{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:01:55Z","timestamp":1790989315711,"version":"4.1.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["1032-00370B"],"award-info":[{"award-number":["1032-00370B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CO$_2$ concentrations above air level (0.04%) are beneficial for the growth of cyanobacteria. However, very high CO$_2$ levels inhibit growth, limiting the usability of cyanobacteria for carbon capture and biotechnological applications. The transcriptomic changes in the cyanobacterium Synechococcus\u00a0sp.\u00a0PCC\u00a07002 were investigated at varying growth rates governed by different gas-phase CO$_2$ concentrations, ranging from limiting (0.04%) to optimal (4% and 8%) to inhibitory high (30%). Compared to optimal CO$_2$ concentrations, large differences in the transcriptome were observed in limiting and inhibiting CO$_2$. At 30% CO$_2$, genes encoding CO$_2$ uptake mechanisms, photosynthetic electron transfer, and light-harvesting antennae proteins were down-regulated compared to lower CO$_2$. Genes involved in the ribosomal machinery and biosynthetic pathways were down-regulated at 30% and 0.04% CO$_2$, consistent with the observed reduced growth. The genes most strongly up-regulated at 30% CO$_2$ were primarily associated with stress responses, but did not closely resemble the transcriptomic changes at other stress conditions previously described. The small RNA PsrR1 was strongly up-regulated at 30% CO$_2$ and is likely to be involved in the regulation of growth. These transcriptomic insights are essential for the engineering of fast-growing cyanobacteria at high CO$_2$, which can be applied in carbon capture from industrial point sources.<\/jats:p>","DOI":"10.1093\/nargab\/lqaf207","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:55:47Z","timestamp":1764420947000},"source":"Crossref","is-referenced-by-count":2,"title":["Very high CO2 concentrations inhibit photosynthesis and trigger transcriptomic stress responses in cyanobacteria"],"prefix":"10.1093","volume":"8","author":[{"given":"Adrian Sven","family":"Geissler","sequence":"first","affiliation":[{"name":"Center for non-coding RNA in Technology and Health, Department of Veterinary and Animal Sciences, University of Copenhagen , Frederiksberg 1870 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Carrasquer-Alvarez","sequence":"additional","affiliation":[{"name":"Marine Biology Section, Department of Biology, University of Copenhagen , Helsing\u00f8r 3000 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5823-4000","authenticated-orcid":false,"given":"Jan","family":"Gorodkin","sequence":"additional","affiliation":[{"name":"Center for non-coding RNA in Technology and Health, Department of Veterinary and Animal Sciences, University of Copenhagen , Frederiksberg 1870 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-8109","authenticated-orcid":false,"given":"Niels-Ulrik","family":"Frigaard","sequence":"additional","affiliation":[{"name":"Marine Biology Section, Department of Biology, University of Copenhagen , Helsing\u00f8r 3000 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-4927","authenticated-orcid":false,"given":"Stefan Ernst","family":"Seemann","sequence":"additional","affiliation":[{"name":"Center for non-coding RNA in Technology and Health, Department of Veterinary and Animal Sciences, University of Copenhagen , Frederiksberg 1870 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"2026011002570424700_B1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.81800","article-title":"CO2 capture for industries by algae","volume-title":"Algae","author":"Anguselvi","year":"2019"},{"key":"2026011002570424700_B2","doi-asserted-by":"publisher","first-page":"100007","DOI":"10.1016\/j.ccst.2021.100007","article-title":"Minimizing carbon footprint via microalgae as a biological capture","volume":"1","author":"Onyeaka","year":"2021","journal-title":"Carbon Capture Sci Technol"},{"key":"2026011002570424700_B3","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.biotechadv.2018.01.005","article-title":"Tailoring cyanobacterial cell factory for improved industrial properties","volume":"36","author":"Luan","year":"2018","journal-title":"Biotechnol Adv"},{"key":"2026011002570424700_B4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/B978-0-08-101023-5.00013-3","article-title":"13\u2014Synthetic biology of cyanobacteria for production of biofuels and high-value products","volume-title":"Microalgae-Based Biofuels and Bioproducts. 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