{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:05:53Z","timestamp":1792623953824,"version":"4.5.0"},"reference-count":159,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":85,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["ES029518"],"award-info":[{"award-number":["ES029518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["ES028949"],"award-info":[{"award-number":["ES028949"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA238061"],"award-info":[{"award-number":["CA238061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA236911"],"award-info":[{"award-number":["CA236911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AG069740"],"award-info":[{"award-number":["AG069740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["ES032522"],"award-info":[{"award-number":["ES032522"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["NSF-1841811"],"award-info":[{"award-number":["NSF-1841811"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Legoretta Cancer Center Endowment Fund"},{"DOI":"10.13039\/100016419","name":"Breast Cancer Research Foundation of Alabama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016419","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mitchell Cancer Institute Molecular & Metabolic Oncology Program Development Fund"},{"name":"Legoretta Cancer Center Endowment Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Poly(ADP-ribose) polymerases 1 and 2 (PARP1\/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a post-translational protein modification, in response to DNA damage or replication stress. Here, we find that replication-dependent and PARP1\/PARP2-mediated PARylation recruits the base excision repair (BER)\/single-strand break repair (SSBR) scaffold protein XRCC1 and the associated factors DNA polymerase \u03b2 (POLB), aprataxin (APTX), and DNA ligase isoform 3 (LIG3). Further, these BER\/SSBR proteins promote resistance to inhibitors of PARP1\/PARP2 and PARG, as loss of these proteins sensitizes glioblastoma and ovarian cancer cells to each. In addition, depletion of these replication-associated BER\/SSBR factors leads to enhanced PAR levels and PARG inhibitor-induced activation of the ATR\/CHK1 S-phase checkpoint kinases. Both PARG inhibition and ATR inhibition lead to elevated ATM- and DNA-PK-dependent KAP1 phosphorylation. In turn, inhibition of either ATR or CHK1 enhances the cellular response to PARG inhibitors. Finally, inhibition of the ATR regulators PRMT1 or PRMT5 synergizes with PARG inhibition, implicating replication-associated BER\/SSBR and PARylation in the activation of the PRMT1\/PRMT5\/ATR axis. This study highlights the role of BER\/SSBR in protecting the cell during S-phase to suppress PARylation-induced checkpoint activation, which may suggest a potential intervention strategy for PARG inhibitor-resistant tumors.<\/jats:p>","DOI":"10.1093\/narcan\/zcaf057","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:08:39Z","timestamp":1765544919000},"source":"Crossref","is-referenced-by-count":6,"title":["Replication-associated base excision repair\/single-strand break repair regulates PARG inhibitor response via the PRMT1\/PRMT5\/ATR axis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-1500","authenticated-orcid":false,"given":"Md","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Mitchell Cancer Institute, University of South Alabama , Mobile, AL 36604 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0474-7414","authenticated-orcid":false,"given":"Wynand P","family":"Roos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Maruf","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Q","family":"Al-Rahahleh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libby A","family":"Beers","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte R","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahrie T","family":"Langham","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boyang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Mitchell Cancer Institute, University of South Alabama , Mobile, AL 36604 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Hayat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Mitchell Cancer Institute, University of South Alabama , Mobile, AL 36604 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingming","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Mitchell Cancer Institute, University of South Alabama , Mobile, AL 36604 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A","family":"Koczor","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Mitchell Cancer Institute, University of South Alabama , Mobile, AL 36604 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie E","family":"Migaud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Mitchell Cancer Institute, University of South Alabama , Mobile, AL 36604 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-3563","authenticated-orcid":false,"given":"Robert W","family":"Sobol","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Mitchell Cancer Institute, University of South Alabama , Mobile, AL 36604 ,","place":["United States"]},{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University , Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"2026020905314940300_B1","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.2741\/2909","article-title":"The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases","volume":"13","author":"Hassa","year":"2008","journal-title":"Front Biosci"},{"key":"2026020905314940300_B2","doi-asserted-by":"publisher","first-page":"102930","DOI":"10.1016\/j.dnarep.2020.102930","article-title":"NAD+-mediated regulation of mammalian base excision repair","volume":"93","author":"Saville","year":"2020","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev.bi.54.070185.000445","article-title":"ADP-ribosylation","volume":"54","author":"Ueda","year":"1985","journal-title":"Annu Rev Biochem"},{"key":"2026020905314940300_B4","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1093\/emboj\/cdg209","article-title":"Functional aspects of protein mono-ADP-ribosylation","volume":"22","author":"Corda","year":"2003","journal-title":"EMBO