{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:02:33Z","timestamp":1774620153166,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100016034","name":"French Kidney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016034","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Paris Est Cr\u00e9teil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The recent success achieved with the use of B cell-depleting agents in some patients with minimal change nephrotic syndrome (MCNS) suggests an unexpected role for B lymphocytes in the pathogenesis of this immune-mediated glomerular disease. Nevertheless, no extensive B-cell phenotyping analysis has ever been performed in untreated adult patients soon after MCNS diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We investigated the distribution of the different B-cell subpopulations in 22 untreated adult patients with biopsy-proven MCNS [MCNS relapse (MCNS-Rel)]. We compared these data with those for 24 healthy controls, 13 MCNS patients in remission (with no specific treatment) and 19 patients with idiopathic membranous nephropathy (IMN).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with MCNS-Rel or IMN had higher proteinuria and lower serum albumin and gammaglobulin levels (P\u2009&amp;lt;\u20090.0001 for all comparisons) than MCNS patients in remission. Plasmablasts were the only B-cell subsets present at significantly higher levels in MCNS-Rel patients than in the patients of the other three groups (P\u2009&amp;lt;\u20090.05 for all comparisons). The lower albumin levels and higher proteinuria levels were positively correlated with the percentage of circulating plasmablasts (Spearman test\u2019s \u03c1\u2009=\u2009\u22120.54, P\u2009=\u20090.01 and \u03c1\u2009=\u20090.65, P\u2009=\u20090.002, respectively). Similarly, the increase of immunoglobulin M (IgM) and the decrease of IgG levels were significantly associated with the percentage of plasmablasts in MCNS-Rel patients (Spearman\u2019s \u03c1\u2009=\u20090.36, P\u2009=\u20090.01 and Spearman\u2019s \u03c1\u2009=\u2009\u22120.60, P\u2009=\u20090.01, respectively). Increased production of interleukin (IL)-21, IL-6 and B-cell activating factor (BAFF) in the serum of MCNS-Rel patients was found significantly correlated with the percentage of plasmablasts (\u03c1\u2009=\u20090.72, P\u2009=\u20090.0002, \u03c1\u2009=\u20090.49, P\u2009=\u20090.04 and \u03c1\u2009=\u20090.62, P\u2009=\u20090.009, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>An increase in the proportion of circulating plasmablasts seems to be a hallmark of untreated MCNS in adult patients. Further studies are required to more precisely determine the phenotype and functions of these cells.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfaa279","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T19:38:39Z","timestamp":1602531519000},"page":"609-617","source":"Crossref","is-referenced-by-count":36,"title":["Circulating plasmablasts and high level of BAFF are hallmarks of minimal change nephrotic syndrome in adults"],"prefix":"10.1093","volume":"36","author":[{"given":"Julie","family":"Oniszczuk","sequence":"first","affiliation":[{"name":"Assistance Publique des H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Henri Mondor, Service de N\u00e9phrologie et Transplantation, Centre de R\u00e9f\u00e9rence Maladie Rare \u00ab Syndrome N\u00e9phrotique Idiopathique \u00bb, F\u00e9d\u00e9ration Hospitalo-Universitaire \u00ab Innovative Therapy for Immune Disorders \u00bb, Cr\u00e9teil, France"},{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Beldi-Ferchiou","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pitaux Universitaires Henri Mondor, D\u00e9partement d\u2019H\u00e9matologie et Immunologie Biologiques, Cr\u00e9teil, France"},{"name":"Univ Paris Est Cr\u00e9teil, INSERM U955, IMRB, Equipe Immunor\u00e9gulation et Bioth\u00e9rapie, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Audureau","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pitaux Universitaires Henri Mondor, Service de Sant\u00e9 Publique, Unit\u00e9 de Recherche Clinique, Universit\u00e9 Paris Est Cr\u00e9teil, INSERM U955, IMRB, Equipe CEPIA, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imane","family":"Azzaoui","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM U955, IMRB, Equipe 2, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Molinier-Frenkel","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pitaux Universitaires Henri Mondor, D\u00e9partement d\u2019H\u00e9matologie et Immunologie Biologiques, Cr\u00e9teil, France"},{"name":"Univ Paris Est Cr\u00e9teil, INSERM U955, IMRB, Equipe Immunor\u00e9gulation et Bioth\u00e9rapie, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Frontera","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Karras","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Europ\u00e9en Georges Pompidou, Service de N\u00e9phrologie, Paris, France"},{"name":"Facult\u00e9 de M\u00e9decine Paris-Descartes, Universit\u00e9 de Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anissa","family":"Moktefi","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, France"},{"name":"AP-HP, H\u00f4pitaux Universitaires Henri Mondor, D\u00e9partement de Pathologie, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangeline","family":"Pillebout","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation, AP-HP, H\u00f4pital Saint Louis, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Zaidan","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pitaux Universitaires du Kremlin Bic\u00eatre, Service de N\u00e9phrologie-Dialyse-Transplantation, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalil","family":"El Karoui","sequence":"additional","affiliation":[{"name":"Assistance Publique des H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Henri Mondor, Service de N\u00e9phrologie et Transplantation, Centre de R\u00e9f\u00e9rence Maladie Rare \u00ab Syndrome N\u00e9phrotique Idiopathique \u00bb, F\u00e9d\u00e9ration Hospitalo-Universitaire \u00ab Innovative Therapy for Immune Disorders \u00bb, Cr\u00e9teil, France"},{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Delfau-Larue","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pitaux Universitaires Henri Mondor, D\u00e9partement d\u2019H\u00e9matologie et Immunologie Biologiques, Cr\u00e9teil, France"},{"name":"Univ Paris Est Cr\u00e9teil, INSERM U955, IMRB, Equipe 9, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"H\u00e9nique","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Ollero","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dil","family":"Sahali","sequence":"additional","affiliation":[{"name":"Assistance Publique des H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Henri Mondor, Service de N\u00e9phrologie et Transplantation, Centre de R\u00e9f\u00e9rence Maladie Rare \u00ab Syndrome N\u00e9phrotique Idiopathique \u00bb, F\u00e9d\u00e9ration Hospitalo-Universitaire \u00ab Innovative Therapy for Immune Disorders \u00bb, Cr\u00e9teil, France"},{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Mah\u00e9vas","sequence":"additional","affiliation":[{"name":"Univ Paris Est Cr\u00e9teil, INSERM U955, IMRB, Equipe 2, Cr\u00e9teil, France"},{"name":"AP-HP, H\u00f4pitaux Universitaires Henri Mondor, Service de M\u00e9decine interne, Centre de R\u00e9f\u00e9rence Maladie Rare \u00ab Cytop\u00e9nies Auto-immunes \u00bb, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"Assistance Publique des H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux Universitaires Henri Mondor, Service de N\u00e9phrologie et Transplantation, Centre de R\u00e9f\u00e9rence Maladie Rare \u00ab Syndrome N\u00e9phrotique Idiopathique \u00bb, F\u00e9d\u00e9ration Hospitalo-Universitaire \u00ab Innovative Therapy for Immune Disorders \u00bb, Cr\u00e9teil, France"},{"name":"Univ Paris Est Cr\u00e9teil, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955, Institut Mondor de Recherche Biom\u00e9dicale (IMRB), Equipe 21, Cr\u00e9teil, 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