{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:12:14Z","timestamp":1790719934840,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Ministry of Higher Education Research and Innovation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several models have been proposed to predict kidney graft failure in adult recipients but none in younger recipients. Our objective was to propose a dynamic prediction model for graft failure in young kidney transplant recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 793 kidney transplant recipients waitlisted before the age of 18\u2009years who received a first kidney transplantation before the age of 21\u2009years in France in 2002\u201313 and survived &amp;gt;90\u2009days with a functioning graft. We used a Cox model including baseline predictors only (sex, age at transplant, primary kidney disease, dialysis duration, donor type and age, human leucocyte antigen matching, cytomegalovirus serostatus, cold ischaemia time and delayed graft function) and two joint models also accounting for post-transplant estimated glomerular filtration rate (eGFR) trajectory. Predictive performances were evaluated using a cross-validated area under the curve (AUC) and R2 curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>When predicting the risk of graft failure from any time within the first 7\u00a0years after paediatric kidney transplantation, the predictions for the following 3 or 5\u00a0years were accurate and much better with the joint models than with the Cox model (AUC ranged from 0.83 to 0.91 for the joint models versus 0.56 to 0.64 for the Cox model).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Accounting for post-transplant eGFR trajectory strongly increased the accuracy of graft failure prediction in young kidney transplant recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfaa180","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T23:35:53Z","timestamp":1592523353000},"page":"927-935","source":"Crossref","is-referenced-by-count":17,"title":["Dynamic prediction models for graft failure in paediatric kidney transplantation"],"prefix":"10.1093","volume":"36","author":[{"given":"R\u00e9mi","family":"Kabor\u00e9","sequence":"first","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, University of Bordeaux, UMR1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Ferrer","sequence":"additional","affiliation":[{"name":"INSERM, Bordeaux Population Health Research Center, University of Bordeaux, UMR1219, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Couchoud","sequence":"additional","affiliation":[{"name":"Agence de la Biom\u00e9decine, REIN Registry, La 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