{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:28:07Z","timestamp":1792232887072,"version":"4.4.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":72,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Cancer Institute Cancer Center Support","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}]},{"DOI":"10.13039\/100001033","name":"Jane Coffin Childs Memorial Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA207204"],"award-info":[{"award-number":["R01CA207204"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["6577\u201319"],"award-info":[{"award-number":["6577\u201319"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acute myeloid leukemia (AML) is driven by numerous molecular events that contribute to disease progression. Herein, we identify hnRNP K overexpression as a recurrent abnormality in AML that negatively correlates with patient survival. Overexpression of hnRNP K in murine fetal liver cells results in altered self-renewal and differentiation potential. Further, murine transplantation models reveal that hnRNP K overexpression results in myeloproliferation in vivo. Mechanistic studies expose a direct functional relationship between hnRNP K and RUNX1\u2014a master transcriptional regulator of hematopoiesis often dysregulated in leukemia. Molecular analyses show that overexpression of hnRNP K results in an enrichment of an alternatively spliced isoform of RUNX1 lacking exon 4. Our work establishes hnRNP K\u2019s oncogenic potential in influencing myelogenesis through its regulation of RUNX1 splicing and subsequent transcriptional activity.<\/jats:p>","DOI":"10.1093\/narcan\/zcac039","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T07:25:53Z","timestamp":1670570753000},"source":"Crossref","is-referenced-by-count":12,"title":["Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered <i>Runx1<\/i> splicing"],"prefix":"10.1093","volume":"4","author":[{"given":"Marisa J L","family":"Aitken","sequence":"first","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"},{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4667-4823","authenticated-orcid":false,"given":"Prerna","family":"Malaney","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"},{"name":"Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth , Hanover, NH, USA; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley M","family":"Herbrich","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"},{"name":"The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences , Houston , TX , USA"},{"name":"Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Benitez","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley\u00a0G","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxian","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1144-3344","authenticated-orcid":false,"given":"Rodrigo","family":"Jacamo","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Health Professions, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"},{"name":"Baylor College of Medicine , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd\u00a0M","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven\u00a0M","family":"Kornblau","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kanagal-Shamanna","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos\u00a0E","family":"Bueso-Ramos","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9225-200X","authenticated-orcid":false,"given":"Sean\u00a0M","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston , TX , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"2022120907244113000_B1","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMoa1614359","article-title":"Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation","volume":"377","author":"Stone","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"2022120907244113000_B2","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1056\/NEJMoa1902688","article-title":"Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML","volume":"381","author":"Perl","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"2022120907244113000_B3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1182\/blood-2018-08-869008","article-title":"Molecular remission and response patterns in patients with mutant-IDH2 acute myeloid leukemia treated with enasidenib","volume":"133","author":"Stein","year":"2019","journal-title":"Blood"},{"key":"2022120907244113000_B4","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1056\/NEJMoa1716984","article-title":"Durable remissions with Ivosidenib in IDH1-mutated relapsed or refractory AML","volume":"378","author":"DiNardo","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"2022120907244113000_B5","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1056\/NEJMoa1103283","article-title":"Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts","volume":"365","author":"Papaemmanuil","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"2022120907244113000_B6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ng.1031","article-title":"Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes","volume":"44","author":"Graubert","year":"2011","journal-title":"Nat. Genet."},{"key":"2022120907244113000_B7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature10496","article-title":"Frequent pathway mutations of splicing machinery in myelodysplasia","volume":"478","author":"Yoshida","year":"2011","journal-title":"Nature"},{"key":"2022120907244113000_B8","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.4416","article-title":"The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells","volume":"23","author":"Vu","year":"2017","journal-title":"Nat. Med."},{"key":"2022120907244113000_B9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nm.2187","article-title":"Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia","volume":"16","author":"Kharas","year":"2010","journal-title":"Nat. Med."},{"key":"2022120907244113000_B10","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fonc.2019.00692","article-title":"Transcriptomic analysis identifies RNA binding proteins as putative regulators of myelopoiesis and leukemia","volume":"9","author":"Saha","year":"2019","journal-title":"Front. Oncol."