{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:36:58Z","timestamp":1782139018947,"version":"3.54.5"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"DOI":"10.1093\/ndt\/16.11.2146","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:42:52Z","timestamp":1027708972000},"page":"2146-2151","source":"Crossref","is-referenced-by-count":14,"title":["Influence of aldosterone vs endothelin receptor antagonism on renovascular function in liquorice\u2010induced hypertension"],"prefix":"10.1093","volume":"16","author":[{"given":"Thomas","family":"Quaschning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ruschitzka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Niggli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn M. B.","family":"Lunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Christ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wehling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"L\u00fcscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2001,11]]},"reference":[{"key":"key\n\t\t\t\t20180110092332_R1","doi-asserted-by":"crossref","unstructured":"Lifton RP, Dluhy RG, Powers\u2009M et al. A chimaeric 11 beta\u2010hydroxylase\/aldosterone synthase gene causes glucocorticoid\u2010remediable aldosteronism and human hypertension. Nature1992; 355: 262\u2013265","DOI":"10.1038\/355262a0"},{"key":"key\n\t\t\t\t20180110092332_R2","doi-asserted-by":"crossref","unstructured":"Mune T, Rogerson FM, Nikkila H, Agarwal AK, White PC. Human hypertension caused by mutations in the kidney isozyme of 11 beta\u2010hydroxysteroid dehydrogenase. Nature Genet1995; 10: 394\u2013399","DOI":"10.1038\/ng0895-394"},{"key":"key\n\t\t\t\t20180110092332_R3","doi-asserted-by":"crossref","unstructured":"Kelly JJ, Mangos G, Williamson PM, Whitworth JA. Cortisol and hypertension. Clin Exp Pharmacol Physiol1998; 25 [Suppl]: S51\u201356","DOI":"10.1111\/j.1440-1681.1998.tb02301.x"},{"key":"key\n\t\t\t\t20180110092332_R4","doi-asserted-by":"crossref","unstructured":"Ploeger BA, Meulenbelt J, DeJongh J. Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling. Toxicol Appl Pharmacol2000; 162: 177\u2013188","DOI":"10.1006\/taap.1999.8843"},{"key":"key\n\t\t\t\t20180110092332_R5","doi-asserted-by":"crossref","unstructured":"Hatakeyama H, Inaba S, Miyamori I. 11beta\u2010hydroxysteroid dehydrogenase in cultured human vascular cells. Possible role in the development of hypertension. Hypertension1999; 33: 1179\u20131184","DOI":"10.1161\/01.HYP.33.5.1179"},{"key":"key\n\t\t\t\t20180110092332_R6","doi-asserted-by":"crossref","unstructured":"Soro A, Ingram MC, Tonolo G, Glorioso N, Fraser R. Evidence of coexisting changes in 11 beta\u2010hydroxysteroid dehydrogenase and 5 beta\u2010reductase activity in subjects with untreated essential hypertension. Hypertension1995; 25: 67\u201370","DOI":"10.1161\/01.HYP.25.1.67"},{"key":"key\n\t\t\t\t20180110092332_R7","doi-asserted-by":"crossref","unstructured":"Noll G, Wenzel RR, Schneider\u2009M et al. Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. Circulation1996; 93: 866\u2013869","DOI":"10.1161\/01.CIR.93.5.866"},{"key":"key\n\t\t\t\t20180110092332_R8","doi-asserted-by":"crossref","unstructured":"Yanagisawa M, Kurihara H, Kimura S, Goto K, Masaki T. A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels. J Hypertens1988; 6 [Suppl]: S188\u2013191","DOI":"10.1097\/00004872-198812040-00056"},{"key":"key\n\t\t\t\t20180110092332_R9","doi-asserted-by":"crossref","unstructured":"Barton M, d'Uscio LV, Shaw S et al. ET(A) receptor blockade prevents increased tissue endothelin\u20101, vascular hypertrophy, and endothelial dysfunction in salt\u2010sensitive hypertension. Hypertension1998; 31: 499\u2013504","DOI":"10.1161\/01.HYP.31.1.499"},{"key":"key\n\t\t\t\t20180110092332_R10","doi-asserted-by":"crossref","unstructured":"Krum H, Viskoper RJ, Lacourciere Y, Budde M, Charlon V. The effect of an endothelin\u2010receptor antagonist, bosentan, on blood pressure in patients with essential hypertension. Bosentan Hypertension Investigators. N Engl J Med1998; 338: 784\u2013790","DOI":"10.1056\/NEJM199803193381202"},{"key":"key\n\t\t\t\t20180110092332_R11","doi-asserted-by":"crossref","unstructured":"Farquharson CA, Struthers AD. