{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:35:51Z","timestamp":1790411751499,"version":"4.1.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research","doi-asserted-by":"publisher","award":["BSC0302"],"award-info":[{"award-number":["BSC0302"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["GAP182"],"award-info":[{"award-number":["GAP182"]}],"id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,20]]},"DOI":"10.1093\/nar\/gkz371","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T15:23:21Z","timestamp":1556637801000},"page":"5852-5866","source":"Crossref","is-referenced-by-count":33,"title":["Myg1 exonuclease couples the nuclear and mitochondrial translational programs through RNA processing"],"prefix":"10.1093","volume":"47","author":[{"given":"Ritika","family":"Grover","sequence":"first","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research, Rafi Marg, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaunak A","family":"Burse","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research, Rafi Marg, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shambhavi","family":"Shankrit","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayush","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research, Rafi Marg, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritika","family":"Kirty","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Narta","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal","family":"Srivastav","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini Kumar","family":"Ray","sequence":"additional","affiliation":[{"name":"School of environmental Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Malik","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Vats","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajender K","family":"Motiani","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipi","family":"Thukral","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya Sinha","family":"Roy","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"School of environmental Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamurthy","family":"Natarajan","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitali","family":"Mukerji","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Pandey","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh S","family":"Gokhale","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"},{"name":"National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek T","family":"Natarajan","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Genomics and Integrative Biology, Mathura Road, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research, Rafi Marg, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"2019061905500083400_B1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tem.2012.06.006","article-title":"Transcriptional integration of mitochondrial biogenesis","volume":"23","author":"Scarpulla","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"2019061905500083400_B2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2011.06.051","article-title":"Resource the human mitochondrial transcriptome","volume":"146","author":"Mercer","year":"2011","journal-title":"Cell"},{"key":"2019061905500083400_B3","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1038\/sj.emboj.7600752","article-title":"Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells","volume":"24","author":"Rouquette","year":"2005","journal-title":"EMBO J."},{"key":"2019061905500083400_B4","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1080\/15384101.2015.1053672","article-title":"Mitochondrial ribosome assembly in health and disease","volume":"14","author":"Silva","year":"2015","journal-title":"Cell Cycle"},{"key":"2019061905500083400_B5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0962-8924(00)01738-4","article-title":"The nucleolus: an old factory with unexpected capabilities","volume":"10","author":"Olson","year":"2000","journal-title":"Trends Cell Biol."},{"key":"2019061905500083400_B6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cell.2009.01.019","article-title":"Review the many pathways of RNA degradation","volume":"136","author":"Houseley","year":"2009","journal-title":"Cell"},{"key":"2019061905500083400_B7","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.mib.2013.07.011","article-title":"Organelle transcriptomes: products of a deconstructed genome","volume":"16","author":"Small","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"2019061905500083400_B8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature18015","article-title":"Synchronized mitochondrial and cytosolic translation programs","volume":"533","author":"Couvillion","year":"2016","journal-title":"Nature"},{"key":"2019061905500083400_B9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1083\/jcb.201507125","article-title":"Mitochondrial RNA granules\u202f: Compartmentalizing mitochondrial gene expression","volume":"212","author":"Jourdain","year":"2016","journal-title":"J. Cell Biol."},{"key":"2019061905500083400_B10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.celrep.2013.09.036","article-title":"Resource mapping of mitochondrial RNA-Protein interactions by digital RNase footprinting","volume":"5","author":"Liu","year":"2013","journal-title":"Cell Rep."},{"key":"2019061905500083400_B11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.molcel.2013.08.011","article-title":"Resource the complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors","volume":"51","author":"Tafforeau","year":"2013","journal-title":"Mol. Cell"},{"key":"2019061905500083400_B12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.cmet.2014.03.013","article-title":"Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids","volume":"19","author":"Bogenhagen","year":"2014","journal-title":"Cell Metab."