J"},{"key":"2026020905314940300_B5","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrm1963","article-title":"Poly(ADP-ribose): novel functions for an old molecule","volume":"7","author":"Schreiber","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026020905314940300_B6","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.1016\/j.molcel.2024.10.024","article-title":"PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)","volume":"84","author":"Langelier","year":"2024","journal-title":"Mol Cell"},{"key":"2026020905314940300_B7","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.3390\/cancers13092042","article-title":"The PARP enzyme family and the hallmarks of cancer part 1","volume":"13","author":"Demeny","year":"2021","journal-title":"Cancers"},{"key":"2026020905314940300_B8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cels.2023.04.007","article-title":"A multi-scale map of protein assemblies in the DNA damage response","volume":"14","author":"Kratz","year":"2023","journal-title":"Cell Syst"},{"key":"2026020905314940300_B9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.dnarep.2014.09.004","article-title":"ARTD1 (PARP1) activation and NAD+ in DNA repair and cell death","volume":"23","author":"Fouquerel","year":"2014","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B10","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1016\/j.celrep.2014.08.036","article-title":"ARTD1\/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion","volume":"8","author":"Fouquerel","year":"2014","journal-title":"Cell Rep"},{"key":"2026020905314940300_B11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nature06420","article-title":"Poly(ADP-ribose)-binding zinc finger motifs in DNA repair\/checkpoint proteins","volume":"451","author":"Ahel","year":"2008","journal-title":"Nature"},{"key":"2026020905314940300_B12","doi-asserted-by":"publisher","first-page":"8129","DOI":"10.1093\/nar\/gkx565","article-title":"The role of poly ADP-ribosylation in the first wave of DNA damage response","volume":"45","author":"Liu","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B13","doi-asserted-by":"publisher","first-page":"109917","DOI":"10.1016\/j.celrep.2021.109917","article-title":"Temporal dynamics of base excision\/single-strand break repair protein complex assembly\/disassembly are modulated by the PARP\/NAD+\/SIRT6 axis","volume":"37","author":"Koczor","year":"2021","journal-title":"Cell Rep"},{"key":"2026020905314940300_B14","doi-asserted-by":"publisher","first-page":"103845","DOI":"10.1016\/j.dnarep.2025.103845","article-title":"Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage","volume":"150","author":"Al-Rahahleh","year":"2025","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B15","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/em.22623","article-title":"Poly-ADP-ribosylation dynamics, signaling, and analysis","volume":"65","author":"Al-Rahahleh","year":"2024","journal-title":"Environ and Mol Mutagen"},{"key":"2026020905314940300_B16","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.dnarep.2011.08.012","article-title":"PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro","volume":"10","author":"Liu","year":"2011","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B17","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1073\/pnas.1209507110","article-title":"Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair","volume":"110","author":"Robu","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020905314940300_B18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.tibs.2013.03.002","article-title":"Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks","volume":"38","author":"Pines","year":"2013","journal-title":"Trends Biochem Sci"},{"key":"2026020905314940300_B19","doi-asserted-by":"publisher","first-page":"5822","DOI":"10.1038\/s41467-024-50158-7","article-title":"PARG is essential for Pol\u03b8-mediated DNA end-joining by removing repressive poly-ADP-ribose marks","volume":"15","author":"Vekariya","year":"2024","journal-title":"Nat Commun"},{"key":"2026020905314940300_B20","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.dnarep.2007.01.009","article-title":"A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification","volume":"6","author":"Almeida","year":"2007","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B21","first-page":"2546","article-title":"Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin","volume":"45","author":"Hanzlikova","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B22","doi-asserted-by":"publisher","first-page":"5597","DOI":"10.1128\/MCB.02248-06","article-title":"Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase","volume":"27","author":"Fisher","year":"2007","journal-title":"Mol Cell Biol"},{"key":"2026020905314940300_B23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/bs.mie.2024.07.011","article-title":"AP endonuclease 1: biological updates and advances in activity analysis","volume":"705","author":"Almeida","year":"2024","journal-title":"Methods Enzymol"},{"key":"2026020905314940300_B24","doi-asserted-by":"publisher","first-page":"e0124269","DOI":"10.1371\/journal.pone.0124269","article-title":"Mammalian base excision repair: functional partnership between PARP-1 and APE1 in AP-site repair","volume":"10","author":"Prasad","year":"2015","journal-title":"PLoS One"},{"key":"2026020905314940300_B25","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1093\/nar\/gki266","article-title":"Human base excision repair enzymes apurinic\/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity","volume":"33","author":"Sukhanova","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B26","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.tibs.2016.10.001","article-title":"Regulation of DNA alkylation damage repair: lessons and therapeutic opportunities","volume":"42","author":"Soll","year":"2017","journal-title":"Trends Biochem Sci"},{"key":"2026020905314940300_B27","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1089\/ars.2010.3466","article-title":"Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage","volume":"14","author":"Svilar","year":"2011","journal-title":"Antioxid