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I\/angiotensin II conversion in patients with chronic heart failure. Circulation2000; 101: 594\u2013597","DOI":"10.1161\/01.CIR.101.6.594"},{"key":"key\n\t\t\t\t20180110092332_R12","unstructured":"Struthers AD. Mineralocorticoid receptor blockade in chronic heart failure. J Hum Hypertens1995; 9: 443\u2013446"},{"key":"key\n\t\t\t\t20180110092332_R13","doi-asserted-by":"crossref","unstructured":"Pitt B, Zannad F, Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med1999; 341: 709\u2013717","DOI":"10.1056\/NEJM199909023411001"},{"key":"key\n\t\t\t\t20180110092332_R14","doi-asserted-by":"crossref","unstructured":"Cozza EN, Gomez\u2010Sanchez CE. Mechanisms of ET\u20101 potentiation of angiotensin II stimulation of aldosterone production. Am J Physiol1993; 265: E179\u2013183","DOI":"10.1152\/ajpendo.1993.265.2.E179"},{"key":"key\n\t\t\t\t20180110092332_R15","doi-asserted-by":"crossref","unstructured":"S\u00fctsch G, Bertel O, Rickenbacher P et al. Regulation of aldosterone secretion in patients with chronic congestive heart failure by endothelins. Am J Cardiol2000; 85: 973\u2013976","DOI":"10.1016\/S0002-9149(99)00912-1"},{"key":"key\n\t\t\t\t20180110092332_R16","doi-asserted-by":"crossref","unstructured":"Quaschning T, Ruschitzka F, Shaw S, L\u00fcscher TF. Aldosterone receptor antagonism normalizes vascular function in liquorice\u2010induced hypertension. Hypertension2001; 37: 801\u2013805","DOI":"10.1161\/01.HYP.37.2.801"},{"key":"key\n\t\t\t\t20180110092332_R17","doi-asserted-by":"crossref","unstructured":"Webb RC, Vander AJ, Henry JP. Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice. Hypertension1987; 9: 268\u2013276","DOI":"10.1161\/01.HYP.9.3.268"},{"key":"key\n\t\t\t\t20180110092332_R18","doi-asserted-by":"crossref","unstructured":"L\u00fcscher TF, Diederich D, Siebenmann R et al. Difference between endothelium\u2010dependent relaxation in arterial and in venous coronary bypass grafts. N Engl J Med1988; 319: 462\u2013467","DOI":"10.1056\/NEJM198808253190802"},{"key":"key\n\t\t\t\t20180110092332_R19","doi-asserted-by":"crossref","unstructured":"Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res1980; 47: 1\u20139","DOI":"10.1161\/01.RES.47.1.1"},{"key":"key\n\t\t\t\t20180110092332_R20","doi-asserted-by":"crossref","unstructured":"Ferrari P, Krozowski Z. Role of the 11beta\u2010hydroxysteroid dehydrogenase type 2 in blood pressure regulation. Kidney Int2000; 57: 1374\u20131381","DOI":"10.1046\/j.1523-1755.2000.00978.x"},{"key":"key\n\t\t\t\t20180110092332_R21","doi-asserted-by":"crossref","unstructured":"Duax WL, Ghosh D. Structure and mechanism of action and inhibition of steroid dehydrogenase enzymes involved in hypertension. Endocrine Res1998; 24: 521\u2013529","DOI":"10.3109\/07435809809032641"},{"key":"key\n\t\t\t\t20180110092332_R22","doi-asserted-by":"crossref","unstructured":"Ruschitzka F, Quaschning T, Noll G et al. ETA receptor antagonism prevents vascular dysfunction and hypertension induced by 11\u03b2\u2010hydroxysteroid dehydrogenase inhibition. Role of nitric oxide. Circulation2001; 103: 3129\u20133135","DOI":"10.1161\/01.CIR.103.25.3129"},{"key":"key\n\t\t\t\t20180110092332_R23","doi-asserted-by":"crossref","unstructured":"L\u00fcscher TF, Diederich D, Weber E, Vanhoutte PM, Buhler FR. Endothelium\u2010dependent responses in carotid and renal arteries of normotensive and hypertensive rats. Hypertension1988; 11: 573\u2013578","DOI":"10.1161\/01.HYP.11.6.573"},{"key":"key\n\t\t\t\t20180110092332_R24","doi-asserted-by":"crossref","unstructured":"Intengan HD, Schiffrin EL. Mechanical properties of mesenteric resistance arteries from Dahl salt\u2010resistant and salt\u2010sensitive rats: role of endothelin\u20101. J Hypertens1998; 16: 1907\u20131912","DOI":"10.1097\/00004872-199816121-00009"},{"key":"key\n\t\t\t\t20180110092332_R25","unstructured":"Mantero F, Lucarelli G. Aldosterone antagonists in hypertension and heart failure. Ann Endocrinol (Paris)2000; 61: 52\u201360"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/16\/11\/2146\/23368829\/162146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T04:03:04Z","timestamp":1583294584000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/ndt\/article\/16\/11\/2146\/1932963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,1]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2001,11]]},"published-print":{"date-parts":[[2001,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/16.11.2146","relation":{},"ISSN":["1460-2385","0931-0509"],"issn-type":[{"value":"1460-2385","type":"electronic"},{"value":"0931-0509","type":"print"}],"subject":[],"published-other":{"date-parts":[[2001,11]]},"published":{"date-parts":[[2001,11,1]]}}}