{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:55:24Z","timestamp":1790315724620,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["#25461215"],"award-info":[{"award-number":["#25461215"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["#19K08739"],"award-info":[{"award-number":["#19K08739"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["#17H04667"],"award-info":[{"award-number":["#17H04667"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis","award":["H23 nanchi-ippan-004"],"award-info":[{"award-number":["H23 nanchi-ippan-004"]}]},{"name":"Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis","award":["H26 nanchi-ippan-044"],"award-info":[{"award-number":["H26 nanchi-ippan-044"]}]},{"name":"Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis","award":["H29 nanchi-ippan-018"],"award-info":[{"award-number":["H29 nanchi-ippan-018"]}]},{"name":"Intractable Renal Disease","award":["H23 nanchi-ippan-033"],"award-info":[{"award-number":["H23 nanchi-ippan-033"]}]},{"name":"Intractable Renal Disease","award":["H26 nanchi-ippan-042"],"award-info":[{"award-number":["H26 nanchi-ippan-042"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18ek0109354"],"award-info":[{"award-number":["JP18ek0109354"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The detection of leukocyte-derived CD11b (\u03b1 subunit of integrin Mac-1) and CD163 (scavenger receptor) in urine may reflect renal inflammation in antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN). The objective of this study was to evaluate the clinical significance of urinary CD11b (U-CD11b) and CD163 (U-CD163) in ANCA-GN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>U-CD11b and U-CD163 were examined using enzyme-linked immunosorbent assay in ANCA-GN urine samples from our institutional cohort (n\u2009=\u200988) and a nationwide cohort (n\u2009=\u2009138), and their association with renal histology was subsequently analyzed. Logistic regression analyses were performed on a nationwide ANCA cohort to determine the associations of the two urinary molecules with renal remission failure at 6\u2009months or with yearly estimated glomerular filtration rate (eGFR) slope over a 24-month observation period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>U-CD11b and U-CD163 were significantly associated with cellular crescent formation and leukocyte accumulation in glomerular crescents. With regard to interstitial inflammation, both levels of U-CD11b and U-CD163 at diagnosis remarkably increased in ANCA-GN compared with the levels observed in nonglomerular kidney disorders including nephrosclerosis, immunoglobulin G4-related\u00a0disease and tubulointerstitial nephritis; however, the presence of U-CD11b alone was significantly correlated with tubulointerstitial leukocyte infiltrates. Although neither U-CD11b nor U-CD163 at diagnosis was associated with remission failure at 6\u2009months, multivariate analysis demonstrated that the baseline U-CD11b levels were significantly associated with the increase in eGFR following immunosuppressive therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although both U-CD11b and U-CD163 reflect renal leukocyte accumulation, U-CD11b at diagnosis provides additional clinical value by predicting the recovery rate after the treatment of ANCA-GN.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfaa097","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T11:09:34Z","timestamp":1586430574000},"page":"1452-1463","source":"Crossref","is-referenced-by-count":10,"title":["Clinical impact of urinary CD11b and CD163 on the renal outcomes of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis"],"prefix":"10.1093","volume":"36","author":[{"given":"Yuki","family":"Yokoe","sequence":"first","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"},{"name":"Department of Nephrology, Fujita Health University Graduate School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-845X","authenticated-orcid":false,"given":"Naotake","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"},{"name":"Department of Nephrology, Fujita Health University Graduate School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akimitsu","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munetoshi","family":"Karasawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1839-1180","authenticated-orcid":false,"given":"Takaya","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhide","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawako","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Katsuno","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joichi","family":"Usui","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Tsukuba, Tsukuba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, University of Tsukuba, Tsukuba, 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Arimura","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan"},{"name":"Department of Internal Medicine, Kichijoji Asahi Hospital, Musashino, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yuzawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fujita Health University Graduate School of Medicine, Toyoake, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Dobashi","sequence":"additional","affiliation":[{"name":"Division 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