{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:53:56Z","timestamp":1768010036358,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Only few studies with inconsistent results comparing the relative risk of cardiac mortality between peritoneal dialysis (PD) and hemodialysis (HD). Switches between renal replacement therapy (RRT) modalities render objective assessment of survival benefits a greater challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrieved from Taiwan\u2019s National Health Insurance Database from 1 January 2006 to 31 December 2015. We included 13\u2009662 and 41\u2009047 long-term dialysis patients in a propensity score matching study design and a time-varying study design, respectively, to compare major adverse cardiovascular events (MACEs) between patients receiving PD and HD. We also included 109\u2009256 dialysis patients to compare the all-cause mortality among different RRT modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For MACE, the hazard ratio (HR) for PD patients compared to HD patients was 0.95 [95% confidence interval (CI) 0.89\u20131.02] in the propensity score study design and 1.06 (95% CI 1.01\u20131.12) in the time-varying study design. For all-cause mortality, the HR for PD patients compared to HD patients was 1.09 (95% CI 1.05\u20131.13) in the propensity score study design and 1.13 (95% CI 1.09\u20131.17) in the time-varying study design. The HR for death was higher at a level of statistical significance for females (1.21, 95% CI 1.15\u20131.28), patients \u226565\u2009years old (1.30, 95% CI 1.24\u20131.36) and diabetes mellitus (DM; 1.28, 95% CI 1.22\u20131.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The HR for MACE is significantly higher among PD patients in time-varying design analysis. In addition, all-cause mortality was higher in PD patients compared to patients with HD, especially in those who were aged \u226565\u2009years, female or DM.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfaa282","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T11:38:18Z","timestamp":1602761898000},"page":"901-908","source":"Crossref","is-referenced-by-count":15,"title":["Impact of dialysis modality on major adverse cardiovascular events and all-cause mortality: a national population-based study"],"prefix":"10.1093","volume":"36","author":[{"given":"Ping-Jen","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, Taitung Mackay Memorial Hospital, Taitung, Taiwan"},{"name":"Department of Internal Medicine, Division of Gastroenterology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County, Taiwan"},{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Chin","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Internal Medicine, Division of Cardiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"},{"name":"Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"},{"name":"TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan"},{"name":"Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan"},{"name":"Department of Primary Care Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"},{"name":"Department of Internal Medicine, Division of Nephrology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai-Szu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"},{"name":"TMU Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Internal Medicine, Division of Nephrology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"2021042619272115100_gfaa282-B1","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1046\/j.1523-1755.2003.00321.x","article-title":"Effect of starting with hemodialysis compared with 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