{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:44:04Z","timestamp":1790516644238,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Health"},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 113407-01"],"award-info":[{"award-number":["R01 113407-01"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health Allergy and Infectious Disease","award":["R56AI147684-01"],"award-info":[{"award-number":["R56AI147684-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human T-lymphotropic virus type I (HTLV-I) infects CD4+ T-cells resulting in a latent, life-long infection in patients. Crosstalk between oncogenic viral factors results in the transformation of the host cell into an aggressive cancer, adult T-cell leukemia\/lymphoma (ATL). ATL has a poor prognosis with no currently available effective treatments, urging the development of novel therapeutic strategies. Recent evidence exploring those mechanisms contributing to ATL highlights the viral anti-sense gene HTLV-I bZIP factor (HBZ) as a tumor driver and a potential therapeutic target. In this work, a series of zinc-finger protein (ZFP) repressors were designed to target within the HTLV-I promoter that drives HBZ expression at highly conserved sites covering a wide range of HTLV-I genotypes. ZFPs were identified that potently suppressed HBZ expression and resulted in a significant reduction in the proliferation and viability of a patient-derived ATL cell line with the induction of cell cycle arrest and apoptosis. These data encourage the development of this novel ZFP strategy as a targeted modality to inhibit the molecular driver of ATL, a possible next-generation therapeutic for aggressive HTLV-I associated malignancies.<\/jats:p>","DOI":"10.1093\/narcan\/zcac046","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T16:39:20Z","timestamp":1673455160000},"source":"Crossref","is-referenced-by-count":7,"title":["Targeted zinc-finger repressors to the oncogenic HBZ gene inhibit adult T-cell leukemia (ATL) proliferation"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-9609","authenticated-orcid":false,"given":"Tristan A","family":"Scott","sequence":"first","affiliation":[{"name":"Center for Gene Therapy, City of Hope \u2013 Beckman Research Institute and Hematological Malignancy and Stem Cell Transplantation Institute at the City of Hope. 1500 E. Duarte Rd. , Duarte , CA \u00a091010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Citradewi","family":"Soemardy","sequence":"additional","affiliation":[{"name":"Center for Gene Therapy, City of Hope \u2013 Beckman Research Institute and Hematological Malignancy and Stem Cell Transplantation Institute at the City of Hope. 1500 E. Duarte Rd. , Duarte , CA \u00a091010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslyn\u00a0M","family":"Ray","sequence":"additional","affiliation":[{"name":"Center for Gene Therapy, City of Hope \u2013 Beckman Research Institute and Hematological Malignancy and Stem Cell Transplantation Institute at the City of Hope. 1500 E. Duarte Rd. , Duarte , CA \u00a091010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin\u00a0V","family":"Morris","sequence":"additional","affiliation":[{"name":"Menzies Health Institute Queensland, School of Pharmacy and Medical Science, Griffith University , Gold Coast Campus 4222, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"2024032320594169400_B1","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"2024032320594169400_B2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10428190400007607","article-title":"Expression of CCR4 in adult T-cell leukemia","volume":"46","author":"Yoshie","year":"2005","journal-title":"Leuk. 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