{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:29:55Z","timestamp":1787009395483,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1092597"],"award-info":[{"award-number":["1092597"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1098815"],"award-info":[{"award-number":["1098815"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NHMRC Research Fellowships","award":["1106716"],"award-info":[{"award-number":["1106716"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in people on hemodialysis (HD). Cardiovascular outcomes are reported infrequently and inconsistently across trials in HD. This study aimed to identify the priorities of patients\/caregivers and health professionals (HPs) for CVD outcomes to be incorporated into a core outcome set reported in all HD trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In an international online survey, participants rated the absolute importance of 10 cardiovascular outcomes (derived from a systematic review) on a 9-point Likert scale, with 7\u20139 being critically important. The relative importance was determined using a best\u2013worst scale. Likert means, medians and proportions and best\u2013worst preference scores were calculated for each outcome. Comments were thematically analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants included 127 (19%) patients\/caregivers and 549 (81%) HPs from 53 countries, of whom 530 (78%) completed the survey in English and 146 (22%) in Chinese. All but one cardiovascular outcome (\u2018valve replacement\u2019) was rated as critically important (Likert 7\u20139) by all participants; \u2018sudden cardiac death\u2019, \u2018heart attack\u2019, \u2018stroke\u2019 and \u2018heart failure\u2019 were all rated at the top by patients\/caregivers (median Likert score 9). Patients\/caregivers ranked the same four outcomes as the most important outcomes with mean preference scores of 6.2 (95% confidence interval 4.8\u20137.5), 5.9 (4.6\u20137.2), 5.3 (4.0\u20136.6) and 4.9 (3.6\u20136.3), respectively. The same four outcomes were ranked most highly by HPs. We identified five themes underpinning the prioritization of outcomes: \u2018clinical equipoise and potential for intervention\u2019, \u2018specific or attributable to HD\u2019, \u2018severity or impact on the quality of life\u2019, \u2018strengthen knowledge and education\u2019, and \u2018inextricably linked burden and risk\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients and HPs believe that all cardiovascular outcomes are of critical importance but consistently identify sudden cardiac death, myocardial infarction, stroke and heart failure as the most important outcomes to be measured in all HD trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfaa008","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T07:33:24Z","timestamp":1579592004000},"page":"1761-1769","source":"Crossref","is-referenced-by-count":11,"title":["Identifying critically important cardiovascular outcomes for trials in hemodialysis: an international survey with patients, caregivers and health professionals"],"prefix":"10.1093","volume":"35","author":[{"given":"Emma","family":"O\u2019Lone","sequence":"first","affiliation":[{"name":"Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia"},{"name":"Centre for Kidney Research, Children\u2019s Hospital at Westmead, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9740-712X","authenticated-orcid":false,"given":"Martin","family":"Howell","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, University of Sydney, Sydney, NSW, 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