{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:29:44Z","timestamp":1740130184575,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100016298","name":"ERA-EDTA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>\u2002<\/jats:title>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Literature on recovery of kidney function (RKF) in patients with end-stage kidney disease treated with maintenance dialysis (i.e. &amp;gt;90\u2009days) is limited. We assessed the incidence of RKF and its associated characteristics in a European cohort of dialysis patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included adult patients from the European Renal Association\u2013European Dialysis and Transplant Association Registry who started maintenance dialysis in 1997\u20132016. Sustained RKF was defined as permanent discontinuation of dialysis. Temporary discontinuation of \u226530\u2009days (non-sustained RKF) was also evaluated. Factors associated with RKF adjusted for potential confounders were studied using Cox regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>RKF occurred in 7657 (1.8%) of 440\u2009996 patients, of whom 71% experienced sustained RKF. Approximately 90% of all recoveries occurred within the first 2\u2009years after Day 91 of dialysis. Of patients with non-sustained RKF, 39% restarted kidney replacement therapy within 1\u2009year. Sustained RKF was strongly associated with the following underlying kidney diseases (as registered by the treating physician): tubular necrosis (irreversible) or cortical necrosis {adjusted hazard ratio [aHR] 20.4 [95% confidence interval (CI) 17.9\u201323.1]}, systemic sclerosis [aHR 18.5 (95% CI 13.8\u201324.7)] and haemolytic uremic syndrome [aHR 17.3 (95% CI 13.9\u201321.6)]. Weaker associations were found for haemodialysis as a first dialysis modality [aHR 1.5 (95% CI 1.4\u20131.6)] and dialysis initiation at an older age [aHR 1.8 (95% CI 1.6\u20132.0)] or in a more recent time period [aHR 2.4 (95% CI 2.1\u20132.7)].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Definitive discontinuation of maintenance dialysis is a rare and not necessarily an early event. Certain clinical characteristics, but mostly the type of underlying kidney disease, are associated with a higher likelihood of RKF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfaa368","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T03:55:08Z","timestamp":1607572508000},"page":"1078-1087","source":"Crossref","is-referenced-by-count":1,"title":["Recovery of kidney function in patients treated with maintenance dialysis\u2014a report from the ERA-EDTA\u00a0Registry"],"prefix":"10.1093","volume":"36","author":[{"given":"Lily","family":"Jakulj","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Nephrology, Dianet Dialysis Center, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-2669","authenticated-orcid":false,"given":"Anneke","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, European Renal Association\u2013European Dialysis and Transplant Association\u00a0Registry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"\u00c5sberg","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"de Meester","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Hypertension, Dutch-speaking Belgian Renal Registry (NBVN), Sint-Niklaas, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Santiuste de Pablos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Murcia Renal Registry, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain"},{"name":"CIBER Epidemiolog\u00edca y Salud P\u00fablican, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Helve","sequence":"additional","affiliation":[{"name":"Finnish Registry for Kidney Diseases and Abdominal Center Nephrology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc H","family":"Hemmelder","sequence":"additional","affiliation":[{"name":"Dutch Renal Registry Renine, Nefrovisie Foundation, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Hertig","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique\u2013H\u00f4pitaux de Paris, Kidney Transplantation, H\u00f4pital de la Piti\u00e9 Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Arici","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9100-1575","authenticated-orcid":false,"given":"Samira","family":"Bell","sequence":"additional","affiliation":[{"name":"Scottish Renal Registry, Meridian Court, ISD Scotland, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucile","family":"Mercadal","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale,\u00a0Center for Renal and Cardiovascular Epidemiology, Villejuif, France"},{"name":"Department of Nephrology and Renal Transplantation, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital de La Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Diaz-Corte","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitario Central de Asturias, Oviedo, Spain"},{"name":"Red de Investigaci\u00f3n Renal, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runolfur","family":"Palsson","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Landsp\u00edtali\u2013The National University Hospital of Iceland, Reykjavik, Iceland"},{"name":"Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Benitez Sanchez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Juan Ram\u00f3n Jim\u00e9nez, Huelva, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kerschbaum","sequence":"additional","affiliation":[{"name":"Department for Internal Medicine IV\u2013Nephrology and Hypertension, Austrian Dialysis and Transplant Registry, Medical University Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Collart","sequence":"additional","affiliation":[{"name":"French-Belgian ESRD Registry, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad A","family":"Massy","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Ambroise Par\u00e9 University Hospital, Boulogne-Billancourt, Paris, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 1018 Team 5, Research Centre in Epidemiology and Population Health, University of Paris Ouest-Versailles-St Quentin-en-Yveline, Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitty J","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, European Renal Association\u2013European Dialysis and Transplant Association\u00a0Registry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies","family":"Noordzij","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, European Renal Association\u2013European Dialysis and Transplant Association\u00a0Registry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The 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