{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:01:54Z","timestamp":1791986514393,"version":"4.4.0"},"reference-count":127,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM32335"],"award-info":[{"award-number":["GM32335"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RM1 GM130450"],"award-info":[{"award-number":["RM1 GM130450"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM51753"],"award-info":[{"award-number":["R01 GM51753"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1165135"],"award-info":[{"award-number":["APP1165135"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>When replication forks encounter template DNA lesions, the lesion is simply skipped in some cases. The resulting lesion-containing gap must be converted to duplex DNA to permit repair. Some gap filling occurs via template switching, a process that generates recombination-like branched DNA intermediates. The Escherichia coli Uup and RadD proteins function in different pathways to process the branched intermediates. Uup is a UvrA-like ABC family ATPase. RadD is a RecQ-like SF2 family ATPase. Loss of both functions uncovers frequent and RecA-independent deletion events in a plasmid-based assay. Elevated levels of crossing over and repeat expansions accompany these deletion events, indicating that many, if not most, of these events are associated with template switching in postreplication gaps as opposed to simple replication slippage. The deletion data underpin simulations indicating that multiple postreplication gaps may be generated per replication cycle. Both Uup and RadD bind to branched DNAs in vitro. RadD protein suppresses crossovers and Uup prevents nucleoid mis-segregation. Loss of Uup and RadD function increases sensitivity to ciprofloxacin. We present Uup and RadD as genomic guardians. These proteins govern two pathways for resolution of branched DNA intermediates such that potentially deleterious genome rearrangements arising from frequent template switching are averted.<\/jats:p>","DOI":"10.1093\/nar\/gkz960","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:01:00Z","timestamp":1571270460000},"source":"Crossref","is-referenced-by-count":8,"title":["Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins"],"prefix":"10.1093","author":[{"given":"Zachary J","family":"Romero","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin-Madison, Madison, WI\u00a053706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Molecular Horizons Institute and School of Chemistry, University of Wollongong, Wollongong, Australia"},{"name":"Illawarra Health and Medical Research Institute, Wollongong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S","family":"Henrikus","sequence":"additional","affiliation":[{"name":"Molecular Horizons Institute and School of Chemistry, University of Wollongong, Wollongong, Australia"},{"name":"Illawarra Health and Medical Research Institute, Wollongong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie H","family":"Chen","sequence":"additional","affiliation":[{"name":"Biotechnology Program, North Carolina State University, Raleigh, NC 27695, USA"},{"name":"Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Biology and Rosenstiel Center, Brandeis University, Waltham, MA\u00a002453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander E","family":"Ferrazzoli","sequence":"additional","affiliation":[{"name":"Department of Biology and Rosenstiel Center, Brandeis University, Waltham, MA\u00a002453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin-Madison, Madison, WI\u00a053706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu","family":"Chitteni-Pattu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin-Madison, Madison, WI\u00a053706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine M","family":"van\u00a0Oijen","sequence":"additional","affiliation":[{"name":"Molecular Horizons Institute and School of Chemistry, University of Wollongong, Wollongong, Australia"},{"name":"Illawarra Health and Medical Research Institute, Wollongong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T","family":"Lovett","sequence":"additional","affiliation":[{"name":"Department of Biology and Rosenstiel Center, Brandeis University, Waltham, MA\u00a002453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Robinson","sequence":"additional","affiliation":[{"name":"Molecular Horizons Institute and School of Chemistry, University of Wollongong, Wollongong, Australia"},{"name":"Illawarra Health and Medical Research Institute, Wollongong, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Wisconsin-Madison, Madison, WI\u00a053706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2019103013460943300_B1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/emboj\/16.2.430","article-title":"DNA double-strand breaks caused by replication arrest","volume":"16","author":"Michel","year":"1997","journal-title":"EMBO J."},{"key":"2019103013460943300_B2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-2443.1998.00175.x","article-title":"A broadening view of recombinational DNA repair in bacteria","volume":"3","author":"Cox","year":"1998","journal-title":"Genes Cells"},{"key":"2019103013460943300_B3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35003501","article-title":"The importance of repairing stalled replication forks","volume":"404","author":"Cox","year":"2000","journal-title":"Nature"},{"key":"2019103013460943300_B4","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1073\/pnas.131009198","article-title":"Single-strand interruptions in replicating chromosomes cause double-strand breaks","volume":"98","author":"Kuzminov","year":"2001","journal-title":"Proc. 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