{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:18:43Z","timestamp":1793395123982,"version":"4.5.0"},"reference-count":138,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00ES033738"],"award-info":[{"award-number":["R00ES033738"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Merrin Family Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The study of RAD51 regulators in female reproductive diseases has novel biomarker potential and implications for therapeutic advancement. Regulators of RAD51 play important roles in maintaining genome integrity and variations in these genes have been identified in female reproductive diseases including primary ovarian insufficiency (POI), endometriosis, and polycystic ovary syndrome (PCOS). RAD51 modulators change RAD51 activity in homologous recombination, replication stress, and template switching pathways. However, molecular implications of these proteins in primary ovarian insufficiency, endometriosis, and polycystic ovary syndrome have been understudied. For each reproductive disease, we provide its definition, current diagnostic and therapeutic treatment strategies, and associated genetic variations. Variants were discovered in RAD51, and regulators including DMC1, RAD51B, SWS1, SPIDR, XRCC2\u00a0and BRCA2 linked with POI. Endometriosis is associated with variants in XRCC3, BRCA1\u00a0and CSB genes. Variants in BRCA1 were associated with PCOS.\u00a0Our analysis identified\u00a0novel biomarkers for POI (DMC1 and RAD51B) and PCOS (BRCA1). Further biochemical and cellular analyses of RAD51 regulator functions in reproductive disorders will advance our understanding of the pathogenesis of these diseases.<\/jats:p>","DOI":"10.1093\/narmme\/ugae010","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T02:44:46Z","timestamp":1727577886000},"source":"Crossref","is-referenced-by-count":5,"title":["The role of RAD51 regulators and variants in primary ovarian insufficiency, endometriosis,\u00a0and polycystic ovary syndrome"],"prefix":"10.1093","volume":"1","author":[{"given":"Maggie","family":"Witham","sequence":"first","affiliation":[{"name":"Department of Biology, Tufts University , Medford , MA\u00a0 02155 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-8623","authenticated-orcid":false,"given":"Sarah\u00a0R","family":"Hengel","sequence":"additional","affiliation":[{"name":"Department of Biology, Tufts University , Medford , MA\u00a0 02155 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"2025010217123673200_B1","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1038\/s41467-020-17324-z","article-title":"Sequential role of RAD51 paralog complexes in replication fork remodeling and restart","volume":"11","author":"Berti","year":"2020","journal-title":"Nat. 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Reprod."},{"key":"2025010217123673200_B44","doi-asserted-by":"crossref","first-page":"1269009","DOI":"10.3389\/fendo.2023.1269009","article-title":"Reproductive health in Turner's syndrome: from puberty to pregnancy","volume":"14","author":"Porcu","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"2025010217123673200_B45","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/01.AOG.0000451757.51964.98","article-title":"Committee Opinion No. 605. Primary Ovarian Insufficiency in Adolescents and Young Women","volume":"124","author":"Committee on Adolescent Health Care","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"2025010217123673200_B46","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJMcp0808697","article-title":"Clinical practice. Primary ovarian insufficiency","volume":"360","author":"Nelson","year":"2009","journal-title":"N. Engl. J. 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Gynecol."},{"key":"2025010217123673200_B50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/humrep\/del346","article-title":"Serum anti-Mullerian hormone expression in women with premature ovarian failure","volume":"22","author":"Meduri","year":"2007","journal-title":"Hum. Reprod."},{"key":"2025010217123673200_B51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000080598","article-title":"Roles of RecA homologues Rad51 and Dmc1 during meiotic recombination","volume":"107","author":"Shinohara","year":"2004","journal-title":"Cytogenet. Genome Res."},{"key":"2025010217123673200_B52","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/EJE-07-0400","article-title":"Genetic investigation of four meiotic genes in women with premature ovarian failure","volume":"158","author":"Mandon-Pepin","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"2025010217123673200_B53","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1093\/nar\/gkn362","article-title":"Structural and functional analyses of the DMC1-M200V polymorphism found in the human population","volume":"36","author":"Hikiba","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2025010217123673200_B54","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/jmedgenet-2017-104992","article-title":"DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing","volume":"55","author":"He","year":"2018","journal-title":"Journa of Medical Genetics"},{"key":"2025010217123673200_B55","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.rbmo.2012.10.016","article-title":"Mutations in DMC1 are not responsible for premature ovarian failure in Chinese women","volume":"26","author":"Wang","year":"2013","journal-title":"Reprod. Biomed. 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