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Further, this role is not clear because these viruses have typically lower packing fractions than viruses encapsidating naked dsDNA. In addition, it has recently been shown that the major adenovirus condensing protein (polypeptide VII) is dispensable for genome encapsidation. Here, we study the morphology and mechanics of adenovirus particles with (Ad5-wt) and without (Ad5-VII-) protein VII. Ad5-VII-\u00a0particles are stiffer than Ad5-wt, but DNA-counterions revert this difference, indicating that VII screens repulsive DNA-DNA interactions. Consequently, its absence results in increased internal pressure. The core is slightly more ordered in the absence of VII and diffuses faster out of Ad5-VII\u2013 than Ad5-wt fractured particles. In Ad5-wt unpacked cores, dsDNA associates in bundles interspersed with VII-DNA clusters. These results indicate that protein VII condenses the adenovirus genome by combining direct clustering and promotion of bridging by other core proteins. This condensation modulates the virion internal pressure and DNA release from disrupted particles, which could be crucial to keep the genome protected inside the semi-disrupted capsid while traveling to the nuclear pore.<\/jats:p>","DOI":"10.1093\/nar\/gkz687","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T11:16:03Z","timestamp":1565176563000},"page":"9231-9242","source":"Crossref","is-referenced-by-count":49,"title":["Adenovirus major core protein condenses DNA in clusters and bundles, modulating genome release and capsid internal pressure"],"prefix":"10.1093","volume":"47","author":[{"given":"Natalia","family":"Mart\u00edn-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Condensed Matter Physics, Universidad Aut\u00f3noma de Madrid, Madrid 28049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Hernando-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Macromolecular Structures, Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), Madrid\u00a028049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela N","family":"Condezo","sequence":"additional","affiliation":[{"name":"Department of Macromolecular Structures, Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), Madrid\u00a028049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"P\u00e9rez-Illana","sequence":"additional","affiliation":[{"name":"Department of Macromolecular Structures, Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), Madrid\u00a028049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"\u0160iber","sequence":"additional","affiliation":[{"name":"Institute of Physics, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Reguera","sequence":"additional","affiliation":[{"name":"Departament de F\u00edsica de la Mat\u00e8ria Condensada, Facultat de F\u00edsica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e9s 1, 08028 Barcelona, Spain"},{"name":"Universitat de Barcelona Institute of Complex Systems (UBICS), 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philomena","family":"Ostapchuk","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-5222, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hearing","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-5222, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-175X","authenticated-orcid":false,"given":"Carmen","family":"San\u00a0Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Macromolecular Structures, Centro Nacional de Biotecnolog\u00eda (CNB-CSIC), Madrid\u00a028049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-3186","authenticated-orcid":false,"given":"Pedro J","family":"de\u00a0Pablo","sequence":"additional","affiliation":[{"name":"Department of Condensed Matter Physics, Universidad Aut\u00f3noma de Madrid, Madrid 28049, Spain"},{"name":"Instituto de F\u00edsica de la Materia Condensada (IFIMAC), Universidad Aut\u00f3noma de Madrid, Madrid\u00a028049, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"2019092221513378100_B1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/10409230802528488","article-title":"The major architects of chromatin: architectural proteins in bacteria, Archaea and Eukaryotes","volume":"43","author":"Luijsterburg","year":"2008","journal-title":"Crit. 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