{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:48:24Z","timestamp":1791931704709,"version":"4.3.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII)\u2014Fondo de Investigaci\u00f3n Sanitaria","award":["FIS07\/0893"],"award-info":[{"award-number":["FIS07\/0893"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)\u2014Fondo de Investigaci\u00f3n Sanitaria","award":["FIS10\/00896"],"award-info":[{"award-number":["FIS10\/00896"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)\u2014Fondo de Investigaci\u00f3n Sanitaria","award":["FIS13\/00014"],"award-info":[{"award-number":["FIS13\/00014"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)\u2014Fondo de Investigaci\u00f3n Sanitaria","award":["FIS16\/00637"],"award-info":[{"award-number":["FIS16\/00637"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)\u2014Fondo de Investigaci\u00f3n Sanitaria","award":["FIS17\/00715"],"award-info":[{"award-number":["FIS17\/00715"]}]},{"name":"Instituto de Salud Carlos III (ISCIII)\u2014Fondo de Investigaci\u00f3n Sanitaria","award":["FIS19\/00532"],"award-info":[{"award-number":["FIS19\/00532"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In chronic kidney disease, the activation of the renin\u2013angiotensin\u2013aldosterone system (RAAS) and renal inflammation stimulates renal fibrosis and the progression to end-stage renal disease. The low levels of vitamin D receptor (VDR) and its activators (VDRAs) contribute to worsen secondary hyperparathyroidism and renal fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The 7\/8 nephrectomy model of experimental chronic renal failure (CRF) was used to examine the anti-fibrotic effects of treatment with two VDRAs, paricalcitol and calcitriol, at equivalent doses (3\/1 dose ratio) during 4\u2009weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CRF increased the activation of the RAAS, renal inflammation and interstitial fibrosis. Paricalcitol treatment reduced renal collagen I and renal interstitial fibrosis by decreasing the activation of the RAAS through renal changes in renin, angiotensin receptor 1 (ATR1) and ATR2 mRNAs levels and renal inflammation by decreasing renal inflammatory leucocytes (CD45), a desintegrin and metaloproteinase mRNA, transforming growth factor beta mRNA and protein, and maintaining E-cadherin mRNA levels. Calcitriol showed similar trends without significant changes in most of these biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Paricalcitol effectively attenuated the renal interstitial fibrosis induced by CRF through a combination of inhibitory actions on the RAAS, inflammation and epithelial\/mesenchymal transition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfaa373","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T04:23:04Z","timestamp":1608697384000},"page":"793-803","source":"Crossref","is-referenced-by-count":43,"title":["Effects of calcitriol and paricalcitol on renal fibrosis in CKD"],"prefix":"10.1093","volume":"36","author":[{"given":"Laura","family":"Mart\u00ednez-Arias","sequence":"first","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Panizo","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Alonso-Montes","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Mart\u00edn-V\u00edrgala","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Mart\u00edn-Carro","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Fern\u00e1ndez-Villabrille","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda Gil-Albert","sequence":"additional","affiliation":[{"name":"Laboratory of Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Palomo-Antequera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-1778","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Fern\u00e1ndez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Piedad","family":"Ruiz-Torres","sequence":"additional","affiliation":[{"name":"Department of System Biology, Universidad de Alcal\u00e1, Retic REDinREN-ISCIII, Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana S","family":"Dusso","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Carrillo-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge B","family":"Cannata-And\u00eda","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"},{"name":"Departament of Medicine, Universidad de Oviedo, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Naves-D\u00edaz","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"2021042619271355800_gfaa373-B1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system","volume":"110","author":"Li","year":"2002","journal-title":"J Clin Invest"},{"key":"2021042619271355800_gfaa373-B2","doi-asserted-by":"crossref","first-page":"29821","DOI":"10.1074\/jbc.M705495200","article-title":"1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter","volume":"282","author":"Yuan","year":"2007","journal-title":"J Biol Chem"},{"key":"2021042619271355800_gfaa373-B3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr Rev"},{"key":"2021042619271355800_gfaa373-B4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jsbmb.2012.06.004","article-title":"The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload","volume":"132","author":"Meems","year":"2012","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2021042619271355800_gfaa373-B5","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1093\/ndt\/gft268","article-title":"Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis","volume":"28","author":"Panizo","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"2021042619271355800_gfaa373-B6","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1093\/ndt\/gfx060","article-title":"Regulation of miR-29b and miR-30c by vitamin D receptor activators contributes to attenuate uraemia-induced cardiac