{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:45:54Z","timestamp":1769582754175,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100020141","name":"Akebia Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK120524-02"],"award-info":[{"award-number":["T32 DK120524-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR065971"],"award-info":[{"award-number":["AR065971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32DK122731"],"award-info":[{"award-number":["F32DK122731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK110871"],"award-info":[{"award-number":["RO1DK110871"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AR072581"],"award-info":[{"award-number":["P30AR072581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002529"],"award-info":[{"award-number":["UL1TR002529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["I01 BX001471"],"award-info":[{"award-number":["I01 BX001471"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["BX003025"],"award-info":[{"award-number":["BX003025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK110871"],"award-info":[{"award-number":["RO1DK110871"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK119266"],"award-info":[{"award-number":["DK119266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veteran's Administration","award":["I01BX001471"],"award-info":[{"award-number":["I01BX001471"]}]},{"DOI":"10.13039\/100010249","name":"Indiana University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Anemia and chronic kidney disease\u2013mineral and bone disorder (CKD-MBD) are common and begin early in CKD. Limited studies have concurrently compared the effects of ferric citrate (FC) versus intravenous (IV) iron on CKD-MBD and iron homeostasis in moderate CKD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We tested the effects of 10 weeks of 2% FC versus IV iron sucrose in rats with moderate CKD (Cy\/+ male rat) and untreated normal (NL) littermates. Outcomes included a comprehensive assessment of CKD-MBD, iron homeostasis and oxidative stress.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CKD rats had azotemia, elevated phosphorus, parathyroid hormone and fibroblast growth factor-23 (FGF23). Compared with untreated CKD rats, treatment with FC led to lower plasma phosphorus, intact FGF23 and a trend (P\u00a0=\u00a00.07) toward lower C-terminal FGF23. FC and IV iron equally reduced aorta and heart calcifications to levels similar to NL animals. Compared with NL animals, CKD animals had higher bone turnover, lower trabecular volume and no difference in mineralization; these were unaffected by either iron treatment. Rats treated with IV iron had cortical and bone mechanical properties similar to NL animals. FC increased the transferrin saturation rate compared with untreated CKD and NL rats. Neither iron treatment increased oxidative stress above that of untreated CKD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Oral FC improved phosphorus homeostasis, some iron-related parameters and the production and cleavage of FGF23. The intermittent effect of low-dose IV iron sucrose on cardiovascular calcification and bone should be further explored in moderate\u2013advanced CKD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfac162","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T19:26:26Z","timestamp":1651001186000},"page":"1857-1867","source":"Crossref","is-referenced-by-count":9,"title":["Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD"],"prefix":"10.1093","volume":"37","author":[{"given":"Annabel","family":"Biruete","sequence":"first","affiliation":[{"name":"Division of Nephrology, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"Department of Nutrition and Dietetics, Indiana University-Purdue University Indianapolis , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne E","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal X","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Indiana University School of Medicine , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Swallow","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis","family":"Vrabec","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"College of Osteopathic Medicine, Marian University , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica L","family":"Clinkenbeard","sequence":"additional","affiliation":[{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J","family":"Stacy","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shruthi","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Indiana University School of Medicine , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalisha","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Indiana University School of Medicine , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith G","family":"Avin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"Department of Physical Therapy, Indiana University School of Health and Human Sciences, Indiana University , Indianapolis , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"Roudebush Veterans Affairs Medical Center , Indianapolis, IN , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon M","family":"Moe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine , Indianapolis , IN, USA"},{"name":"Roudebush Veterans Affairs Medical Center , Indianapolis, IN , IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"2022092208185405700_bib1","first-page":"709","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume-title":"Lancet.","author":"GBD Chronic Kidney Disease Collaboration","year":"2020"},{"key":"2022092208185405700_bib2","doi-asserted-by":"crossref","first-page":"e84943","DOI":"10.1371\/journal.pone.0084943","article-title":"Prevalence of anemia in chronic kidney disease in the United States","volume":"9","author":"Stauffer","year":"2014","journal-title":"PLoS One"},{"key":"2022092208185405700_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.ackd.2006.10.005","article-title":"Chronic kidney disease-mineral-bone disorder: a new paradigm","volume":"14","author":"Moe","year":"2007","journal-title":"Adv Chronic Kidney Dis"},{"key":"2022092208185405700_bib4","doi-asserted-by":"crossref","first-page":"300060519895844","DOI":"10.1177\/0300060519895844","article-title":"Effect of CKD-MBD phenotype on health-related quality of life in patients receiving maintenance hemodialysis: a cross-sectional study","volume":"48","author":"Luo","year":"2020","journal-title":"J Int Med Res"},{"key":"2022092208185405700_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/13696998.2019.1588738","article-title":"Economic and quality of life burden of anemia on patients with CKD on dialysis: a systematic review","volume":"22","author":"Spinowitz","year":"2019","journal-title":"J Med Econ"},{"key":"2022092208185405700_bib6","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.2215\/CJN.04260413","article-title":"CKD-mineral and bone disorder and risk of death and cardiovascular hospitalization in patients on hemodialysis","volume":"8","author":"Block","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022092208185405700_bib7","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1681\/ASN.2005020183","article-title":"Anemia as a predictor of cardiovascular events in patients with elevated serum