{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:41:58Z","timestamp":1791546118502,"version":"4.3.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bioimpedance spectroscopy (BIS) has proven to be a promising non-invasive technique for fluid monitoring in haemodialysis (HD) patients. While current BIS-based monitoring of pre- and post-dialysis fluid status utilizes benchtop devices, designed for intramural use, advancements in micro-electronics have enabled the development of wearable bioimpedance systems. Wearable systems meanwhile can offer a similar frequency range for current injection as commercially available benchtop devices. This opens opportunities for unobtrusive longitudinal fluid status monitoring, including transcellular fluid shifts, with the ultimate goal of improving fluid management, thereby lowering mortality and improving quality of life for HD patients. Ultra-miniaturized wearable devices can also offer simultaneous acquisition of multiple other parameters, including haemodynamic parameters. Combination of wearable BIS and additional longitudinal multiparametric data may aid in the prevention of both haemodynamic instability as well as fluid overload. The opportunity to also acquire data during interdialytic periods using wearable devices likely will give novel pathophysiological insights and the development of smart (predicting) algorithms could contribute to personalizing dialysis schemes and ultimately to autonomous (nocturnal) home dialysis. This review provides an overview of current research regarding wearable bioimpedance, with special attention to applications in end-stage kidney disease patients. Furthermore, we present an outlook on the future use of wearable bioimpedance within dialysis practice.<\/jats:p>","DOI":"10.1093\/ndt\/gfab025","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T04:57:23Z","timestamp":1612414643000},"page":"2048-2054","source":"Crossref","is-referenced-by-count":8,"title":["On the potential of wearable bioimpedance for longitudinal fluid monitoring in end-stage kidney disease"],"prefix":"10.1093","volume":"37","author":[{"given":"Lucas","family":"Lindeboom","sequence":"first","affiliation":[{"name":"IMEC The Netherlands\/Holst Centre, Health Research , Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seulki","family":"Lee","sequence":"additional","affiliation":[{"name":"IMEC The Netherlands\/Holst Centre, Health Research , Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fokko","family":"Wieringa","sequence":"additional","affiliation":[{"name":"IMEC The Netherlands\/Holst Centre, Health Research , Eindhoven, The Netherlands"},{"name":"Department of Nephrology, University Medical Center Utrecht , Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemijn","family":"Groenendaal","sequence":"additional","affiliation":[{"name":"IMEC The Netherlands\/Holst Centre, Health Research , Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Basile","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Miulli General Hospital , Acquaviva delle Fonti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van der Sande","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center , Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Kooman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center , Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"2022102109180075500_gfab025-B1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1525-139X.2010.00782.x","article-title":"Recurrent circulatory stress: the dark side of dialysis","volume":"23","author":"McIntyre","year":"2010","journal-title":"Semin Dial"},{"key":"2022102109180075500_gfab025-B2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1159\/000500877","article-title":"The prevalence of intradialytic hypotension in patients on conventional hemodialysis: a systematic review with meta-analysis","volume":"49","author":"Kuipers","year":"2019","journal-title":"Am J Nephrol"},{"key":"2022102109180075500_gfab025-B3","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.kint.2016.12.008","article-title":"Impact of fluid status and inflammation and their interaction on survival: a study in an international hemodialysis patient cohort","volume":"91","author":"Dekker","year":"2017","journal-title":"Kidney Int"},{"key":"2022102109180075500_gfab025-B4","doi-asserted-by":"crossref","first-page":"686","DOI":"10.7150\/ijms.16372","article-title":"Overhydration negatively affects quality of life in peritoneal dialysis patients: evidence from a prospective observational study","volume":"13","author":"Yoon","year":"2016","journal-title":"Int J Med