},{"key":"2022120907244113000_B11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccell.2019.01.010","article-title":"Targeting an RNA-binding protein network in acute myeloid leukemia","volume":"35","author":"Wang","year":"2019","journal-title":"Cancer Cell"},{"key":"2022120907244113000_B12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/sj.bjc.6603349","article-title":"Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer","volume":"95","author":"Carpenter","year":"2006","journal-title":"Br. J. Cancer"},{"key":"2022120907244113000_B13","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/cdd.2010.24","article-title":"The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients","volume":"17","author":"Chen","year":"2010","journal-title":"Cell Death Differ."},{"key":"2022120907244113000_B14","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1245\/s10434-010-1121-1","article-title":"Higher expression of the heterogeneous nuclear ribonucleoprotein k in melanoma","volume":"17","author":"Wen","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"2022120907244113000_B15","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/sj.bjc.6605057","article-title":"Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer","volume":"100","author":"Barboro","year":"2009","journal-title":"Br. J. Cancer"},{"key":"2022120907244113000_B16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/ijc.24744","article-title":"Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53","volume":"126","author":"Zhou","year":"2010","journal-title":"Int. J. Cancer"},{"key":"2022120907244113000_B17","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1182\/blood-2005-09-3732","article-title":"A MAPK\/HNRPK pathway controls BCR\/ABL oncogenic potential by regulating MYC mRNA translation","volume":"107","author":"Notari","year":"2006","journal-title":"Blood"},{"key":"2022120907244113000_B18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/jnci\/djz078","article-title":"Uncovering the role of hnRNP K, an RNA-binding protein, in B-cell lymphomas","volume":"112","author":"Gallardo","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"2022120907244113000_B19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2217\/fon.10.158","article-title":"RUNX1 translocations and fusion genes in malignant hemopathies","volume":"7","author":"De\u00a0Braekeleer","year":"2011","journal-title":"Future Oncol."},{"key":"2022120907244113000_B20","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1038\/leu.2016.126","article-title":"RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features","volume":"30","author":"Gaidzik","year":"2016","journal-title":"Leukemia"},{"key":"2022120907244113000_B21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s43042-021-00179-4","article-title":"RUNX1 gene expression in Egyptian acute myeloid leukemia patients: may it have therapeutic implications","volume":"22","author":"Said","year":"2021","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"2022120907244113000_B22","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/s41551-019-0387-2","article-title":"A quantitative analysis of heterogeneities and hallmarks in acute myelogenous leukaemia","volume":"3","author":"Hu","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"2022120907244113000_B23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1101\/gad.1771409","article-title":"Mouse models of human AML accurately predict chemotherapy response","volume":"23","author":"Zuber","year":"2009","journal-title":"Genes Dev."},{"key":"2022120907244113000_B24","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nature22370","article-title":"Haematopoietic stem and progenitor cells from human pluripotent stem cells","volume":"545","author":"Sugimura","year":"2017","journal-title":"Nature"},{"key":"2022120907244113000_B25","first-page":"373","article-title":"The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor","volume":"14","author":"Zhang","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"2022120907244113000_B26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"key":"2022120907244113000_B27","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1128\/jvi.70.8.5701-5705.1996","article-title":"The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses","volume":"70","author":"Naviaux","year":"1996","journal-title":"J. Virol."},{"key":"2022120907244113000_B28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1535-6108(02)00047-8","article-title":"Dissecting p53 tumor suppressor functions in vivo","volume":"1","author":"Schmitt","year":"2002","journal-title":"Cancer Cell"},{"key":"2022120907244113000_B29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"2022120907244113000_B30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nmeth.4324","article-title":"Differential analysis of RNA-seq incorporating quantification uncertainty","volume":"14","author":"Pimentel","year":"2017","journal-title":"Nat. Methods"},{"key":"2022120907244113000_B31","doi-asserted-by":"crossref","first-page":"e00175-18","DOI":"10.1128\/MCB.00175-18","article-title":"Poly(C)-binding protein Pcbp2 enables differentiation of definitive erythropoiesis by directing functional splicing of the Runx1 transcript","volume":"38","author":"Ghanem","year":"2018","journal-title":"Mol. Cell. Biol."},{"key":"2022120907244113000_B32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ymeth.2022.10.009","article-title":"Assessing the role of intrinsic disorder in RNA-binding protein function: hnRNP K as a case study","volume":"208","author":"Malaney","year":"2022","journal-title":"Methods"},{"key":"2022120907244113000_B33","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2022120907244113000_B34","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2141.2005.05445.x","article-title":"Del (9q) AML: clinical and cytological characteristics and prognostic implications","volume":"129","author":"Peniket","year":"2005","journal-title":"Br. J. Haematol."