},{"key":"2019061905500083400_B13","doi-asserted-by":"crossref","first-page":"12469","DOI":"10.1093\/nar\/gkx902","article-title":"The MRPP1 \/ MRPP2 complex is a tRNA-maturation platform in human mitochondria","volume":"45","author":"Reinhard","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019061905500083400_B14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2010.06.035","article-title":"PNPASE regulates RNA import into mitochondria","volume":"142","author":"Wang","year":"2010","journal-title":"Cell"},{"key":"2019061905500083400_B15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cell.2018.04.017","article-title":"PNPT1 release from mitochondria during apoptosis article PNPT1 release from mitochondria during apoptosis triggers decay of poly (A) RNAs","volume":"174","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"2019061905500083400_B16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/s41556-017-0016-9","article-title":"EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation","volume":"20","author":"Silva","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"2019061905500083400_B17","doi-asserted-by":"crossref","first-page":"7750","DOI":"10.1093\/nar\/gkr470","article-title":"PDE12 removes mitochondrial RNA poly (A) tails and controls translation in human mitochondria","volume":"39","author":"Rorbach","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2019061905500083400_B18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.celrep.2014.03.035","article-title":"Functional genomic analysis of human mitochondrial RNA processing","volume":"7","author":"Wolf","year":"2015","journal-title":"Cell Rep."},{"key":"2019061905500083400_B19","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.cell.2016.09.052","article-title":"Article MOF acetyl transferase regulates transcription and respiration in mitochondria article MOF acetyl transferase regulates transcription and respiration in mitochondria","volume":"167","author":"Chatterjee","year":"2016","journal-title":"Cell"},{"key":"2019061905500083400_B20","first-page":"1","article-title":"A subcellular map of the human proteome","volume":"3321","author":"Thul","year":"2017","journal-title":"Science"},{"key":"2019061905500083400_B21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/BC20080086","article-title":"Characterization of MYG1 gene and protein\u202f: subcellular distribution and function Biology of the Cell","volume":"101","author":"Luuk","year":"2009","journal-title":"Biol. Cell"},{"key":"2019061905500083400_B22","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neurobiolaging.2007.01.014","article-title":"The role of mtDNA mutations in the pathogenesis of age-related hearing loss in mice carrying a mutator DNA polymerase gamma","volume":"29","author":"Someya","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"2019061905500083400_B23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cmet.2006.11.003","article-title":"Hypomorphic mutation in PGC1\u03b2 causes mitochondrial dysfunction and liver insulin resistance","volume":"4","author":"Vianna","year":"2007","journal-title":"Cell Metab."},{"key":"2019061905500083400_B24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbr.2009.10.005","article-title":"Myg1 -deficient mice display alterations in stress-induced responses and reduction of sex-dependent behavioural differences","volume":"207","author":"Philips","year":"2010","journal-title":"Behav. Brain Res."},{"key":"2019061905500083400_B25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1046\/j.1601-183x.2003.00047.x","article-title":"A screen for genes induced in the amygdaloid area during cat odor exposure","volume":"3","author":"K\u00f5ks","year":"2004","journal-title":"Genes Brain Behav."},{"key":"2019061905500083400_B26","first-page":"2","article-title":"MYG1, novel melanocyte related gene, has elevated expression in vitiligo","volume":"1","author":"Kingo","year":"2006","journal-title":"J. Dermatol. Sci."},{"key":"2019061905500083400_B27","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1093\/nar\/gkf470","article-title":"Metallo- b -lactamase fold within nucleic acids processing enzymes\u202f: the b -CASP family","volume":"30","author":"Callebaut","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"2019061905500083400_B28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0968-0004(97)01162-6","article-title":"A novel family of predicted phosphoesterases include Drosophila prune protein and Bacterial RecJ exonuclease","volume":"23","author":"Arvind","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"2019061905500083400_B29","doi-asserted-by":"crossref","first-page":"9613","DOI":"10.1073\/pnas.0901997106","article-title":"Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs","volume":"106","author":"Granneman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2019061905500083400_B30","doi-asserted-by":"crossref","first-page":"R8","DOI":"10.1186\/gb-2014-15-1-r8","article-title":"PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast","volume":"15","author":"Webb","year":"2014","journal-title":"Genome Biol."