Sci"},{"key":"2022102109180075500_gfab025-B5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1681\/ASN.V102392","article-title":"Assessment of dry weight in hemodialysis an overview","volume":"10","author":"Jaeger","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"2022102109180075500_gfab025-B6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s40620-015-0189-x","article-title":"Physical methods for evaluating the nutrition status of hemodialysis patients","volume":"28","author":"Marcelli","year":"2015","journal-title":"J Nephrol"},{"key":"2022102109180075500_gfab025-B7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1085\/jgp.9.2.153","article-title":"The electric resistance and capacity of blood for frequencies between 800 and 4\u00bd million cycles","volume":"9","author":"Fricke","year":"1925","journal-title":"J Gen Physiol"},{"key":"2022102109180075500_gfab025-B8","first-page":"Abstract 333","article-title":"Monitoring volume changes in hemodialysis (HD) with bioimpedance spectroscopy (BIS)","volume":"4","author":"Bestoso","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"2022102109180075500_gfab025-B9","first-page":"20","article-title":"Multifrequency bioimpedance in assessment of dry weight in haemodialysis","volume":"11","author":"Katzarski","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"2022102109180075500_gfab025-B10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1063\/1.1750906","article-title":"Dispersion and absorption in dielectrics. I. Alternating current characteristics","volume":"9","author":"Cole","year":"1941","journal-title":"J Chem Phys"},{"key":"2022102109180075500_gfab025-B11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1101\/SQB.1940.008.01.013","article-title":"Permeability and impermeability of cell membranes for ions","volume":"8","author":"Cole","year":"1940","journal-title":"Cold Spring Harbor Sympos Quant Biol"},{"key":"2022102109180075500_gfab025-B12","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1152\/jappl.1997.82.5.1542","article-title":"Predicting body cell mass with bioimpedance by using theoretical methods: a technological review","volume":"82","author":"De Lorenzo","year":"1997","journal-title":"J Appl Physiol"},{"key":"2022102109180075500_gfab025-B13","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/ki.1994.416","article-title":"Bioimpedance analysis of total body water in hemodialysis patients","volume":"46","author":"Ho","year":"1994","journal-title":"Kidney Int"},{"key":"2022102109180075500_gfab025-B14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/MNH.0000000000000409","article-title":"Fluid status assessment in hemodialysis patients and the association with outcome: review of recent literature","volume":"27","author":"Dekker","year":"2018","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2022102109180075500_gfab025-B15","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1681\/ASN.2016121341","article-title":"Chronic fluid overload and mortality in ESRD","volume":"28","author":"Zoccali","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2022102109180075500_gfab025-B16","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1053\/j.ajkd.2012.12.017","article-title":"Effect of fluid management guided by bioimpedance spectroscopy on cardiovascular parameters in hemodialysis patients: a randomized controlled trial","volume":"61","author":"Hur","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"2022102109180075500_gfab025-B17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1053\/j.ajkd.2014.01.420","article-title":"Bioimpedance-guided fluid management in maintenance hemodialysis: a pilot randomized controlled trial","volume":"64","author":"Onofriescu","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"2022102109180075500_gfab025-B18","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2215\/CJN.06480619","article-title":"Bioimpedance guided fluid management in peritoneal dialysis: a randomized controlled trial","volume":"15","author":"Tian","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022102109180075500_gfab025-B19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/ckj\/sfz123","article-title":"Monitoring transcellular fluid shifts during episodes of intradialytic hypotension using bioimpedance spectroscopy","volume":"14","author":"Ismail","year":"2019","journal-title":"Clin Kidney J"},{"key":"2022102109180075500_gfab025-B20","volume-title":"Fostering Innovation in Fluid Management, KHI roadmap document (not indexed in PUBMED).","author":"Kidney Health Initiative (KHI)","year":"2019"},{"key":"2022102109180075500_gfab025-B21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1751-7133.2011.00271.x","article-title":"Monitoring changes in fluid