{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:24:44Z","timestamp":1758817484291,"version":"3.37.3"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T00:00:00Z","timestamp":1584144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swiss University Hospitals"},{"name":"Funda\u00e7\u00e3o Pesquisa e Desenvolvimento Humanitario"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients returning to dialysis after graft loss have high early morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the Swiss Transplant Cohort Study to describe the current practice and outcomes in Switzerland. All patients who received a renal allograft between May 2008 and December 2014 were included. The patients with graft loss were divided into two groups depending on whether the graft loss occurred within 1\u2009year after transplantation (early graft loss group) or later (late graft loss group). Patients with primary non-function who never gained graft function were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy-seven out of 1502 patients lost their graft during follow-up, 40 within 1\u2009year after transplantation. Eleven patients died within 30\u2009days after allograft loss. Patient survival was 86, 81 and 74% at 30, 90 and 365\u2009days after graft loss, respectively. About 92% started haemodialysis, 62% with definitive vascular access, which was associated with decreased mortality (hazard ratio = 0.28). At the time of graft loss, most patients were on triple immunosuppressive therapy with significant reduction after nephrectomy. One year after graft loss, 77.5% (31 of 40) of patients in the early and 43.2% (16 out of 37) in the late-loss group had undergone nephrectomy. Three years after graft loss, 36% of the patients with early and 12% with late graft loss received another allograft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, our data illustrate high mortality, and a high number of allograft nephrectomies and re-transplantations. Patients commencing haemodialysis with a catheter had significantly higher mortality than patients with definitive access. The role of immunosuppression reduction and allograft nephrectomy as interdependent factors for mortality and re-transplantation needs further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfaa037","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T12:10:11Z","timestamp":1580991011000},"page":"2182-2190","source":"Crossref","is-referenced-by-count":7,"title":["Dialysis after graft loss: a Swiss experience"],"prefix":"10.1093","volume":"35","author":[{"given":"Marco","family":"Bonani","sequence":"first","affiliation":[{"name":"Division of Nephrology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Achermann","sequence":"additional","affiliation":[{"name":"Department Transplant Immunology and Nephrology, University Basel Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Seeger","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Scharfe","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Clinical Trial Unit, University Basel Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schaub","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Clinical Trial Unit, University Basel Hospital, Basel, 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Hadaya","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Geneva University Hospital, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf P","family":"W\u00fcthrich","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fehr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kantonsspital Graub\u00fcnden, Chur, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Segerer","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University Hospital Z\u00fcrich, Z\u00fcrich, Switzerland"},{"name":"Division of Nephrology, Dialysis and Transplantation, Kantonsspital Aarau, Aarau, 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