"2020071623232320200_B23","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1128\/MCB.13.7.4276","article-title":"Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts","volume":"13","author":"Wang","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"2020071623232320200_B24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/MCB.21.1.185-188.2001","article-title":"Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts","volume":"21","author":"Yu","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"2020071623232320200_B25","doi-asserted-by":"crossref","first-page":"18767","DOI":"10.1074\/jbc.M211838200","article-title":"Role of DNA polymerase eta in the UV mutation spectrum in human cells","volume":"278","author":"Stary","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2020071623232320200_B26","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.283.5404.1001","article-title":"Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta","volume":"283","author":"Johnson","year":"1999","journal-title":"Science"},{"key":"2020071623232320200_B27","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1093\/emboj\/19.12.3100","article-title":"Mechanisms of accurate translesion synthesis by human DNA polymerase eta","volume":"19","author":"Masutani","year":"2000","journal-title":"EMBO J."},{"key":"2020071623232320200_B28","first-page":"3094","article-title":"Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta","volume":"97","author":"Washington","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B29","doi-asserted-by":"crossref","first-page":"7447","DOI":"10.1074\/jbc.275.11.7447","article-title":"Fidelity of human DNA polymerase eta","volume":"275","author":"Johnson","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2020071623232320200_B30","doi-asserted-by":"crossref","first-page":"12093","DOI":"10.1073\/pnas.2134223100","article-title":"Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta","volume":"100","author":"Washington","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B31","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/35023030","article-title":"Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions","volume":"406","author":"Johnson","year":"2000","journal-title":"Nature"},{"key":"2020071623232320200_B32","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1101\/gad.1009802","article-title":"Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair","volume":"16","author":"Prakash","year":"2002","journal-title":"Genes Dev."},{"key":"2020071623232320200_B33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/geno.1999.5906","article-title":"Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta","volume":"60","author":"McDonald","year":"1999","journal-title":"Genomics"},{"key":"2020071623232320200_B34","doi-asserted-by":"crossref","first-page":"39678","DOI":"10.1074\/jbc.M005309200","article-title":"Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene","volume":"275","author":"Ohashi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2020071623232320200_B35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1097-2765(01)00278-7","article-title":"The Y-family of DNA polymerases","volume":"8","author":"Ohmori","year":"2001","journal-title":"Mol. Cell"},{"key":"2020071623232320200_B36","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1101\/gad.14.13.1642","article-title":"poliota, a remarkably error-prone human DNA polymerase","volume":"14","author":"Tissier","year":"2000","journal-title":"Genes Dev."},{"key":"2020071623232320200_B37","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1128\/MCB.20.19.7099-7108.2000","article-title":"Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota","volume":"20","author":"Zhang","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"2020071623232320200_B38","doi-asserted-by":"crossref","first-page":"30615","DOI":"10.1074\/jbc.M102694200","article-title":"Human DNA polymerase iota promiscuous mismatch extension","volume":"276","author":"Vaisman","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2020071623232320200_B39","doi-asserted-by":"crossref","first-page":"18083","DOI":"10.1073\/pnas.0605247103","article-title":"Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer","volume":"103","author":"Dumstorf","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B40","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1158\/0008-5472.CAN-06-3073","article-title":"Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations","volume":"67","author":"Wang","year":"2007","journal-title":"Cancer Res."},{"key":"2020071623232320200_B41","doi-asserted-by":"crossref","first-page":"11552","DOI":"10.1073\/pnas.0812548106","article-title":"DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients","volume":"106","author":"Ziv","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B42","doi-asserted-by":"crossref","first-page":"18219","DOI":"10.1073\/pnas.0910121106","article-title":"Highly error-free role of DNA polymerase eta in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells","volume":"106","author":"Yoon","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B43","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/382729a0","article-title":"Deoxycytidyl transferase activity of yeast REV1 protein","volume":"382","author":"Nelson","year":"1996","journal-title":"Nature"},{"key":"2020071623232320200_B44","doi-asserted-by":"crossref","first-page":"9555","DOI":"10.1128\/MCB.01671-06","article-title":"Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions","volume":"26","author":"Acharya","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"2020071623232320200_B45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mrfmmm.2005.03.005","article-title":"Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo","volume":"578","author":"Otsuka","year":"2005","journal-title":"Mutat. Res."},{"key":"2020071623232320200_B46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.molcel.2006.05.038","article-title":"REV1 protein interacts with PCNA: Significance of the REV1 BRCT domain in vitro and in vivo","volume":"23","author":"Guo","year":"2006","journal-title":"Mol. Cell"},{"key":"2020071623232320200_B47","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.dnarep.2008.12.006","article-title":"Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells","volume":"8","author":"Akagi","year":"2009","journal-title":"DNA Repair (Amst.)"},{"key":"2020071623232320200_B48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.dnarep.2017.08.011","article-title":"NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro","volume":"59","author":"Chen","year":"2017","journal-title":"DNA Repair (Amst.)"