{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:16:56Z","timestamp":1790662616492,"version":"4.1.0"},"reference-count":125,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","award":["17OKG18"],"award-info":[{"award-number":["17OKG18"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.<\/jats:p>","DOI":"10.1093\/ndt\/gfaa123","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T03:21:40Z","timestamp":1588303300000},"page":"1976-1985","source":"Crossref","is-referenced-by-count":21,"title":["Iron deficiency after kidney transplantation"],"prefix":"10.1093","volume":"36","author":[{"given":"Joanna Sophia J","family":"Vinke","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marith I","family":"Francke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele F","family":"Eisenga","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A","family":"Hesselink","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin H","family":"de Borst","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"2021111803021934300_gfaa123-B1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","article-title":"A systematic analysis of global anemia burden from 1990 to 2010","volume":"123","author":"Kassebaum","year":"2014","journal-title":"Blood"},{"key":"2021111803021934300_gfaa123-B2","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/tri.12821","article-title":"Iron deficiency, anemia, and mortality in renal transplant recipients","volume":"29","author":"Eisenga","year":"2016","journal-title":"Transpl Int"},{"key":"2021111803021934300_gfaa123-B3","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1046\/j.1600-6143.2004.00604.x","article-title":"Percentage of hypochromic red blood cells is an independent risk factor for mortality in kidney transplant 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