Redox Signaling"},{"key":"2026020905314940300_B28","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.1093\/nar\/gkg761","article-title":"A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage","volume":"31","author":"El-Khamisy","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B29","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1093\/nar\/gkt025","article-title":"Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair","volume":"41","author":"Campalans","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B30","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.3390\/cancers14153572","article-title":"Overcoming temozolomide resistance in glioblastoma via enhanced NAD+ bioavailability and inhibition of poly-ADP-ribose glycohydrolase","volume":"14","author":"Li","year":"2022","journal-title":"Cancers"},{"key":"2026020905314940300_B31","doi-asserted-by":"publisher","first-page":"zcab044","DOI":"10.1093\/narcan\/zcab044","article-title":"NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells","volume":"3","author":"Li","year":"2021","journal-title":"NAR Cancer"},{"key":"2026020905314940300_B32","doi-asserted-by":"publisher","first-page":"3775","DOI":"10.1074\/jbc.M114.624718","article-title":"A quantitative assay reveals ligand specificity of the DNA scaffold repair protein XRCC1 and efficient disassembly of complexes of XRCC1 and the poly(ADP-ribose) polymerase 1 by poly(ADP-ribose) glycohydrolase","volume":"290","author":"Kim","year":"2015","journal-title":"J Biol Chem"},{"key":"2026020905314940300_B33","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"2026020905314940300_B34","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41580-020-0257-5","article-title":"The plasticity of DNA replication forks in response to clinically relevant genotoxic stress","volume":"21","author":"Berti","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026020905314940300_B35","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrc3916","article-title":"Replication stress and cancer","volume":"15","author":"Gaillard","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"2026020905314940300_B36","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.gde.2013.04.009","article-title":"The balancing act of DNA repeat expansions","volume":"23","author":"Kim","year":"2013","journal-title":"Curr Opin Genet Dev"},{"key":"2026020905314940300_B37","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/nature12149","article-title":"Pif1 family helicases suppress genome instability at G-quadruplex motifs","volume":"497","author":"Paeschke","year":"2013","journal-title":"Nature"},{"key":"2026020905314940300_B38","doi-asserted-by":"publisher","first-page":"e20190138","DOI":"10.1590\/1678-4685-gmb-2019-0138","article-title":"DNA replication stress: oncogenes in the spotlight","volume":"43","author":"Primo","year":"2019","journal-title":"Genet Mol Biol"},{"key":"2026020905314940300_B39","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/emboj.2011.470","article-title":"dNTP pools determine fork progression and origin usage under replication stress","volume":"31","author":"Poli","year":"2012","journal-title":"EMBO J"},{"key":"2026020905314940300_B40","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.molcel.2011.10.013","article-title":"Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes","volume":"44","author":"Helmrich","year":"2011","journal-title":"Mol Cell"},{"key":"2026020905314940300_B41","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.1038\/s41467-020-17858-2","article-title":"Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites","volume":"11","author":"Promonet","year":"2020","journal-title":"Nat Commun"},{"key":"2026020905314940300_B42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1093\/jmcb\/mjq048","article-title":"Okazaki fragment maturation: nucleases take centre stage","volume":"3","author":"Zheng","year":"2011","journal-title":"J Mol Cell Biol"},{"key":"2026020905314940300_B43","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1158\/0008-5472.CAN-20-1602","article-title":"Replication gaps underlie BRCA deficiency and therapy response","volume":"81","author":"Panzarino","year":"2021","journal-title":"Cancer Res"},{"key":"2026020905314940300_B44","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1016\/j.molcel.2021.07.015","article-title":"Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency","volume":"81","author":"Cong","year":"2021","journal-title":"Mol Cell"},{"key":"2026020905314940300_B45","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/med.22069","article-title":"The recent advance and prospect of poly(ADP-ribose) polymerase inhibitors for the treatment of cancer","volume":"45","author":"Bai","year":"2025","journal-title":"Med Res Rev"},{"key":"2026020905314940300_B46","doi-asserted-by":"publisher","first-page":"e2413954121","DOI":"10.1073\/pnas.2413954121","article-title":"PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer","volume":"121","author":"Ravindranathan","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020905314940300_B47","doi-asserted-by":"publisher","first-page":"114464","DOI":"10.1016\/j.celrep.2024.114464","article-title":"FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition","volume":"43","author":"Liu","year":"2024","journal-title":"Cell Rep"},{"key":"2026020905314940300_B48","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.3390\/cells11121889","article-title":"The influence of PARP, ATR, CHK1 inhibitors on premature mitotic entry and genomic instability in high-grade serous BRCA(MUT) and BRCA(WT) ovarian cancer cells","volume":"11","author":"Gralewska","year":"2022","journal-title":"Cells"},{"key":"2026020905314940300_B49","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.molcel.2020.12.006","article-title":"Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD","volume":"81","author":"Hewitt","year":"2021","journal-title":"Mol Cell"},{"key":"2026020905314940300_B50","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1101\/gad.334516.119","article-title":"PARP