{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:01:44Z","timestamp":1763535704059,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004017","name":"Japanese Association of Dialysis Physicians","doi-asserted-by":"publisher","award":["#H28-15"],"award-info":[{"award-number":["#H28-15"]}],"id":[{"id":"10.13039\/501100004017","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Encapsulating peritoneal sclerosis (EPS) is an uncommon but life-threatening complication of peritoneal dialysis (PD) therapy. The causative factors of EPS remain unclear. Pathological studies of the peritoneum affected by EPS and relationships with clinical factors including PD solutions remain lacking. The objective of this study was to examine peritoneal samples from EPS patients and to identify the associations of peritoneal pathology with different clinical factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Peritoneal specimens were obtained at the time of surgical enterolysis in Tsuchiya General Hospital from 1993 to 2016. A total of 223 PD patients were enrolled and analyzed. Tissues were fixed with formalin and processed with hematoxylin and eosin and Masson\u2019s trichrome staining, as well as immunohistochemical staining for CD31 and CD68.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Evaluations could be made in 174 patients who received surgical enterolysis. Conventional or pH-neutral low-glucose degradation product PD solutions were utilized during PD treatment. The conventional PD solution group showed less angiogenesis (P\u2009=\u20090.013) but more severe vasculopathy, in the form of a lower ratio of luminal diameter to vessel diameter (L\/V ratio) (P\u2009&amp;lt;\u20090.001) in association with longer PD treatment. Multivariate Cox proportional hazard models revealed that L\/V ratio (per 0.1 increase, hazard ratio\u2009=\u20090.88, 95% confidence interval 0.77\u20130.99, P\u2009=\u20090.047) was significantly associated with a lower incidence of EPS relapse. In contrast, most of the cases in the pH-neutral solution group showed milder vasculopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The pathology of EPS differed between conventional and pH-neutral solution groups. Vasculopathy was related to the development and relapse of EPS in the conventional solution group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfaa073","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T20:09:16Z","timestamp":1584994156000},"page":"1519-1526","source":"Crossref","is-referenced-by-count":14,"title":["Vasculopathy plays an important role during the development and relapse of encapsulating peritoneal sclerosis with conventional peritoneal dialysis solutions"],"prefix":"10.1093","volume":"36","author":[{"given":"Mitsuhiro","family":"Tawada","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan"},{"name":"Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Banshodani","sequence":"additional","affiliation":[{"name":"Department of Surgery and Artificial Organs, Akane-Foundation, Tsuchiya General Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Surgery and Artificial Organs, Akane-Foundation, Tsuchiya General Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadanori","family":"Shintaku","sequence":"additional","affiliation":[{"name":"Department of Surgery and Artificial Organs, Akane-Foundation, Tsuchiya General Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kinashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Katsuno","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Kawanishi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Artificial Organs, Akane-Foundation, Tsuchiya General Hospital, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"2021072609002516000_gfaa073-B1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ki.2010.16","article-title":"Encapsulating peritoneal sclerosis: incidence, predictors, and outcomes","volume":"77","author":"Johnson","year":"2010","journal-title":"Kidney Int"},{"key":"2021072609002516000_gfaa073-B2","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1177\/089686080002004S04","article-title":"Encapsulating peritoneal sclerosis: definition, etiology, diagnosis, and treatment. International Society for Peritoneal Dialysis Ad Hoc Committee on Ultrafiltration Management in Peritoneal Dialysis","volume":"20 (Suppl 4","author":"Kawaguchi","year":"2000","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nrneph.2011.93","article-title":"Encapsulating peritoneal sclerosis: the state of affairs","volume":"7","author":"Korte","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"2021072609002516000_gfaa073-B4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/089686080902900602","article-title":"Length of time on peritoneal dialysis and encapsulating peritoneal sclerosis: position paper for ISPD","volume":"29","author":"Brown","year":"2009","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0272-6386(04)00953-9","article-title":"Encapsulating peritoneal sclerosis in Japan: a prospective, controlled, multicenter study","volume":"44","author":"Kawanishi","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"2021072609002516000_gfaa073-B6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3747\/pdi.2010.00167","article-title":"Risk factors associated with encapsulating peritoneal sclerosis in Dutch EPS study","volume":"31","author":"Korte","year":"2011","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/ndt\/13.1.154","article-title":"Sclerosing