{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:07:30Z","timestamp":1792062450258,"version":"4.4.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"14","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cellular senescence, an integral component of aging and cancer, arises in response to diverse triggers, including telomere attrition, macromolecular damage\u00a0and signaling from activated oncogenes. At present, senescent cells are identified by the combined presence of multiple traits, such as senescence-associated protein expression and secretion, DNA damage\u00a0and \u03b2-galactosidase activity; unfortunately, these traits are neither exclusively nor universally present in senescent cells. To identify robust shared markers of senescence, we have performed RNA-sequencing analysis across eight diverse models of senescence triggered in human diploid fibroblasts (WI-38, IMR-90) and endothelial cells (HUVEC, HAEC) by replicative exhaustion, exposure to ionizing radiation or doxorubicin, and expression of the oncogene HRASG12V. The intersection of the altered transcriptomes revealed 50 RNAs consistently elevated and 18 RNAs consistently reduced across all senescence models, including many protein-coding mRNAs and some non-coding RNAs. We propose that these shared transcriptome profiles will enable the identification of senescent cells in vivo, the investigation of their roles in aging and malignancy\u00a0and the development of strategies to target senescent cells therapeutically.<\/jats:p>","DOI":"10.1093\/nar\/gkz555","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T23:13:36Z","timestamp":1560381216000},"page":"7294-7305","source":"Crossref","is-referenced-by-count":312,"title":["Transcriptome signature of cellular senescence"],"prefix":"10.1093","volume":"47","author":[{"given":"Gabriel","family":"Casella","sequence":"first","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Munk","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Piao","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriyo","family":"De","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotb","family":"Abdelmohsen","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-3434","authenticated-orcid":false,"given":"Myriam","family":"Gorospe","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"2019101404285148400_B1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid cell strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp. 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