{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:53Z","timestamp":1790068733822,"version":"4.0.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Plan for Clinical Research","award":["NCT02112136"],"award-info":[{"award-number":["NCT02112136"]}]},{"name":"French Association for Information and Research on Genetic Kidney Diseases"},{"name":"Otsuka Pharmaceuticals Industry"},{"name":"National Research Agency","award":["JCJC 2019 GENOVAS-PKD"],"award-info":[{"award-number":["JCJC 2019 GENOVAS-PKD"]}]},{"name":"National Research Agency","award":["R19145NN"],"award-info":[{"award-number":["R19145NN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,19]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is associated with an increased risk for developing intracranial aneurysms (IAs). We aimed to evaluate the frequency of diagnosis of IAs in the cross-sectional, population-based, Genkyst cohort, to describe ADPKD-associated IAs and to analyse the risk factors associated with the occurrence of IAs in ADPKD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross-sectional study was performed in 26 nephrology centres from the western part of France. All patients underwent genetic testing for PKD1\/PKD2 and other cystogenes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 2449 Genkyst participants, 114 (4.65%) had a previous diagnosis of ruptured or unruptured IAs at inclusion, and \u223c47% of them had a positive familial history for IAs. Most aneurysms were small and saccular and located in the anterior circulation; 26.3% of the patients had multiple IAs. The cumulative probabilities of a previous diagnosis of IAs were 3.9%, 6.2% and 8.1% at 50, 60 and 70 years, respectively. While this risk appeared to be similar in male and female individuals &amp;lt;50\u00a0years, after that age, the risk continued to increase more markedly in female patients, reaching 10.8%\u00a0versus 5.4% at 70 years. The diagnosis rate of IAs was &amp;gt;2-fold higher in PKD1 compared with PKD2, with no influence of PKD1 mutation type or location. In multivariate analysis, female sex, hypertension &amp;lt;35\u00a0years, smoking and PKD1 genotype were associated with an increased risk for diagnosis of IAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study presents epidemiological data reflecting real-life clinical practice. The increased risk for IAs in postmenopausal women suggests a possible protective role of oestrogen.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfac027","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T20:12:24Z","timestamp":1643659944000},"page":"2223-2233","source":"Crossref","is-referenced-by-count":26,"title":["Diagnosis and risk factors for intracranial aneurysms in autosomal polycystic kidney disease: a cross-sectional study from the Genkyst cohort"],"prefix":"10.1093","volume":"37","author":[{"given":"Siriane","family":"Lef\u00e8vre","sequence":"first","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00e9modialyse et Transplantation r\u00e9nale, CHRU Brest , Brest, France"},{"name":"Univ Brest, Inserm , UMR 1078, GGB, Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Audr\u00e9zet","sequence":"additional","affiliation":[{"name":"Univ Brest, Inserm , UMR 1078, GGB, 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