peritonitis: the experience in Australia","volume":"13","author":"Rigby","year":"1998","journal-title":"Nephrol Dial Transplant"},{"key":"2021072609002516000_gfaa073-B8","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/ndt\/gfp677","article-title":"Risk factors for developing encapsulating peritoneal sclerosis in the icodextrin era of peritoneal dialysis prescription","volume":"25","author":"Habib","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"2021072609002516000_gfaa073-B9","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1093\/ndt\/gfm171","article-title":"Increasing incidence of severe encapsulating peritoneal sclerosis after kidney transplantation","volume":"22","author":"Korte","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"2021072609002516000_gfaa073-B10","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1093\/ndt\/gfp008","article-title":"The Pan-Thames EPS study: treatment and outcomes of encapsulating peritoneal sclerosis","volume":"24","author":"Balasubramaniam","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"2021072609002516000_gfaa073-B11","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1681\/ASN.2009070694","article-title":"The pathophysiology of the peritoneal membrane","volume":"21","author":"Devuyst","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2021072609002516000_gfaa073-B12","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1177\/089686080502504S04","article-title":"Pathology of encapsulating peritoneal sclerosis","volume":"25 (Suppl 4","author":"Honda","year":"2005","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B13","doi-asserted-by":"crossref","first-page":"e0154644","DOI":"10.1371\/journal.pone.0154644","article-title":"Vascular endothelial cell injury is an important factor in the development of encapsulating peritoneal sclerosis in long-term peritoneal dialysis patients","volume":"11","author":"Tawada","year":"2016","journal-title":"PLoS One"},{"key":"2021072609002516000_gfaa073-B14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3747\/pdi.2018.00042","article-title":"Surgical treatment for encapsulating peritoneal sclerosis: 24 years\u2019 experience","volume":"39","author":"Kawanishi","year":"2019","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B15","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10157-018-1679-7","article-title":"Effects of long-term treatment with low-GDP, pH-neutral solutions on peritoneal membranes in peritoneal dialysis patients","volume":"23","author":"Tawada","year":"2019","journal-title":"Clin Exp Nephrol"},{"key":"2021072609002516000_gfaa073-B16","doi-asserted-by":"crossref","first-page":"F721","DOI":"10.1152\/ajprenal.00368.2009","article-title":"Connective tissue growth factor (CTGF\/CCN2) is increased in peritoneal dialysis patients with high peritoneal solute transport rate","volume":"298","author":"Mizutani","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"2021072609002516000_gfaa073-B17","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1681\/ASN.2012030226","article-title":"TGF-beta1 promotes lymphangiogenesis during peritoneal fibrosis","volume":"24","author":"Kinashi","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"2021072609002516000_gfaa073-B18","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2215\/CJN.03630807","article-title":"Impact of uremia, diabetes, and peritoneal dialysis itself on the pathogenesis of peritoneal sclerosis: a quantitative study of peritoneal membrane morphology","volume":"3","author":"Honda","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021072609002516000_gfaa073-B19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.V132470","article-title":"Morphologic changes in the peritoneal membrane of patients with renal disease","volume":"13","author":"Williams","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"2021072609002516000_gfaa073-B20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3747\/pdi.2013.00074","article-title":"Encapsulating peritoneal sclerosis in the era of a multi-disciplinary approach based on biocompatible solutions: the NEXT-PD study","volume":"34","author":"Nakayama","year":"2014","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B21","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1177\/089686080102103S11","article-title":"Long-Term Peritoneal Dialysis Study Group. Encapsulating peritoneal sclerosis in Japan: prospective multicenter controlled study","volume":"21 (Suppl 3","author":"Kawanishi","year":"2001","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B22","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2215\/CJN.01260209","article-title":"Encapsulating peritoneal sclerosis in the new millennium: a national cohort study","volume":"4","author":"Brown","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"2021072609002516000_gfaa073-B23","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3747\/pdi.2017.00018","article-title":"Length of time on peritoneal dialysis and encapsulating peritoneal sclerosis - position paper for ISPD: 2017 update","volume":"37","author":"Brown","year":"2017","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1744-9987.2007.00538.x","article-title":"Comparison between the pathology of encapsulating sclerosis and simple sclerosis of the peritoneal membrane in chronic peritoneal dialysis","volume":"12","author":"Sherif","year":"2008","journal-title":"Therapher