{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:23:38Z","timestamp":1780057418390,"version":"3.54.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/25359-0"],"award-info":[{"award-number":["2016\/25359-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["309045\/2018-5"],"award-info":[{"award-number":["309045\/2018-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305556\/2017-7"],"award-info":[{"award-number":["305556\/2017-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o Oswaldo Ramos\u2014Hospital do Rim"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low areal bone mineral density (BMD), increased fracture risk and altered bone remodeling have been described among stone formers (SFs), but the magnitude of these findings differs by age, sex, menopausal status and urinary calcium (uCa). This study aimed to investigate volumetric BMD (vBMD), bone microarchitecture and biomechanical properties by high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA) in young SFs, irrespective of calciuria, further distinguishing trabecular from cortical compartments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HR-pQCT\/FEA was performed at the distal tibia (DT) and distal radius (DR) in 106 SFs (57 males and 49 premenopausal females; median age 37 years) and compared with 106 non-SFs (NSFs) retrieved from an existing database, matched for age, sex and body mass index (BMI). Biochemical\/hormonal serum and urinary parameters were obtained from SFs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SFs exhibited significantly lower trabecular number (TbN) and higher trabecular separation (TbSp) than NSFs at both anatomical sites and lower cortical porosity in the DR. In a subgroup analysis separated by sex, female SFs presented significantly lower TbvBMD, relative bone volume fraction (BV\/TV) and TbN and higher TbSp than NSFs at both sites, while male SFs showed significantly lower stiffness and failure load. Multivariate analysis showed TbN to be independently associated with sex and BMI at both sites and with uCa at the DR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings suggest that bone disease represents an early event among SFs, associated at least in part with calcium excretion and mainly characterized by trabecular bone microarchitecture impairment, especially among women, but with reduced bone strength parameters in men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfac128","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T23:12:09Z","timestamp":1646867529000},"page":"425-434","source":"Crossref","is-referenced-by-count":9,"title":["Bone density, microarchitecture and estimated strength in stone formers: a cross-sectional HR-pQCT study"],"prefix":"10.1093","volume":"38","author":[{"given":"Priscila Ligeiro Gon\u00e7alves","family":"Esper","sequence":"first","affiliation":[{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Guedes","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Nutrition Post Graduation Program, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita Lima","family":"Melo","sequence":"additional","affiliation":[{"name":"Nutrition Post Graduation Program, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene Subtil","family":"Ormanji","sequence":"additional","affiliation":[{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M","family":"Campos","sequence":"additional","affiliation":[{"name":"Heart Institute, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , ; Instituto Prevent Senior","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackeline Couto","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria de Falco","family":"Caparbo","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aluizio Barbosa","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria Rodrigues","family":"Pereira","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-5877","authenticated-orcid":false,"given":"Ita Pfeferman","family":"Heilberg","sequence":"additional","affiliation":[{"name":"Nephrology Division, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo ,","place":["Brazil"]},{"name":"Nutrition Post Graduation Program, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo 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