and PARG inhibitors in cancer treatment","volume":"34","author":"Slade","year":"2020","journal-title":"Genes Dev"},{"key":"2026020905314940300_B51","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/s41467-018-03159-2","article-title":"PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation","volume":"9","author":"Ronson","year":"2018","journal-title":"Nat Commun"},{"key":"2026020905314940300_B52","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.dnarep.2018.08.021","article-title":"Mechanisms of PARP inhibitor sensitivity and resistance","volume":"71","author":"D\u2019Andrea","year":"2018","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B53","doi-asserted-by":"publisher","first-page":"5060","DOI":"10.1158\/0008-5472.CAN-18-0569","article-title":"Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells","volume":"78","author":"Carruthers","year":"2018","journal-title":"Cancer Res"},{"key":"2026020905314940300_B54","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1128\/MCB.01077-14","article-title":"Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase","volume":"35","author":"Ray\u00a0Chaudhuri","year":"2015","journal-title":"Mol Cell Biol"},{"key":"2026020905314940300_B55","doi-asserted-by":"publisher","first-page":"7776","DOI":"10.1093\/nar\/gku505","article-title":"PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress","volume":"42","author":"Illuzzi","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B56","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1038\/ncomms3993","article-title":"Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation","volume":"4","author":"Min","year":"2013","journal-title":"Nat Commun"},{"key":"2026020905314940300_B57","doi-asserted-by":"publisher","first-page":"eadu0437","DOI":"10.1126\/sciadv.adu0437","article-title":"Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe","volume":"11","author":"Ortega","year":"2025","journal-title":"Sci Adv"},{"key":"2026020905314940300_B58","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1093\/nar\/gkad066","article-title":"PARP1 associates with R-loops to promote their resolution and genome stability","volume":"51","author":"Laspata","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B59","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.tig.2024.04.013","article-title":"(Single-stranded DNA) gaps in understanding BRCAness","volume":"40","author":"Schreuder","year":"2024","journal-title":"Trends Genet"},{"key":"2026020905314940300_B60","doi-asserted-by":"publisher","first-page":"4026","DOI":"10.1016\/j.molcel.2021.09.013","article-title":"Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells","volume":"81","author":"Tirman","year":"2021","journal-title":"Mol Cell"},{"key":"2026020905314940300_B61","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/s41594-024-01279-6","article-title":"Deregulated DNA ADP-ribosylation impairs telomere replication","volume":"31","author":"Wondisford","year":"2024","journal-title":"Nat Struct Mol Biol"},{"key":"2026020905314940300_B62","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/s41467-024-55638-4","article-title":"OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts","volume":"16","author":"De\u00a0Rosa","year":"2025","journal-title":"Nature communications"},{"key":"2026020905314940300_B63","doi-asserted-by":"publisher","first-page":"6280","DOI":"10.1038\/onc.2010.344","article-title":"PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy","volume":"29","author":"Salvati","year":"2010","journal-title":"Oncogene"},{"key":"2026020905314940300_B64","doi-asserted-by":"publisher","article-title":"Single-molecule analysis of PARP1-G-quadruplex interaction","author":"Gaur","DOI":"10.1101\/2025.01.06.631587"},{"key":"2026020905314940300_B65","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/nar\/gkaa1172","article-title":"G-quadruplex loops regulate PARP-1 enzymatic activation","volume":"49","author":"Edwards","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B66","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41586-018-0291-z","article-title":"CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions","volume":"559","author":"Zimmermann","year":"2018","journal-title":"Nature"},{"key":"2026020905314940300_B67","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.molcel.2018.06.004","article-title":"The importance of poly(ADP-Ribose) polymerase as a sensor of unligated Okazaki fragments during DNA replication","volume":"71","author":"Hanzlikova","year":"2018","journal-title":"Mol Cell"},{"key":"2026020905314940300_B68","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/nature03443","article-title":"Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase","volume":"434","author":"Bryant","year":"2005","journal-title":"Nature"},{"key":"2026020905314940300_B69","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature03445","article-title":"Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy","volume":"434","author":"Farmer","year":"2005","journal-title":"Nature"},{"key":"2026020905314940300_B70","doi-asserted-by":"publisher","first-page":"5045","DOI":"10.1093\/nar\/gkr099","article-title":"PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms","volume":"39","author":"Mortusewicz","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B71","doi-asserted-by":"publisher","first-page":"9741","DOI":"10.1093\/nar\/gkx604","article-title":"A novel non-canonical PIP-box mediates PARG interaction with PCNA","volume":"45","author":"Kaufmann","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B72","doi-asserted-by":"publisher","first-page":"5654","DOI":"10.1038\/s41467-019-13508-4","article-title":"Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death","volume":"10","author":"Houl","year":"2019","journal-title":"Nat Commun"},{"key":"2026020905314940300_B73","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.pbiomolbio.2021.01.004","article-title":"DNA replication stress and emerging prospects for PARG inhibitors in ovarian cancer therapy","volume":"163","author":"Pillay","year":"2021","journal-title":"Prog