status with a wireless multisensor monitor: results from the fluid removal during adherent renal monitoring (FARM) study","volume":"18","author":"Anand","year":"2012","journal-title":"Congest Heart Fail"},{"key":"2022102109180075500_gfab025-B22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12882-020-01922-6","article-title":"Towards personalized fluid monitoring in haemodialysis patients: thoracic bioimpedance signal shows strong correlation with fluid changes, a cohort study","volume":"21","author":"Schoutteten","year":"2020","journal-title":"BMC Nephrol"},{"key":"2022102109180075500_gfab025-B23","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2196\/cardio.6057","article-title":"Bioimpedance-based heart failure deterioration prediction using a prototype fluid accumulation vest-mobile phone dyad: an observational study","volume":"1","author":"Darling","year":"2017","journal-title":"JMIR Cardio"},{"key":"2022102109180075500_gfab025-B24","author":"Castro Miller","year":"2019"},{"key":"2022102109180075500_gfab025-B25","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1109\/TBCAS.2019.2945114","article-title":"A 769 muW batterypowered single-chip SoC with BLE for multi-modal vital sign monitoring health patches","volume":"13","author":"Song","year":"2019","journal-title":"IEEE Trans Biomed Circuits Syst"},{"key":"2022102109180075500_gfab025-B26","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1109\/JSSC.2014.2359962","article-title":"A 345 \u00b5W multi-sensor biomedical SoC with bio-impedance, 3-channel ECG, motion Artifact reduction, and integrated DSP","volume":"50","author":"Van Helleputte","year":"2015","journal-title":"IEEE J Solid State Circuits"},{"key":"2022102109180075500_gfab025-B27","author":"Lee","year":"2019"},{"key":"2022102109180075500_gfab025-B28","doi-asserted-by":"crossref","first-page":"e009175","DOI":"10.1161\/JAHA.118.009175","article-title":"Relationship between noninvasive assessment of lung fluid volume and invasively measured cardiac hemodynamics","volume":"7","author":"Uriel","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2022102109180075500_gfab025-B29","doi-asserted-by":"crossref","first-page":"e12141","DOI":"10.2196\/12141","article-title":"The added value of in-hospital tracking of the efficacy of decongestion therapy and prognostic value of a wearable thoracic impedance sensor in acutely decompensated heart failure with volume overload: prospective cohort study","volume":"4","author":"Smeets","year":"2020","journal-title":"JMIR Cardio"},{"key":"2022102109180075500_gfab025-B30","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00002480-199809000-00045","article-title":"Validation of changes in extracellular volume measured during hemodialysis using a segmental bioimpedance technique","volume":"44","author":"Zhu","year":"1998","journal-title":"ASAIO J"},{"key":"2022102109180075500_gfab025-B31","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000170154","article-title":"Validation study of thoracic fluid bioimpedance for assessing the haemodialysis-induced changes in total body fluids","volume":"12","author":"Graziani","year":"1994","journal-title":"Blood Purif"},{"key":"2022102109180075500_gfab025-B32","doi-asserted-by":"crossref","first-page":"S503","DOI":"10.1088\/0967-3334\/29\/6\/S42","article-title":"A method for the estimation of hydration state during hemodialysis using a calf bioimpedance technique","volume":"29","author":"Zhu","year":"2008","journal-title":"Physiol Meas"},{"key":"2022102109180075500_gfab025-B33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000368937","article-title":"Estimation of body composition and normal fluid status using a calf bioimpedance technique","volume":"39","author":"Zhu","year":"2015","journal-title":"Blood Purif"},{"key":"2022102109180075500_gfab025-B34","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ki.1997.150","article-title":"Effect of postural changes in the reliability of volume estimations from bioimpedance spectroscopy data","volume":"51","author":"Scharfetter","year":"1997","journal-title":"Kidney Int"},{"key":"2022102109180075500_gfab025-B35","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/mus.21362","article-title":"Electrical impedance myography: background, current state, and future directions","volume":"40","author":"Rutkove","year":"2009","journal-title":"Muscle Nerve"},{"key":"2022102109180075500_gfab025-B36","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12882-017-0554-1","article-title":"Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients","volume":"18","author":"Davies","year":"2017","journal-title":"BMC