{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:42:08Z","timestamp":1785829328326,"version":"3.56.0"},"reference-count":193,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM122976"],"award-info":[{"award-number":["GM122976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wright State University Biomedical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extrachromosomal circular DNAs (eccDNAs) are produced from all regions of the eucaryotic genome. We used inverse PCR of non-B microsatellites capable of forming hairpin, triplex, quadruplex and AT-rich structures integrated at a common ectopic chromosomal site to show that these non-B DNAs generate highly mutagenized eccDNAs by replication-dependent mechanisms. Mutagenesis occurs within the non-B DNAs and extends several kilobases bidirectionally into flanking and nonallelic DNA. Each non-B DNA exhibits a different pattern of mutagenesis, while sister clones containing the same non-B DNA also display distinct patterns of recombination, microhomology-mediated template switching and base substitutions. Mutations include mismatches, short duplications, long nontemplated insertions, large deletions and template switches to sister chromatids and nonallelic chromosomes. Drug-induced replication stress or the depletion of DNA repair factors Rad51, the COPS2 signalosome subunit or POL\u03b7 change the pattern of template switching and alter the eccDNA mutagenic profiles. We propose an asynchronous capture model based on break-induced replication from microsatellite-induced DNA double strand breaks to account for the generation and circularization of mutagenized eccDNAs and the appearance of genomic homologous recombination deficiency (HRD) scars. These results may help to explain the appearance of tumor eccDNAS and their roles in neoantigen production, oncogenesis and resistance to chemotherapy.<\/jats:p>","DOI":"10.1093\/narcan\/zcae027","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T12:48:05Z","timestamp":1716554885000},"source":"Crossref","is-referenced-by-count":7,"title":["Microsatellite break-induced replication generates highly mutagenized extrachromosomal circular DNAs"],"prefix":"10.1093","volume":"6","author":[{"given":"Rujuta Yashodhan","family":"Gadgil","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton , OH\u00a045435,\u00a0 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"S Dean","family":"Rider","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton , OH\u00a045435,\u00a0 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resha","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton , OH\u00a045435,\u00a0 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venicia","family":"Alhawach","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton , OH\u00a045435,\u00a0 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0C","family":"Hitch","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton , OH\u00a045435,\u00a0 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-785X","authenticated-orcid":false,"given":"Michael","family":"Leffak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University , Dayton , OH\u00a045435,\u00a0 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"2024060810425517900_B1","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.3390\/ijms19103255","article-title":"Detours to replication: functions of specialized DNA polymerases during oncogene-induced replication stress","volume":"19","author":"Tsao","year":"2018","journal-title":"Int. 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