Dial"},{"key":"2021072609002516000_gfaa073-B25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3747\/pdi.2011.00096","article-title":"Increased lymphatic vessels in patients with encapsulating peritoneal sclerosis","volume":"32","author":"Yaginuma","year":"2012","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B26","doi-asserted-by":"crossref","first-page":"e48647","DOI":"10.1371\/journal.pone.0048647","article-title":"Histological criteria for encapsulating peritoneal sclerosis - a standardized approach","volume":"7","author":"Braun","year":"2012","journal-title":"PLoS One"},{"key":"2021072609002516000_gfaa073-B27","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1681\/ASN.2014090939","article-title":"Interstitial fibrosis restricts osmotic water transport in encapsulating peritoneal sclerosis","volume":"26","author":"Morelle","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2021072609002516000_gfaa073-B28","doi-asserted-by":"crossref","first-page":"e112050","DOI":"10.1371\/journal.pone.0112050","article-title":"Patients with encapsulating peritoneal sclerosis have increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-beta1, and vascular endothelial growth factor","volume":"9","author":"Abrahams","year":"2014","journal-title":"PLoS One"},{"key":"2021072609002516000_gfaa073-B29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5414\/CNP68125","article-title":"Successful treatment of fulminant encapsulating peritoneal sclerosis following fungal peritonitis with tamoxifen","volume":"68","author":"Gupta","year":"2007","journal-title":"Clin Nephrol"},{"key":"2021072609002516000_gfaa073-B30","first-page":"19","article-title":"Time is not always the matter: an instance of encapsulating peritoneal sclerosis developing in a patient on peritoneal dialysis for a short term","volume":"32","author":"De Oleo","year":"2016","journal-title":"Adv Perit Dial"},{"key":"2021072609002516000_gfaa073-B31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/ki.1997.22","article-title":"Immunohistochemical detection of advanced glycosylation end-products in the peritoneum and its possible pathophysiological role in CAPD","volume":"51","author":"Nakayama","year":"1997","journal-title":"Kidney Int"},{"key":"2021072609002516000_gfaa073-B32","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/ndt\/14.6.1541","article-title":"Accumulation of advanced glycation end products in the peritoneal vasculature of continuous ambulatory peritoneal dialysis patients with low ultra-filtration","volume":"14","author":"Honda","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"2021072609002516000_gfaa073-B33","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3747\/pdi.2011.00270","article-title":"Neutral solution low in glucose degradation products is associated with less peritoneal fibrosis and vascular sclerosis in patients receiving peritoneal dialysis","volume":"33","author":"Kawanishi","year":"2013","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/089686080802800102","article-title":"Endothelial glycocalyx and the peritoneal barrier","volume":"28","author":"Flessner","year":"2008","journal-title":"Perit Dial Int"},{"key":"2021072609002516000_gfaa073-B35","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1242\/jcs.017897","article-title":"The role of adherens junctions and VE-cadherin in the control of vascular permeability","volume":"121","author":"Dejana","year":"2008","journal-title":"J Cell Sci"},{"key":"2021072609002516000_gfaa073-B36","doi-asserted-by":"crossref","first-page":"L371","DOI":"10.1152\/ajplung.00175.2004","article-title":"Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity","volume":"289","author":"Predescu","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2021072609002516000_gfaa073-B37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10456-008-9099-z","article-title":"Vascular permeability, vascular hyperpermeability and angiogenesis","volume":"11","author":"Nagy","year":"2008","journal-title":"Angiogenesis"},{"key":"2021072609002516000_gfaa073-B38","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.3748\/wjg.v24.i28.3101","article-title":"Encapsulating peritoneal sclerosis","volume":"24","author":"Danford","year":"2018","journal-title":"World J Gastroenterol"},{"key":"2021072609002516000_gfaa073-B39","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1177\/089686080502504S12","article-title":"Recommendations on the management of encapsulating peritoneal sclerosis in Japan, 2005: diagnosis, predictive markers, treatment, and preventive measures","volume":"25 (Suppl 4","author":"Kawaguchi","year":"2005","journal-title":"Perit Dial Int"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/36\/8\/1519\/39302031\/gfaa073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/36\/8\/1519\/39302031\/gfaa073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T09:02:47Z","timestamp":1627290167000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/36\/8\/1519\/5841750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,21]]},"references-count":39,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,5,21]]},"published-print":{"date-parts":[[2021,7,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfaa073","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"type":"print","value":"0931-0509"},{"type":"electronic","value":"1460-2385"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2020,5,21]]}}}