{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:46:23Z","timestamp":1791639983393,"version":"4.3.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":289,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Reference Network for Rare Kidney Diseases"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["ERN-2016-Framework"],"award-info":[{"award-number":["ERN-2016-Framework"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["2017\u20132021"],"award-info":[{"award-number":["2017\u20132021"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Small cohort studies have reported high parathyroid hormone (PTH) levels in patients with Bartter syndrome and lower serum phosphate levels have anecdotally been reported in patients with Gitelman syndrome. In this cross-sectional study, we assessed PTH and phosphate homeostasis in a large cohort of patients with salt-losing tubulopathies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical and laboratory data of 589 patients with Bartter and Gitelman syndrome were provided by members of the European Rare Kidney Diseases Reference Network (ERKNet) and the European Society for Paediatric Nephrology (ESPN).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 285 patients with Bartter syndrome and 304 patients with Gitelman syndrome were included for analysis. Patients with Bartter syndrome type I and II had the highest median PTH level (7.5\u00a0pmol\/L) and 56% had hyperparathyroidism (PTH\u00a0&amp;gt;7.0\u00a0pmol\/L).\u00a0Serum calcium was slightly lower in Bartter syndrome type I and II patients with hyperparathyroidism (2.42\u00a0versus 2.49\u00a0mmol\/L; P\u00a0=\u00a0.038) compared to those with normal PTH levels and correlated inversely with PTH (rs \u22120.253; P\u00a0=\u00a0.009). Serum phosphate and urinary phosphate excretion did not correlate with PTH. Overall, 22% of patients had low serum phosphate levels (phosphate\u2014standard deviation score &amp;lt; \u22122), with the highest prevalence in patients with Bartter syndrome type III (32%). Serum phosphate correlated with tubular maximum reabsorption of phosphate\/glomerular filtration rate (TmP\/GFR) (rs 0.699; P &amp;lt;\u00a0.001), suggesting renal phosphate wasting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Hyperparathyroidism is frequent in patients with Bartter syndrome type I and II. Low serum phosphate is observed in a significant number of patients with Bartter and Gitelman syndrome and appears associated with renal phosphate wasting.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfac029","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T04:14:33Z","timestamp":1643948073000},"page":"2474-2486","source":"Crossref","is-referenced-by-count":17,"title":["Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome: an international cross-sectional study"],"prefix":"10.1093","volume":"37","author":[{"given":"Maartje F A","family":"Verploegen","sequence":"first","affiliation":[{"name":"Department of Nephrology, Radboud University Medical Center , Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-0680","authenticated-orcid":false,"given":"Rosa","family":"Vargas-Poussou","sequence":"additional","affiliation":[{"name":"Department of Genetics, Centre de R\u00e9f\u00e9rences MARHEA, H\u00f4pital Europ\u00e9en Georges Pompidou Assistance Publique H\u00f4pitaux de Paris , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, University College London , London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harika","family":"Alpay","sequence":"additional","affiliation":[{"name":"Division of Paediatric Nephrology, Faculty of Medicine, Marmara University , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3090-1662","authenticated-orcid":false,"given":"Atefeh","family":"Amouzegar","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences , Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Ariceta","sequence":"additional","affiliation":[{"name":"Paediatric Nephrology Department, University Hospital Vall d'Hebron , Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahriye","family":"Atmis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, Cukurova University Faculty of Medicine , Adana, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0578-2529","authenticated-orcid":false,"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, Rheumatology and Dermatology, Reference Centre for Rare Renal Diseases, Reference Centre for Rare Diseases of Calcium and Phosphate Metabolism. University Children's Hospital, Lyon , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"B\u00e1r\u00e1ny","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital , Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Physiology, H\u00f4pital Europ\u00e9en Georges Pompidou Assistance Publique H\u00f4pitaux de Paris , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut Selda","family":"Bayrakci","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, Ankara City Hospital, \u00dcniversiteler Mahallesi Bilkent Caddesi , \u00c7ankaya\/Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrica","family":"Belge","sequence":"additional","affiliation":[{"name":"Center for Human Genetics, Institute of Pathology and Genetics , Gosselies, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Besouw","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, University of Groningen, University Medical Centre Groningen , Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-0586","authenticated-orcid":false,"given":"Anne","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Clinical Research Centre 1418, Centre de R\u00e9f\u00e9rences MARHEA, H\u00f4pital Europ\u00e9en Georges Pompidou Assistance Publique H\u00f4pitaux de Paris , Paris, France"},{"name":"Centre de Recherche des Cordeliers, INSERM, Sorbonne Universit\u00e9, Universit\u00e9 de Paris , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend","family":"B\u00f6kenkamp","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam , Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Boyer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, Necker Hospital, APHP, MARHEA, Imagine Institute, Paris University , Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-1096","authenticated-orcid":false,"given":"Kathrin","family":"Burgmaier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Hospital of Cologne, Children's and Adolescents' Hospital, Paediatric Nephrology, University of Cologne , Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo A","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Nephrology, Dialysis, Transplantation, University of Padova , Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Decramer","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology. 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