Biophys Mol Biol"},{"key":"2026020905314940300_B74","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.ccell.2019.02.004","article-title":"DNA replication vulnerabilities render ovarian cancer cells sensitive to poly(ADP-Ribose) glycohydrolase inhibitors","volume":"35","author":"Pillay","year":"2019","journal-title":"Cancer Cell"},{"key":"2026020905314940300_B75","doi-asserted-by":"publisher","first-page":"103853","DOI":"10.1016\/j.dnarep.2025.103853","article-title":"DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint","volume":"150","author":"Khan","year":"2025","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B76","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/s13046-021-02124-0","article-title":"Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models","volume":"40","author":"Coulson-Gilmer","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"2026020905314940300_B77","doi-asserted-by":"publisher","first-page":"103700","DOI":"10.1016\/j.dnarep.2024.103700","article-title":"Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity","volume":"140","author":"Saville","year":"2024","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B78","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/s41420-024-02040-0","article-title":"CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer","volume":"10","author":"Acharya","year":"2024","journal-title":"Cell Death Discov"},{"key":"2026020905314940300_B79","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/s12276-021-00613-y","article-title":"Protein arginine methyltransferases: promising targets for cancer therapy","volume":"53","author":"Hwang","year":"2021","journal-title":"Exp Mol Med"},{"key":"2026020905314940300_B80","doi-asserted-by":"publisher","article-title":"Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment","author":"Zhang","DOI":"10.1101\/2024.05.21.595159"},{"key":"2026020905314940300_B81","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1186\/s12885-023-11260-z","article-title":"Inhibiting PRMT5 induces DNA damage and increases anti-proliferative activity of Niraparib, a PARP inhibitor, in models of breast and ovarian cancer","volume":"23","author":"O\u2019Brien","year":"2023","journal-title":"BMC Cancer"},{"key":"2026020905314940300_B82","doi-asserted-by":"publisher","first-page":"101326","DOI":"10.1016\/j.xcrm.2023.101326","article-title":"PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition","volume":"4","author":"Li","year":"2023","journal-title":"Cell Reports Medicine"},{"key":"2026020905314940300_B83","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.molmet.2019.09.013","article-title":"A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor","volume":"30","author":"Giroud-Gerbetant","year":"2019","journal-title":"Molecular Metabolism"},{"key":"2026020905314940300_B84","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/neuonc\/nor011","article-title":"N-methylpurine DNA glycosylase and DNA polymerase \u03b2 modulate BER inhibitor potentiation of glioma cells to temozolomide","volume":"13","author":"Tang","year":"2011","journal-title":"Neuro Oncol"},{"key":"2026020905314940300_B85","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1101\/gad.256214.114","article-title":"Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4","volume":"29","author":"Guillemette","year":"2015","journal-title":"Genes Dev"},{"key":"2026020905314940300_B86","doi-asserted-by":"publisher","first-page":"6381","DOI":"10.1158\/0008-5472.CAN-09-1178","article-title":"Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma","volume":"69","author":"Sakai","year":"2009","journal-title":"Cancer Res"},{"key":"2026020905314940300_B87","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1126\/science.279.5349.349","article-title":"Extension of life-span by introduction of telomerase into normal human cells","volume":"279","author":"Bodnar","year":"1998","journal-title":"Science"},{"key":"2026020905314940300_B88","doi-asserted-by":"publisher","first-page":"9537","DOI":"10.1093\/nar\/gky764","article-title":"Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage","volume":"46","author":"Slyskova","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B89","doi-asserted-by":"publisher","first-page":"5513","DOI":"10.1038\/ncomms6513","article-title":"HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase beta","volume":"5","author":"Fang","year":"2014","journal-title":"Nat Commun"},{"key":"2026020905314940300_B90","doi-asserted-by":"publisher","first-page":"e1610","DOI":"10.3791\/1610","article-title":"Microvolume protein concentration determination using the NanoDrop 2000c spectrophotometer","author":"Desjardins","year":"2009","journal-title":"J Vis Exp"},{"key":"2026020905314940300_B91","doi-asserted-by":"publisher","first-page":"e2994","DOI":"10.21769\/BioProtoc.2994","article-title":"Cell synchronization by double thymidine block","volume":"8","author":"Chen","year":"2018","journal-title":"Bio Protoc"},{"key":"2026020905314940300_B92","doi-asserted-by":"publisher","first-page":"e28203","DOI":"10.1371\/journal.pone.0028203","article-title":"Serum starvation induced cell cycle synchronization facilitates human somatic cells reprogramming","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"2026020905314940300_B93","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1158\/1078-0432.CCR-14-0816","article-title":"Molecular pathways: targeting the cyclin D-CDK4\/6 axis for cancer treatment","volume":"21","author":"VanArsdale","year":"2015","journal-title":"Clin Cancer Res"},{"key":"2026020905314940300_B94","doi-asserted-by":"publisher","first-page":"gkaf574","DOI":"10.1093\/nar\/gkaf574","article-title":"TRIP12\u2019s role in the governance of DNA polymerase beta involvement in DNA damage response and repair","volume":"53","author":"Inanc","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B95","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1177\/2472555217731076","article-title":"Real-time apoptosis and viability high-throughput screening of 3D multicellular tumor spheroids using the Celigo image