{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:34:32Z","timestamp":1791862472307,"version":"4.3.4"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["5715"],"award-info":[{"award-number":["5715"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["01951"],"award-info":[{"award-number":["01951"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genes and proteins show variable expression patterns throughout the human body. However, it is not clear whether relative differences in mRNA concentrations are retained on the protein level. Furthermore, inter-individual protein concentration variability within single tissue types has not been comprehensively explored. Here, we used the Gini index for in-depth concentration variability analysis of publicly available transcriptomics and proteomics data, and of an in-house proteomics dataset of human liver and jejunum from 38 donors. We found that the transfer of concentration variability from mRNA to protein is limited, that established \u2018reference genes\u2019 for data normalization vary markedly at the protein level, that protein concentrations cover a wide variability spectrum within single tissue types, and that concentration variability analysis can be a convenient starting point for identifying disease-associated proteins and novel biomarkers. Our results emphasize the importance of considering individual concentration levels, as opposed to population averages, for personalized systems biology analysis.<\/jats:p>","DOI":"10.1093\/nargab\/lqz010","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T19:30:41Z","timestamp":1572463841000},"source":"Crossref","is-referenced-by-count":79,"title":["Global variability analysis of mRNA and protein concentrations across and within human tissues"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-7518","authenticated-orcid":false,"given":"Christine","family":"Wegler","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Uppsala University, Uppsala SE-75123, Sweden"},{"name":"DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-43183, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-8184","authenticated-orcid":false,"given":"Magnus","family":"\u00d6lander","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Uppsala University, Uppsala SE-75123, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek R","family":"Wi\u015bniewski","sequence":"additional","affiliation":[{"name":"Biochemical Proteomics Group, Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried D-82152, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Lundquist","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Uppsala University, Uppsala SE-75123, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Zettl","sequence":"additional","affiliation":[{"name":"Biochemical Proteomics Group, Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried D-82152, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-1769","authenticated-orcid":false,"given":"Anders","family":"\u00c5sberg","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Oslo, Oslo NO-0316, Norway"},{"name":"Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo NO-0316, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8ran","family":"Hjelmes\u00e6th","sequence":"additional","affiliation":[{"name":"Morbid Obesity Centre, Department of Medicine, Vestfold Hospital Trust, T\u00f8nsberg NO-3103, Norway"},{"name":"Department of Endocrinology, Morbid Obesity and Preventive Medicine, Institute of Clinical Medicine, University of Oslo, Oslo NO-0316, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy B","family":"Andersson","sequence":"additional","affiliation":[{"name":"DMPK, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-43183, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-7395","authenticated-orcid":false,"given":"Per","family":"Artursson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Science for Life Laboratory, Uppsala University, Uppsala SE-75123, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"2020103008522982100_B1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"2020103008522982100_B2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: a revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. 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