{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:06:28Z","timestamp":1779692788388,"version":"3.53.1"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale"},{"name":"University Claude Bernard Lyon 1"},{"name":"l'Association Fran\u00e7aise contre les Myopathies (AFM)-t\u00e9l\u00e9thon"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-CE17-0018 IFN-Epi-IM"],"award-info":[{"award-number":["ANR-21-CE17-0018 IFN-Epi-IM"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013465","name":"AFM-t\u00e9l\u00e9thon","doi-asserted-by":"publisher","award":["ANR-10-LABX-61 LabEX DEVweCAN"],"award-info":[{"award-number":["ANR-10-LABX-61 LabEX DEVweCAN"]}],"id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013465","name":"AFM-t\u00e9l\u00e9thon","doi-asserted-by":"publisher","award":["ANR-20-COV9-0004-01"],"award-info":[{"award-number":["ANR-20-COV9-0004-01"]}],"id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dynamique des interactions entre chromatines virale et cellulaire","award":["GDR2194"],"award-info":[{"award-number":["GDR2194"]}]},{"name":"Architecture et Dynamique du Noyau & des G\u00e9nomes"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Skeletal muscle regeneration is driven by muscle stem cells (MuSCs), which proliferate, differentiate, and fuse to reform myofibers and restore muscle function. This myogenesis process is driven both by intrinsic MuSC properties and extrinsic cues. While coordinated inflammatory signals are necessary for healthy regeneration, chronic inflammation participates in various pathologies affecting the skeletal muscle. In the idiopathic inflammatory myopathy dermatomyositis (DM), MuSCs exhibit impaired myogenesis in vitro, indicating that they may have acquired intrinsic defects, contributing to the disease and providing a mechanism for sustained patient muscle weakness despite efficient anti-inflammatory treatments. Here, we investigated the transcriptomic regulation of DM-derived MuSCs, with a focus on the H3.3 histone variant that regulates myogenesis progression. DM-derived MuSCs were unable to effectively execute the myogenic transcriptional program during in vitro differentiation. They exhibited an activated canonical tumor necrosis factor (TNF)-\u237a signaling. They also showed reduced expression of H3.3 and its chaperone genes, coupled with a decrease in H3.3 deposition across the entire genome, and particularly at myogenic regulatory factor loci. The loss of H3.3 combined with elevated TNF-\u237a signaling was associated with a failure of DM-derived MuSCs to achieve myogenesis, suggesting a mechanistic link between epigenetic dysregulation and defective muscle regeneration in humans.<\/jats:p>","DOI":"10.1093\/narmme\/ugag022","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T11:42:41Z","timestamp":1779536561000},"source":"Crossref","is-referenced-by-count":0,"title":["Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway"],"prefix":"10.1093","volume":"3","author":[{"given":"Wilhelm","family":"Bouchereau","sequence":"first","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chenane","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, INSERM U 974, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris, 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Weiss-Gayet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-0227","authenticated-orcid":false,"given":"Lola","family":"Lessard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1148-5368","authenticated-orcid":false,"given":"Yseult","family":"Cardona","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Mounier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Gallay","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3185-7993","authenticated-orcid":false,"given":"Yves","family":"Allenbach","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, INSERM U 974, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris, 75013 ,","place":["France"]},{"name":"Assistance Publique H\u00f4pitaux de Paris, Centre de r\u00e9f\u00e9rence Myopathies Inflammatoires, D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris, 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Benveniste","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Myologie, Sorbonne Universit\u00e9, INSERM U 974, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris, 75013 ,","place":["France"]},{"name":"Assistance Publique H\u00f4pitaux de Paris, Centre de r\u00e9f\u00e9rence Myopathies Inflammatoires, D\u00e9partement de M\u00e9decine Interne et Immunologie Clinique, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re , Paris, 75013 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-5783","authenticated-orcid":false,"given":"Armelle","family":"Corpet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]},{"name":"Institut universitaire de France (IUF) , Paris, 75231 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1262-502X","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Chazaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9248-648X","authenticated-orcid":false,"given":"Patrick","family":"Lomonte","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle , Lyon, 69008 ,","place":["France"]},{"name":"LabEx DEVweCAN, Universit\u00e9 Lyon 1 , Lyon, 69008 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"2026052502563769800_B1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/bs.ctdb.2024.01.012","article-title":"Skeletal muscle niche, at the crossroad of cell\/cell communications","volume":"158","author":"Theret","year":"2024","journal-title":"Curr Top Dev 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