cytometer","volume":"23","author":"Kessel","year":"2018","journal-title":"SLAS Discovery"},{"key":"2026020905314940300_B96","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1038\/s41596-020-0399-0","article-title":"Proximity labeling in mammalian cells with TurboID and split-TurboID","volume":"15","author":"Cho","year":"2020","journal-title":"Nat Protoc"},{"key":"2026020905314940300_B97","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/19466315.2018.1437071","article-title":"Evaluation of drug combination effect using a Bliss independence dose-response surface model","volume":"10","author":"Liu","year":"2018","journal-title":"Stat Biopharm Res"},{"key":"2026020905314940300_B98","doi-asserted-by":"publisher","first-page":"4849","DOI":"10.1038\/s41598-021-84351-1","article-title":"The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context","volume":"11","author":"Kutuzov","year":"2021","journal-title":"Sci Rep"},{"key":"2026020905314940300_B99","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/s41388-021-02162-0","article-title":"An mRNA expression-based signature for oncogene-induced replication-stress","volume":"41","author":"Guerrero\u00a0Llobet","year":"2022","journal-title":"Oncogene"},{"key":"2026020905314940300_B100","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41573-022-00558-5","article-title":"Targeting replication stress in cancer therapy","volume":"22","author":"da\u00a0Costa","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"2026020905314940300_B101","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/(SICI)1097-0215(19981218)79:6&lt;640::AID-IJC15&gt;3.0.CO;2-Z","article-title":"Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses","volume":"79","author":"Weller","year":"1998","journal-title":"Int J Cancer"},{"key":"2026020905314940300_B102","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1073\/pnas.92.9.3963","article-title":"A simple p53 functional assay for screening cell lines, blood, and tumors","volume":"92","author":"Flaman","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020905314940300_B103","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1750-3639.1999.tb00536.x","article-title":"Frequent co-alterations of TP53, p16\/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines","volume":"9","author":"Ishii","year":"1999","journal-title":"Brain Pathol"},{"key":"2026020905314940300_B104","doi-asserted-by":"publisher","first-page":"8233","DOI":"10.1038\/sj.onc.1207198","article-title":"CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death","volume":"22","author":"Wischhusen","year":"2003","journal-title":"Oncogene"},{"key":"2026020905314940300_B105","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nature03485","article-title":"Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions","volume":"434","author":"Gorgoulis","year":"2005","journal-title":"Nature"},{"key":"2026020905314940300_B106","doi-asserted-by":"publisher","first-page":"113225","DOI":"10.1016\/j.yexcr.2022.113225","article-title":"p53-driven replication stress in nucleoli of malignant epithelial ovarian cancer","volume":"417","author":"Guo","year":"2022","journal-title":"Exp Cell Res"},{"key":"2026020905314940300_B107","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1038\/emboj.2009.206","article-title":"PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination","volume":"28","author":"Bryant","year":"2009","journal-title":"EMBO J"},{"key":"2026020905314940300_B108","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1038\/s41467-018-05588-5","article-title":"PARP2 mediates branched poly ADP-ribosylation in response to DNA damage","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"key":"2026020905314940300_B109","doi-asserted-by":"publisher","first-page":"12143","DOI":"10.1073\/pnas.1919528117","article-title":"Split-TurboID enables contact-dependent proximity labeling in cells","volume":"117","author":"Cho","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020905314940300_B110","doi-asserted-by":"publisher","first-page":"3018","DOI":"10.1016\/j.molcel.2021.05.009","article-title":"XRCC1 prevents toxic PARP1 trapping during DNA base excision repair","volume":"81","author":"Demin","year":"2021","journal-title":"Mol Cell"},{"key":"2026020905314940300_B111","doi-asserted-by":"publisher","first-page":"e113190","DOI":"10.15252\/embj.2022113190","article-title":"Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity","volume":"42","author":"Serrano-Benitez","year":"2023","journal-title":"EMBO J"},{"key":"2026020905314940300_B112","doi-asserted-by":"publisher","first-page":"zcac042","DOI":"10.1093\/narcan\/zcac042","article-title":"Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment","volume":"4","author":"Jackson","year":"2022","journal-title":"NAR Cancer"},{"key":"2026020905314940300_B113","doi-asserted-by":"publisher","first-page":"5588","DOI":"10.1158\/0008-5472.CAN-12-2753","article-title":"Trapping of PARP1 and PARP2 by clinical PARP inhibitors","volume":"72","author":"Murai","year":"2012","journal-title":"Cancer Res"},{"key":"2026020905314940300_B114","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1158\/1535-7163.MCT-13-0803","article-title":"Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib","volume":"13","author":"Murai","year":"2014","journal-title":"Mol Cancer Ther"},{"key":"2026020905314940300_B115","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/s41416-020-1016-2","article-title":"Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models","volume":"123","author":"Dunlop","year":"2020","journal-title":"Br J Cancer"},{"key":"2026020905314940300_B116","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1158\/2767-9764.CRC-23-0070","article-title":"PRMT5 inhibitors regulate DNA damage repair pathways in cancer cells and improve response to PARP inhibition and chemotherapies","volume":"3","author":"Carter","year":"2023","journal-title":"Cancer Res Commun"},{"key":"2026020905314940300_B117","first-page":"10.17912\/micropub.biology.001631","article-title":"Regulation of DNA repair gene expression by PRMT5","volume":"2025","author":"Bliss","year":"2025","journal-title":"MicroPubl