fibrosis","volume":"32","author":"Panizo","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2021042619271355800_gfaa373-B7","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1681\/ASN.2006050520","article-title":"Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy","volume":"17","author":"Tan","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"2021042619271355800_gfaa373-B8","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI200320530","article-title":"Epithelial-mesenchymal transition and its implications for fibrosis","volume":"112","author":"Kalluri","year":"2003","journal-title":"J Clin Invest"},{"key":"2021042619271355800_gfaa373-B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6213872","article-title":"Vitamin D and the epithelial to mesenchymal transition","volume":"2016","author":"Larriba","year":"2016","journal-title":"Stem Cells Int"},{"key":"2021042619271355800_gfaa373-B10","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1001\/jama.2012.120","article-title":"Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial","volume":"307","author":"Thadhani","year":"2012","journal-title":"JAMA"},{"key":"2021042619271355800_gfaa373-B11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1681\/ASN.2013010103","article-title":"Effect of paricalcitol on left ventricular mass and function in CKD\u2013the OPERA trial","volume":"25","author":"Wang","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"2021042619271355800_gfaa373-B12","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/gme.0b013e3181ce6874","article-title":"Differential effects of 17beta-estradiol and raloxifene on bone and lipid metabolism in rats with chronic kidney disease and estrogen insufficiency","volume":"17","author":"Naves-Diaz","year":"2010","journal-title":"Menopause"},{"key":"2021042619271355800_gfaa373-B13","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000181994","article-title":"Experimental uremia. Description of a model producing varying degrees of stable uremia","volume":"26","author":"Ormrod","year":"1980","journal-title":"Nephron"},{"key":"2021042619271355800_gfaa373-B14","first-page":"226","article-title":"A long-term comparative study of calcitriol versus alphacalcidol in patients with secondary hyperparathyroidism on hemodialysis","volume":"26","author":"Arenas","year":"2006","journal-title":"Nefrologia"},{"key":"2021042619271355800_gfaa373-B15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2021042619271355800_gfaa373-B16","doi-asserted-by":"crossref","first-page":"e1002128","DOI":"10.1371\/journal.pbio.1002128","article-title":"Beyond bar and line graphs: time for a new data presentation paradigm","volume":"13","author":"Weissgerber","year":"2015","journal-title":"PLoS Biol"},{"key":"2021042619271355800_gfaa373-B17","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/ndt\/gfw454","article-title":"Vitamin D treatment attenuates cardiac FGF23\/FGFR4 signaling and hypertrophy in uremic rats","volume":"32","author":"Leifheit-Nestler","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2021042619271355800_gfaa373-B18","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3892\/mmr.2015.3555","article-title":"Calcitriol ameliorates renal damage in a pre-established proteinuria model","volume":"12","author":"Maquigussa","year":"2015","journal-title":"Mol Med Rep"},{"key":"2021042619271355800_gfaa373-B19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jsbmb.2010.03.026","article-title":"Myocardial effects of VDR activators in renal failure","volume":"121","author":"Mizobuchi","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2021042619271355800_gfaa373-B20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.070305","article-title":"Differential effects of vitamin D analogs on vascular calcification","volume":"22","author":"Cardus","year":"2007","journal-title":"J Bone Miner Res"},{"key":"2021042619271355800_gfaa373-B21","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1093\/ndt\/gfr555","article-title":"The effect of vitamin D derivatives on vascular calcification associated with inflammation","volume":"27","author":"Guerrero","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2021042619271355800_gfaa373-B22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2003","journal-title":"J Bone Miner Res"},{"key":"2021042619271355800_gfaa373-B23","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1074\/jbc.M408903200","article-title":"Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo","volume":"280","author":"Saito","year":"2005","journal-title":"J Biol Chem"},{"key":"2021042619271355800_gfaa373-B24","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002458","article-title":"Paricalcitol aggravates perivascular fibrosis in rats with renal insufficiency and low calcitriol","volume":"72","author":"Repo","year":"2007","journal-title":"Kidney Int"},{"key":"2021042619271355800_gfaa373-B25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3747\/pdi.2017.00150","article-title":"Effects of oral paricalcitol and calcitriol treatment on peritoneal membrane characteristics of peritoneal dialysis patients - a pilot study","volume":"38","author":"Farhat","year":"2018","journal-title":"Perit Dial Int"},{"key":"2021042619271355800_gfaa373-B26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ki.2009.175","article-title":"Renoprotective effects of vitamin D analogs","volume":"78","author":"Li","year":"2010","journal-title":"Kidney Int"},{"key":"2021042619271355800_gfaa373-B27","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/1470320310391922","article-title":"25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians","volume":"12","author":"Vaidya","year":"2011","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"2021042619271355800_gfaa373-B28","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/HYPERTENSIONAHA.109.148619","article-title":"Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans","volume":"55","author":"Forman","year":"2010","journal-title":"Hypertension"},{"key":"2021042619271355800_gfaa373-B29","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1161\/CIRCOUTCOMES.112.967604","article-title":"Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies","volume":"5","author":"Wang","year":"2012","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"2021042619271355800_gfaa373-B30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000081023","article-title":"Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study","volume":"24","author":"Gonzalez","year":"2004","journal-title":"Am