},{"key":"2019061905500083400_B31","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.molcel.2018.01.037","article-title":"Mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via article mitochondrial retrograde signaling in mammals is mediated by the transcriptional cofactor GPS2 via direct mitochondria-to-nucleus translocation","volume":"69","author":"Cardamone","year":"2018","journal-title":"Mol. Cell"},{"key":"2019061905500083400_B32","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1093\/nar\/gkx104","article-title":"Simultaneous processing and degradation of mitochondrial RNAs revealed by circularized RNA sequencing","volume":"45","author":"Kuznetsova","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2019061905500083400_B33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jdermsci.2013.04.026","article-title":"Correlation of increased MYG 1 expression and its promoter polymorphism with disease progression and higher susceptibility in vitiligo patients","volume":"71","author":"Dwivedi","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"2019061905500083400_B34","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/jid.2010.201","article-title":"Transcriptional upregulation of Nrf2-dependent phase II detoxification genes in the involved epidermis of vitiligo vulgaris","volume":"130","author":"Natarajan","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"2019061905500083400_B35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.jidsp.5640189","article-title":"In vivo and in vitro evidence for hydrogen peroxide (H 2 O 2) successful removal by a UVB-Activated Pseudocatalase","volume":"4","author":"Schallreuter","year":"1999","journal-title":"J. Invest. Dermatol. Symp. Proc."},{"key":"2019061905500083400_B36","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1523-1747.2001.00220.x","article-title":"Epidermal H2O2 accumulation alters tetrahydrobiopterin (6BH 4) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH 4 -dependent processes?","volume":"116","author":"Schallreuter","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"2019061905500083400_B37","doi-asserted-by":"crossref","first-page":"9860","DOI":"10.1038\/s41598-017-10253-w","article-title":"Mapping architectural and transcriptional alterations in non- lesional and lesional epidermis in vitiligo","volume":"7","author":"Singh","year":"2017","journal-title":"Nat. Sci. Rep."},{"key":"2019061905500083400_B38","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/nar\/gkv1003","article-title":"MitoCarta2. 0\u202f: an updated inventory of mammalian mitochondrial proteins","volume":"44","author":"Calvo","year":"2016","journal-title":"Nucleic Acid Res."},{"key":"2019061905500083400_B39","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cell.2007.08.037","article-title":"Functional specificity among ribosomal proteins regulates gene expression","volume":"131","author":"Komili","year":"2007","journal-title":"Cell"},{"key":"2019061905500083400_B40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.201706059","article-title":"Specialized ribosomes and specific ribosomal protein paralogs control translation of mitochondrial proteins","volume":"217","author":"Segev","year":"2018","journal-title":"J. Cell Biol."},{"key":"2019061905500083400_B41","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1261\/rna.2581711","article-title":"Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq","volume":"17","author":"Shepard","year":"2011","journal-title":"RNA"},{"key":"2019061905500083400_B42","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.aaa1193","article-title":"The structure of the human mitochondrial ribosome","volume":"348","author":"Amunts","year":"2015","journal-title":"Science"},{"key":"2019061905500083400_B43","doi-asserted-by":"crossref","first-page":"20140330","DOI":"10.1098\/rstb.2014.0330","article-title":"Endosymbiotic theories for eukaryote origin","volume":"370","author":"Martin","year":"2015","journal-title":"Philos. Trans. R. Soc. London."},{"key":"2019061905500083400_B44","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1034\/j.1600-0749.2003.00087.x","article-title":"Alterations of mitochondria in peripheral blood mononuclear cells of vitiligo patients","volume":"16","author":"Lucia","year":"2003","journal-title":"Pigment Cell Melanoma Res."},{"key":"2019061905500083400_B45","doi-asserted-by":"crossref","first-page":"13663","DOI":"10.1038\/s41598-017-13961-5","article-title":"Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin","volume":"7","author":"Lucia","year":"2017","journal-title":"Nat. Sci. Rep."},{"key":"2019061905500083400_B46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jdermsci.2009.02.004","article-title":"Ultrastructural and functional alterations of mitochondria in perilesional vitiligo skin","volume":"54","author":"Prignano","year":"2009","journal-title":"J. Dermatol. Sci."},{"key":"2019061905500083400_B47","doi-asserted-by":"crossref","first-page":"541230","DOI":"10.1155\/2014\/541230","article-title":"Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies","volume":"2014","author":"Pagano","year":"2014","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Nucleic Acids Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nar\/advance-article-pdf\/doi\/10.1093\/nar\/gkz371\/28602414\/gkz371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nar\/article-pdf\/47\/11\/5852\/28839420\/gkz371.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T07:46:56Z","timestamp":1569052016000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nar\/article\/47\/11\/5852\/5488530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,13]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,5,13]]},"published-print":{"date-parts":[[2019,6,20]]}},"URL":"https:\/\/doi.org\/10.1093\/nar\/gkz371","relation":{},"ISSN":["0305-1048","1362-4962"],"issn-type":[{"value":"0305-1048","type":"print"},{"value":"1362-4962","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6,20]]},"published":{"date-parts":[[2019,5,13]]}}}