{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T04:34:07Z","timestamp":1784090047520,"version":"3.55.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830027"],"award-info":[{"award-number":["81830027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61871294"],"award-info":[{"award-number":["61871294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LR19C060001"],"award-info":[{"award-number":["LR19C060001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eye diseases are remarkably common and encompass a large and diverse range of morbidities that affect different components of the visual system and visual function. With advances in omics technology of eye disorders, genome-scale datasets have been rapidly accumulated in genetics and epigenetics field. However, the efficient collection and comprehensive analysis of different kinds of omics data are lacking. Herein, we developed EyeDiseases (https:\/\/eyediseases.bio-data.cn\/), the first database for multi-omics data integration and interpretation of human eyes diseases. It contains 1344 disease-associated genes with genetic variation, 1774 transcription files of bulk cell expression and single-cell RNA-seq, 105 epigenomics data across 185 kinds of human eye diseases. Using EyeDiseases, we investigated SARS-CoV-2 potential tropism in eye infection and found that the SARS-CoV-2 entry factors, ACE2 and TMPRSS2 are highly correlated with cornea and keratoconus, suggest that ocular surface cells are susceptible to infection by SARS-CoV-2. Additionally, integrating analysis of Age-related macular degeneration (AMD) GWAS loci and co-expression data revealed 9 associated genes involved in HIF-1 signaling pathway and voltage-gate potassium channel complex. The EyeDiseases provides a valuable resource for accelerating the discovery and validation of candidate loci and genes contributed to the molecular diagnosis and therapeutic vulnerabilities with various eyes diseases.<\/jats:p>","DOI":"10.1093\/nargab\/lqab050","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T19:13:59Z","timestamp":1622574839000},"source":"Crossref","is-referenced-by-count":22,"title":["EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1896-2561","authenticated-orcid":false,"given":"Jian","family":"Yuan","sequence":"first","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbo","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-6042","authenticated-orcid":false,"given":"Jianzhong","family":"Su","sequence":"additional","affiliation":[{"name":"School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou\u00a0325027, China"},{"name":"National Clinical Research Center for Ocular Disease, Wenzhou\u00a0325027, China"},{"name":"Institute of Biomedical Big Data, Wenzhou Medical University, Wenzhou\u00a0325027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"2021070810412567200_B1","author":"W.H.O.","year":"2019"},{"key":"2021070810412567200_B2","first-page":"1","volume-title":"Global Data on Visual Impairments 2010","author":"W.H.O.","year":"2012"},{"key":"2021070810412567200_B3","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.ophtha.2018.04.013","article-title":"Global prevalence of presbyopia and vision impairment from uncorrected presbyopia: systematic review, meta-analysis, and modelling","volume":"125","author":"Fricke","year":"2018","journal-title":"Ophthalmology"},{"key":"2021070810412567200_B4","doi-asserted-by":"crossref","first-page":"e888","DOI":"10.1016\/S2214-109X(17)30293-0","article-title":"Magnitude, temporal trends, and projections of the global prevalence of 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