J Nephrol"},{"key":"2021042619271355800_gfaa373-B31","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/ki.2008.408","article-title":"Suppression of renin-angiotensin gene expression in the kidney by paricalcitol","volume":"74","author":"Freundlich","year":"2008","journal-title":"Kidney Int"},{"key":"2021042619271355800_gfaa373-B32","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/FJC.0000000000000208","article-title":"AT2 receptor activities and pathophysiological implications","volume":"65","author":"Matavelli","year":"2015","journal-title":"J Cardiovasc Pharmacol"},{"key":"2021042619271355800_gfaa373-B33","doi-asserted-by":"crossref","first-page":"e0148696","DOI":"10.1371\/journal.pone.0148696","article-title":"Angiotensin II type 2 receptor decreases transforming growth factor-beta type II receptor expression and function in human renal proximal tubule cells","volume":"11","author":"Guo","year":"2016","journal-title":"PLoS One"},{"key":"2021042619271355800_gfaa373-B34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrneph.2013.110","article-title":"Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis","volume":"9","author":"Brown","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"2021042619271355800_gfaa373-B35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/783538","article-title":"Paricalcitol inhibits aldosterone-induced proinflammatory factors by modulating epidermal growth factor receptor pathway in cultured tubular epithelial cells","volume":"2015","author":"Morgado-Pascual","year":"2015","journal-title":"Biomed Res Int"},{"key":"2021042619271355800_gfaa373-B36","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1681\/ASN.2010121251","article-title":"Cross talk between the renin-angiotensin-aldosterone system and vitamin D-FGF-23-klotho in chronic kidney disease","volume":"22","author":"de Borst","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"2021042619271355800_gfaa373-B37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.ajkd.2014.07.022","article-title":"Fibroblast growth factor 23 and the antiproteinuric response to dietary sodium restriction during renin-angiotensin-aldosterone system blockade","volume":"65","author":"Humalda","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"2021042619271355800_gfaa373-B38","doi-asserted-by":"crossref","first-page":"e86301","DOI":"10.1371\/journal.pone.0086301","article-title":"Reduced renal \u03b1-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism","volume":"9","author":"Sakan","year":"2014","journal-title":"PLoS One"},{"key":"2021042619271355800_gfaa373-B39","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/jamainternmed.2015.0237","article-title":"Effect of vitamin D supplementation on blood pressure: a systematic review and meta-analysis incorporating individual patient data","volume":"175","author":"Beveridge","year":"2015","journal-title":"JAMA Intern Med"},{"key":"2021042619271355800_gfaa373-B40","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm1275","article-title":"Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach","volume":"11","author":"Lautrette","year":"2005","journal-title":"Nat Med"},{"key":"2021042619271355800_gfaa373-B41","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1681\/ASN.2019111206","article-title":"TRAF3 modulation: novel mechanism for the anti-inflammatory effects of the vitamin D receptor agonist paricalcitol in renal disease","volume":"31","author":"Rayego-Mateos","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2021042619271355800_gfaa373-B42","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/sj.bjc.6602484","article-title":"SNAIL vs vitamin D receptor expression in colon cancer: therapeutics implications","volume":"92","author":"Larriba","year":"2005","journal-title":"Br J Cancer"},{"key":"2021042619271355800_gfaa373-B43","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1681\/ASN.2009080872","article-title":"Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system","volume":"21","author":"Zhang","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2021042619271355800_gfaa373-B44","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1681\/ASN.2007060666","article-title":"Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling","volume":"19","author":"Tan","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"2021042619271355800_gfaa373-B45","doi-asserted-by":"crossref","first-page":"e0181757","DOI":"10.1371\/journal.pone.0181757","article-title":"Treatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin","volume":"12","author":"Chung","year":"2017","journal-title":"PLoS One"},{"key":"2021042619271355800_gfaa373-B46","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/sj.ki.5002406","article-title":"Differential effects of vitamin D receptor activators on vascular calcification in uremic rats","volume":"72","author":"Mizobuchi","year":"2007","journal-title":"Kidney Int"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfaa373\/36197558\/gfaa373.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/36\/5\/793\/37400309\/gfaa373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ndt\/article-pdf\/36\/5\/793\/37400309\/gfaa373.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T23:07:23Z","timestamp":1619478443000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/36\/5\/793\/6070179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,1,8]]},"published-print":{"date-parts":[[2021,4,26]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfaa373","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,1,8]]}}}