Nephrol"},{"key":"2022102109180075500_gfab025-B37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41581-020-0275-8","article-title":"Regulatory approaches to stimulate innovative renal replacement therapies","volume":"16","author":"Wieringa","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"2022102109180075500_gfab025-B38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s40620-014-0159-8","article-title":"Probing the dry weight by bioimpedance: the resistance stabilization test","volume":"28","author":"Basile","year":"2015","journal-title":"J Nephrol"},{"key":"2022102109180075500_gfab025-B39","doi-asserted-by":"crossref","first-page":"89487","DOI":"10.1109\/ACCESS.2019.2926841","article-title":"Wearable bioimpedance measurement for respiratory monitoring during inspiratory loading","volume":"7","author":"Blanco-Almazan","year":"2019","journal-title":"IEEE Access"},{"key":"2022102109180075500_gfab025-B40","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1749-6632.1970.tb17735.x","article-title":"Impedance cardiography as a noninvasive method of monitoring cardiac function and other parameters of the cardiovascular system","volume":"170","author":"Kubicek","year":"1970","journal-title":"Ann NY Acad Sci"},{"key":"2022102109180075500_gfab025-B41","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.3390\/s18082414","article-title":"Wearable health devices-vital sign monitoring, systems and technologies","volume":"18","author":"Dias","year":"2018","journal-title":"Sensors"},{"key":"2022102109180075500_gfab025-B42","doi-asserted-by":"crossref","first-page":"ii43","DOI":"10.1093\/ndt\/gfaa015","article-title":"Wearable health devices and personal area networks: can they improve outcome in haemodialysis patients?","volume":"35","author":"Kooman","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"2022102109180075500_gfab025-B43","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s00467-018-4015-2","article-title":"Artificial intelligence outperforms experienced nephrologists to assess dry weight in pediatric patients on chronic hemodialysis","volume":"33","author":"Niel","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"2022102109180075500_gfab025-B44","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/jamia\/ocy073","article-title":"Primary care provider adherence to an alert for intensification of diabetes blood presure medications before and after the addition of a \"chart closure\u201d hard stop","volume":"25","author":"Ramirez","year":"2018","journal-title":"J Am Med Inform Assoc"},{"key":"2022102109180075500_gfab025-B45","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1109\/JBHI.2016.2524646","article-title":"Motion artifact suppression in impedance pneumography signal for portable monitoring of respiration: an adaptive approach","volume":"21","author":"Ansari","year":"2017","journal-title":"IEEE J Biomed Health Inform"},{"key":"2022102109180075500_gfab025-B46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3758\/BF03195525","article-title":"Large-scale ensemble averaging of ambulatory impedance cardiograms","volume":"35","author":"Riese","year":"2003","journal-title":"Behav Res Methods Instrument Comput"},{"key":"2022102109180075500_gfab025-B47","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2217\/pme-2018-0044","article-title":"Wearables and the medical revolution","volume":"15","author":"Dunn","year":"2018","journal-title":"Pers Med"},{"key":"2022102109180075500_gfab025-B48","first-page":"1","article-title":"Patients' views of wearable devices and AI in healthcare: findings from the ComPaRe e-cohort","volume":"14","author":"Tran","year":"2019","journal-title":"NPJ Digit Med"},{"key":"2022102109180075500_gfab025-B49","doi-asserted-by":"crossref","first-page":"3G\u201310G","DOI":"10.1016\/j.amjcard.2007.02.009","article-title":"Fundamentals of intrathoracic impedance monitoring in heart failure","volume":"99","author":"Wang","year":"2007","journal-title":"Am J Cardiol"},{"key":"2022102109180075500_gfab025-B50","author":"Lee","year":"2019"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfab025\/36719205\/gfab025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/37\/11\/2048\/46585868\/gfab025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/37\/11\/2048\/46585868\/gfab025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T09:22:11Z","timestamp":1666344131000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/37\/11\/2048\/6129268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,2,5]]},"published-print":{"date-parts":[[2022,10,19]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfab025","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,11]]},"published":{"date-parts":[[2021,2,5]]}}}