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Despite their importance, knowledge of these modifiers remains fragmented across different experimental models of neurodegenerative disorders (NDs). To address this lacuna, we developed eVGeMdb (https:\/\/project.iith.ac.in\/cgntlab\/eVGeMdb\/), a manually curated, comprehensive database of experimentally validated genetic modifiers of major NDs, including Amyotrophic Lateral Sclerosis, Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, Spinocerebellar ataxias, Fragile X-associated Tremor\/Ataxia Syndrome, and other general PolyQ disorders. eVGeMdb integrates modifiers from commonly used diverse experimental model systems, including Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae, cellular models (human, mice, Drosophila cells), and mouse. The database currently incorporates over 17000 entries, each annotated with experimental context, gene-specific functional information, relevant human orthologs, and links to protein\u2013protein interaction networks and enriched pathways. The resource enables cross-disease and model-specific comparisons, allowing the identification of both universal and disease-specific modifiers. By consolidating dispersed genetic modifier information into a single, accessible platform, eVGeMdb provides a comprehensive tool for researchers in the field to explore modifier effects, prioritize experimental validations, formulate novel hypotheses, and investigate pathophysiological mechanisms underlying neurodegenerative disorders.<\/jats:p>","DOI":"10.1093\/narmme\/ugaf044","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:33:07Z","timestamp":1768307587000},"source":"Crossref","is-referenced-by-count":0,"title":["eVGeMdb: a manually curated database for experimentally validated genetic modifiers of neurodegenerative disorders"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-5400","authenticated-orcid":false,"given":"Subashani","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Indian Institute of Technology Hyderabad , Kandi, Telangana 502284 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