},{"key":"2022120907244113000_B35","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1182\/blood-2013-01-479188","article-title":"Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia","volume":"122","author":"Kronke","year":"2013","journal-title":"Blood"},{"key":"2022120907244113000_B36","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.ccell.2015.09.001","article-title":"hnRNP K is a haploinsufficient tumor suppressor that regulates proliferation and differentiation programs in hematologic malignancies","volume":"28","author":"Gallardo","year":"2015","journal-title":"Cancer Cell"},{"key":"2022120907244113000_B37","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","article-title":"Functional genomic landscape of acute myeloid leukaemia","volume":"562","author":"Tyner","year":"2018","journal-title":"Nature"},{"key":"2022120907244113000_B38","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Research","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"2022120907244113000_B39","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMc1608739","article-title":"Genomic Classification in Acute Myeloid Leukemia","volume":"375","author":"Papaemmanuil","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2022120907244113000_B40","doi-asserted-by":"crossref","first-page":"10302","DOI":"10.1073\/pnas.92.22.10302","article-title":"The purification and characterization of fetal liver hematopoietic stem cells","volume":"92","author":"Morrison","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2022120907244113000_B41","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2022120907244113000_B42","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1182\/blood-2013-08-521252","article-title":"Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice","volume":"123","author":"Komeno","year":"2014","journal-title":"Blood"},{"key":"2022120907244113000_B43","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1038\/sj.onc.1210067","article-title":"Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions","volume":"26","author":"Nanjundan","year":"2007","journal-title":"Oncogene"},{"key":"2022120907244113000_B44","first-page":"164","article-title":"Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein","volume":"12","author":"Matunis","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"2022120907244113000_B45","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1093\/nar\/gks504","article-title":"Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation","volume":"40","author":"Cao","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2022120907244113000_B46","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/jmcb\/mjaa019","article-title":"RUNX1-205, a novel splice variant of the human RUNX1 gene, has blockage effect on mesoderm-hemogenesis transition and promotion effect during the late stage of hematopoiesis","volume":"12","author":"Sun","year":"2020","journal-title":"J. Mol. Cell Biol."},{"key":"2022120907244113000_B47","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1128\/MCB.00597-06","article-title":"AML1\/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1\/RUNX1 by the anaphase-promoting complex","volume":"26","author":"Biggs","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"2022120907244113000_B48","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nm.2187","article-title":"Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia","volume":"16","author":"Kharas","year":"2010","journal-title":"Nat. Med."},{"key":"2022120907244113000_B49","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature24678","article-title":"Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control","volume":"552","author":"Barbieri","year":"2017","journal-title":"Nature"},{"key":"2022120907244113000_B50","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2011.01.004","article-title":"Densely interconnected transcriptional circuits control cell states in human hematopoiesis","volume":"144","author":"Novershtern","year":"2011","journal-title":"Cell"},{"key":"2022120907244113000_B51","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3324\/haematol.13299","article-title":"Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling","volume":"94","author":"Verhaak","year":"2009","journal-title":"Haematologica"},{"key":"2022120907244113000_B52","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1101\/gad.1632608","article-title":"Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev."},{"key":"2022120907244113000_B53","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/s41467-019-10102-6","article-title":"The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription","volume":"10","author":"Malik","year":"2019","journal-title":"Nat. Commun."},{"key":"2022120907244113000_B54","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41467-018-03513-4","article-title":"RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia","volume":"9","author":"Cheng","year":"2018","journal-title":"Nat. Commun."},{"key":"2022120907244113000_B55","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/2211-5463.13210","article-title":"Crosstalk between hnRNP K and SET in ATRA-induced differentiation in acute promyelocytic leukemia","volume":"11","author":"Padovani","year":"2021","journal-title":"FEBS Open Bio"},{"key":"2022120907244113000_B56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/BJ20140358","article-title":"hnRNP K in PU.1-containing complexes recruited at the CD11b promoter: a distinct role in modulating granulocytic and monocytic differentiation of AML-derived cells","volume":"463","author":"Nika","year":"2014","journal-title":"Biochem. J."}],"container-title":["NAR Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/narcancer\/article-pdf\/4\/4\/zcac039\/47756352\/zcac039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/narcancer\/article-pdf\/4\/4\/zcac039\/47756352\/zcac039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T07:26:26Z","timestamp":1670570786000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/narcancer\/article\/doi\/10.1093\/narcan\/zcac039\/6884716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,28]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,9,28]]}},"URL":"https:\/\/doi.org\/10.1093\/narcan\/zcac039","relation":{},"ISSN":["2632-8674"],"issn-type":[{"value":"2632-8674","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,9,28]]},"article-number":"zcac039"}}