Biol"},{"key":"2026020905314940300_B118","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-5936706\/v1","article-title":"PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide","author":"Onishi","year":"2025","journal-title":"Research Square"},{"key":"2026020905314940300_B119","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/s41388-024-03264-1","article-title":"PRMT5-regulated splicing of DNA repair genes drives chemoresistance in breast cancer stem cells","volume":"44","author":"Gillespie","year":"2025","journal-title":"Oncogene"},{"key":"2026020905314940300_B120","doi-asserted-by":"publisher","article-title":"Deoxyuridine-rich cytoplasmic DNA antagonizes STING-dependent innate immune responses and sensitizes resistant tumors to anti-PD-L1 therapy","author":"Pandya","DOI":"10.1101\/2024.04.04.588079"},{"key":"2026020905314940300_B121","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1016\/j.molcel.2024.04.004","article-title":"Unprocessed genomic uracil as a source of DNA replication stress in cancer cells","volume":"84","author":"Saxena","year":"2024","journal-title":"Mol Cell"},{"key":"2026020905314940300_B122","volume-title":"Cell death signaling in cancer biology and treatment. X.-M. Yin and Z. Dong (Series eds.), Cell Death in Biology and Diseases","author":"Vens","year":"2013"},{"key":"2026020905314940300_B123","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"2026020905314940300_B124","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1093\/nar\/26.11.2644","article-title":"DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines","volume":"26","author":"Trucco","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B125","doi-asserted-by":"publisher","first-page":"17860","DOI":"10.1074\/jbc.274.25.17860","article-title":"PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase","volume":"274","author":"Ame","year":"1999","journal-title":"J Biol Chem"},{"key":"2026020905314940300_B126","doi-asserted-by":"publisher","first-page":"103690","DOI":"10.1016\/j.dnarep.2024.103690","article-title":"The dynamics and regulation of PARP1 and PARP2 in response to DNA damage and during replication","volume":"140","author":"Zhang","year":"2024","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B127","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1128\/MMBR.00040-05","article-title":"Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?","volume":"70","author":"Hassa","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026020905314940300_B128","doi-asserted-by":"publisher","article-title":"Uracil-DNA glycosylase deficiency is associated with repressed tumor cell-intrinsic inflammatory signaling and altered sensitivity to exogenous interferons","author":"Vendetti","DOI":"10.1101\/2025.07.28.666960"},{"key":"2026020905314940300_B129","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.molcel.2025.01.031","article-title":"Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1\/2-deficient tumors","volume":"85","author":"Musiani","year":"2025","journal-title":"Mol Cell"},{"key":"2026020905314940300_B130","doi-asserted-by":"publisher","first-page":"11600","DOI":"10.1093\/nar\/gkac948","article-title":"PARP1 proximity proteomics reveals interaction partners at stressed replication forks","volume":"50","author":"Mosler","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B131","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41586-024-07217-2","article-title":"Transcription-replication conflicts underlie sensitivity to PARP inhibitors","volume":"628","author":"Petropoulos","year":"2024","journal-title":"Nature"},{"key":"2026020905314940300_B132","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1021\/bi9731089","article-title":"Regulation of the expression or recruitment of components of the DNA synthesome by poly(ADP-ribose) polymerase","volume":"37","author":"Simbulan-Rosenthal","year":"1998","journal-title":"Biochemistry"},{"key":"2026020905314940300_B133","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1023\/A:1006988832729","article-title":"Involvement of PARP and poly(ADP-ribosyl)ation in the early stages of apoptosis and DNA replication","volume":"193","author":"Simbulan-Rosenthal","year":"1999","journal-title":"Mol Cell Biochem"},{"key":"2026020905314940300_B134","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1093\/nar\/26.8.1891","article-title":"Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication","volume":"26","author":"Dantzer","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B135","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nsmb.2501","article-title":"Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition","volume":"20","author":"Berti","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"2026020905314940300_B136","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.molcel.2015.07.031","article-title":"Timeless interacts with PARP-1 to promote homologous recombination repair","volume":"60","author":"Xie","year":"2015","journal-title":"Mol Cell"},{"key":"2026020905314940300_B137","doi-asserted-by":"publisher","first-page":"23028","DOI":"10.1074\/jbc.M202390200","article-title":"Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1","volume":"277","author":"Schreiber","year":"2002","journal-title":"J Biol Chem"},{"key":"2026020905314940300_B138","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.3390\/cancers14153676","article-title":"Live cell detection of poly(ADP-Ribose) for use in genetic and genotoxic compound screens","volume":"14","author":"Koczor","year":"2022","journal-title":"Cancers"},{"key":"2026020905314940300_B139","doi-asserted-by":"publisher","first-page":"103843","DOI":"10.1016\/j.dnarep.2025.103843","article-title":"Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases","volume":"149","author":"Call","year":"2025","journal-title":"DNA Repair (Amst)"},{"key":"2026020905314940300_B140","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/10409230390259382","article-title":"The protein components and mechanism of eukaryotic Okazaki fragment