},{"key":"2020071623232320200_B49","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1073\/pnas.1222241110","article-title":"PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase delta, eta, and zeta activities","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2020071623232320200_B50","article-title":"Improved Pairwise Alignment of Genomic DNA","volume-title":"Computer Science and Engineering","author":"Harris","year":"2007","edition":"PhD. Thesis"},{"key":"2020071623232320200_B51","doi-asserted-by":"crossref","first-page":"107","DOI":"10.32614\/RJ-2016-007","article-title":"Stylometry with R: A package for computational text analysis","volume":"8","author":"Eder","year":"2016","journal-title":"R J."},{"key":"2020071623232320200_B52","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jmb.2009.07.048","article-title":"Acceleration of 5-methylcytosine deamination in cyclobutane dimers by G and its implications for UV-induced C-to-T mutation hotspots","volume":"392","author":"Cannistraro","year":"2009","journal-title":"J. Mol. Biol."},{"key":"2020071623232320200_B53","doi-asserted-by":"crossref","first-page":"26597","DOI":"10.1074\/jbc.M115.673301","article-title":"Rapid deamination of cyclobutane pyrimidine dimer photoproducts at TCG sites in a translationally and rotationally positioned nucleosome in vivo","volume":"290","author":"Cannistraro","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2020071623232320200_B54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/bi00167a001","article-title":"Structure and function of DNA photolyase","volume":"33","author":"Sancar","year":"1994","journal-title":"Biochemistry"},{"key":"2020071623232320200_B55","first-page":"555","article-title":"Photochemistry of model oligo- and polynucleotides VI. Photodimerization and its reversal in thymine dinucleotide analogues","volume":"61","author":"Sztumpf","year":"1962","journal-title":"Biochim. Biophys. Acta"},{"key":"2020071623232320200_B56","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(64)80223-0","article-title":"The ultraviolet photochemistry of Thymidylyl-(3\u2032-5\u2032)-Thymidine","volume":"9","author":"Johns","year":"1964","journal-title":"J. Mol. Biol."},{"key":"2020071623232320200_B57","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1039\/c3pp50078k","article-title":"Sequence-dependent thymine dimer formation and photoreversal rates in double-stranded DNA","volume":"12","author":"Law","year":"2013","journal-title":"Photochem. Photobiol. Sci."},{"key":"2020071623232320200_B58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/bies.950130206","article-title":"The \u2018A rule\u2019 of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions?","volume":"13","author":"Strauss","year":"1991","journal-title":"Bioessays"},{"key":"2020071623232320200_B59","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.molcel.2016.12.020","article-title":"Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork","volume":"65","author":"Choe","year":"2017","journal-title":"Mol. Cell"},{"key":"2020071623232320200_B60","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.molcel.2016.10.033","article-title":"Acetylation of PCNA sliding surface by eco1 promotes genome stability through homologous recombination","volume":"65","author":"Billon","year":"2017","journal-title":"Mol. Cell"},{"key":"2020071623232320200_B61","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.dnarep.2008.01.005","article-title":"Differential repair of UVB-induced cyclobutane pyrimidine dimers in cultured human skin cells and whole human skin","volume":"7","author":"Mouret","year":"2008","journal-title":"DNA Repair (Amst.)"},{"key":"2020071623232320200_B62","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1093\/nar\/20.21.5805","article-title":"An ultraviolet light-damaged DNA recognition protein absent in xeroderma pigmentosum group E cells binds selectively to pyrimidine (6-4) pyrimidone photoproducts","volume":"20","author":"Treiber","year":"1992","journal-title":"Nucleic Acids Res."},{"key":"2020071623232320200_B63","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature11273","article-title":"Chromatin organization is a major influence on regional mutation rates in human cancer cells","volume":"488","author":"Schuster-Bockler","year":"2012","journal-title":"Nature"},{"key":"2020071623232320200_B64","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/php.12646","article-title":"UV-Induced DNA damage and mutagenesis in chromatin","volume":"93","author":"Mao","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"2020071623232320200_B65","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1038\/s41467-018-05064-0","article-title":"ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma","volume":"9","author":"Mao","year":"2018","journal-title":"Nat. Commun."},{"key":"2020071623232320200_B66","doi-asserted-by":"crossref","first-page":"9327","DOI":"10.1021\/bi0602009","article-title":"DNA synthesis past a 5-methylC-containing cis-syn-cyclobutane pyrimidine dimer by yeast pol eta is highly nonmutagenic","volume":"45","author":"Vu","year":"2006","journal-title":"Biochemistry"},{"key":"2020071623232320200_B67","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/nar\/gkt1039","article-title":"A cyclobutane thymine-N4-methylcytosine dimer is resistant to hydrolysis but strongly blocks DNA synthesis","volume":"42","author":"Yamamoto","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2020071623232320200_B68","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/298189a0","article-title":"UV-induced mutation hotspots occur at DNA damage hotspots","volume":"298","author":"Brash","year":"1982","journal-title":"Nature"},{"key":"2020071623232320200_B69","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.dnarep.2014.07.012","article-title":"Remarkable induction of UV-signature mutations at the 3\u2032-cytosine of dipyrimidine sites except at 5\u2032-TCG-3\u2032 in the UVB-exposed skin epidermis of xeroderma pigmentosum variant model mice","volume":"22","author":"Ikehata","year":"2014","journal-title":"DNA Repair (Amst.)"},{"key":"2020071623232320200_B70","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1021\/jo00108a026","article-title":"Synthesis and photochemical cleavage of Cis-Syn pyrimidine cyclobutane dimer analogs","volume":"60","author":"Fenick","year":"1995","journal-title":"J. Org. Chem."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/13\/6769\/28980852\/gkz335.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/13\/6769\/28980852\/gkz335.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T20:11:20Z","timestamp":1663359080000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/13\/6769\/5485529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,4]]},"references-count":70,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2019,5,4]]},"published-print":{"date-parts":[[2019,7,26]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkz335","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7,26]]},"published":{"date-parts":[[2019,5,4]]}}}