maturation","volume":"38","author":"Kao","year":"2003","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"2026020905314940300_B141","doi-asserted-by":"publisher","first-page":"5003","DOI":"10.1093\/nar\/gkab269","article-title":"HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation","volume":"49","author":"Kumamoto","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026020905314940300_B142","doi-asserted-by":"publisher","first-page":"5389","DOI":"10.1158\/0008-5472.CAN-09-4716","article-title":"Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells","volume":"70","author":"Gottipati","year":"2010","journal-title":"Cancer Res"},{"key":"2026020905314940300_B143","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-0716-2891-1_3","article-title":"Quantitative analysis of nuclear poly(ADP-Ribose) dynamics in response to laser-induced DNA damage","volume":"2609","author":"Koczor","year":"2023","journal-title":"Methods Mol Biol"},{"key":"2026020905314940300_B144","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1126\/science.abb4542","article-title":"Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors","volume":"372","author":"Fugger","year":"2021","journal-title":"Science"},{"key":"2026020905314940300_B145","doi-asserted-by":"publisher","first-page":"4692","DOI":"10.1016\/j.molcel.2021.09.005","article-title":"Loss of nuclear DNA ligase III reverts PARP inhibitor resistance in BRCA1\/53BP1 double-deficient cells by exposing ssDNA gaps","volume":"81","author":"Paes\u00a0Dias","year":"2021","journal-title":"Mol Cell"},{"key":"2026020905314940300_B146","doi-asserted-by":"publisher","first-page":"zcaf015","DOI":"10.1093\/narcan\/zcaf015","article-title":"PARP inhibitor response is enhanced in prostate cancer when XRCC1 expression is reduced","volume":"7","author":"Goel","year":"2025","journal-title":"NAR Cancer"},{"key":"2026020905314940300_B147","doi-asserted-by":"publisher","article-title":"Mapping the genetic interaction network of PARP inhibitor response","author":"Simpson","DOI":"10.1101\/2023.08.19.553986"},{"key":"2026020905314940300_B148","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1158\/1535-7163.MCT-24-0822","article-title":"CRISPR screens identify POLB as a synthetic lethal enhancer of PARP inhibition exclusively in BRCA-mutated tumors","volume":"24","author":"Lazarides","year":"2025","journal-title":"Mol Cancer Ther"},{"key":"2026020905314940300_B149","doi-asserted-by":"publisher","first-page":"17699","DOI":"10.1073\/pnas.0406182101","article-title":"Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality","volume":"101","author":"Koh","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026020905314940300_B150","doi-asserted-by":"publisher","first-page":"RP89303","DOI":"10.7554\/eLife.89303","article-title":"DePARylation is critical for S phase progression and cell survival","volume":"12","author":"Nie","year":"2024","journal-title":"eLife"},{"key":"2026020905314940300_B151","doi-asserted-by":"publisher","first-page":"2948","DOI":"10.1016\/j.ejca.2005.08.027","article-title":"Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide","volume":"41","author":"Tentori","year":"2005","journal-title":"Eur J Cancer"},{"key":"2026020905314940300_B152","doi-asserted-by":"publisher","first-page":"990","DOI":"10.4161\/cc.11.5.19482","article-title":"Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells","volume":"11","author":"Fathers","year":"2012","journal-title":"Cell Cycle"},{"key":"2026020905314940300_B153","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/s44318-024-00043-2","article-title":"PARG-deficient tumor cells have an increased dependence on EXO1\/FEN1-mediated DNA repair","volume":"43","author":"Andronikou","year":"2024","journal-title":"EMBO J"},{"key":"2026020905314940300_B154","doi-asserted-by":"publisher","first-page":"111371","DOI":"10.1016\/j.celrep.2022.111371","article-title":"Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-\u03b1\/\u03b2 expression","volume":"40","author":"Sugitani","year":"2022","journal-title":"Cell Rep"},{"key":"2026020905314940300_B155","doi-asserted-by":"publisher","first-page":"834636","DOI":"10.3389\/fcimb.2022.834636","article-title":"KAP1\/TRIM28: transcriptional activator and\/or repressor of viral and cellular programs?","volume":"12","author":"Randolph","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2026020905314940300_B156","doi-asserted-by":"publisher","first-page":"R78","DOI":"10.1186\/gb-2011-12-8-r78","article-title":"A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1","volume":"12","author":"Blasius","year":"2011","journal-title":"Genome Biol"},{"key":"2026020905314940300_B157","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/ncb1446","article-title":"Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway","volume":"8","author":"Ziv","year":"2006","journal-title":"Nat Cell Biol"},{"key":"2026020905314940300_B158","doi-asserted-by":"publisher","first-page":"8109","DOI":"10.1158\/0008-5472.CAN-06-0140","article-title":"Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition","volume":"66","author":"McCabe","year":"2006","journal-title":"Cancer Res"},{"key":"2026020905314940300_B159","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1124\/mol.110.067199","article-title":"Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells","volume":"78","author":"Mitchell","year":"2010","journal-title":"Mol Pharmacol"}],"container-title":["NAR Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/narcancer\/article-pdf\/7\/4\/zcaf057\/66173890\/zcaf057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/narcancer\/article-pdf\/7\/4\/zcaf057\/66173890\/zcaf057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:31:59Z","timestamp":1770633119000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/narcancer\/article\/doi\/10.1093\/narcan\/zcaf057\/8407657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,7]]},"references-count":159,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,7]]}},"URL":"https:\/\/doi.org\/10.1093\/narcan\/zcaf057","relation":{},"ISSN":["2632-8674"],"issn-type":[{"value":"2632-8674","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,10,7]]},"article-number":"zcaf057"}}