creatinine","volume":"17","author":"Walker","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib8","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/ki.2012.270","article-title":"Summary of the KDIGO guideline on anemia and comment: reading between the (guide)line(s)","volume":"82","author":"Drueke","year":"2012","journal-title":"Kidney Int"},{"key":"2022092208185405700_bib9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s40265-019-01125-w","article-title":"Mechanism of action and clinical attributes of Auryxia\u00ae (ferric citrate)","volume":"79","author":"Ganz","year":"2019","journal-title":"Drugs"},{"key":"2022092208185405700_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1124\/jpet.118.249961","article-title":"Phosphate binder, ferric citrate, attenuates anemia, renal dysfunction, oxidative stress, inflammation, and fibrosis in 5\/6 nephrectomized CKD rats","volume":"367","author":"Jing","year":"2018","journal-title":"J Pharmacol Exp Ther"},{"key":"2022092208185405700_bib11","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.kint.2019.07.026","article-title":"Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease","volume":"96","author":"Francis","year":"2019","journal-title":"Kidney Int"},{"key":"2022092208185405700_bib12","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1053\/j.ajkd.2014.10.014","article-title":"A 12-week, double-blind, placebo-controlled trial of ferric citrate for the treatment of iron deficiency anemia and reduction of serum phosphate in patients with CKD Stages 3\u20135","volume":"65","author":"Block","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"2022092208185405700_bib13","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1681\/ASN.2018101016","article-title":"A pilot randomized trial of ferric citrate coordination complex for the treatment of advanced CKD","volume":"30","author":"Block","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib14","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1681\/ASN.2016101053","article-title":"Effects of ferric citrate in patients with nondialysis-dependent CKD and iron deficiency anemia","volume":"28","author":"Fishbane","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2215\/CJN.05170513","article-title":"Ferric citrate hydrate for the treatment of hyperphosphatemia in nondialysis-dependent CKD","volume":"9","author":"Yokoyama","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022092208185405700_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1053\/j.ajkd.2015.03.013","article-title":"The phosphate binder ferric citrate and mineral metabolism and inflammatory markers in maintenance dialysis patients: results from prespecified analyses of a randomized clinical trial","volume":"66","author":"Van Buren","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"2022092208185405700_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1053\/j.jrn.2014.03.006","article-title":"Long-term safety and efficacy of a novel iron-containing phosphate binder, JTT-751, in patients receiving hemodialysis","volume":"24","author":"Yokoyama","year":"2014","journal-title":"J Ren Nutr"},{"key":"2022092208185405700_bib18","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1681\/ASN.2014080842","article-title":"Ferric citrate reduces intravenous iron and erythropoiesis-stimulating agent use in ESRD","volume":"26","author":"Umanath","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib19","doi-asserted-by":"crossref","first-page":"G397","DOI":"10.1152\/ajpgi.00348.2013","article-title":"Mechanistic and regulatory aspects of intestinal iron absorption","volume":"307","author":"Gulec","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2022092208185405700_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1681\/ASN.2014020212","article-title":"Ferric citrate controls phosphorus and delivers iron in patients on dialysis","volume":"26","author":"Lewis","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib21","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/sj.ki.5000164","article-title":"Proinflammatory effects of iron sucrose in chronic kidney disease","volume":"69","author":"Agarwal","year":"2006","journal-title":"Kidney Int"},{"key":"2022092208185405700_bib22","doi-asserted-by":"crossref","first-page":"e0157063","DOI":"10.1371\/journal.pone.0157063","article-title":"Hepcidin response to iron therapy in patients with non-dialysis dependent CKD: an analysis of the FIND-CKD Trial","volume":"11","author":"Gaillard","year":"2016","journal-title":"PLoS One"},{"key":"2022092208185405700_bib23","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1681\/ASN.2019020213","article-title":"Iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and treatment","volume":"31","author":"Batchelor","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib24","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.jrn.2017.12.009","article-title":"Oral versus intravenous iron supplementation for the treatment of iron deficiency anemia in patients on maintenance hemodialysis-effect on fibroblast growth factor-23 metabolism","volume":"28","author":"Fukao","year":"2018","journal-title":"J Ren Nutr"},{"key":"2022092208185405700_bib25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ki.2008.456","article-title":"A rat model of chronic kidney disease-mineral bone disorder","volume":"75","author":"Moe","year":"2009","journal-title":"Kidney Int"},{"key":"2022092208185405700_bib26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ki.2015.122","article-title":"The SAM domain of ANKS6 has different interacting partners and mutations can induce different cystic phenotypes","volume":"88","author":"Bakey","year":"2015","journal-title":"Kidney Int"},{"key":"2022092208185405700_bib27","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ng.2681","article-title":"ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3","volume":"45","author":"Hoff","year":"2013","journal-title":"Nat Genet"},{"key":"2022092208185405700_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0272-6386(97)90039-1","article-title":"Gender and the effect of gonadal hormones on the progression of inherited polycystic kidney disease in rats","volume":"29","author":"Cowley","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"2022092208185405700_bib29","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1038\/s41598-019-44415-9","article-title":"Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy\/+ rats","volume":"9","author":"Vorland","year":"2019","journal-title":"Sci Rep"},{"key":"2022092208185405700_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/jbmr.2372","article-title":"Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy","volume":"30","author":"Moe","year":"2015","journal-title":"J Bone Miner Res"},{"key":"2022092208185405700_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.trsl.2006.04.008","article-title":"Iron sucrose induced morphological and functional changes in the rat kidney","volume":"148","author":"Breborowicz","year":"2006","journal-title":"Transl Res"},{"key":"2022092208185405700_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000347031","article-title":"Transglutaminase 2 accelerates vascular calcification in chronic kidney disease","volume":"37","author":"Chen","year":"2013","journal-title":"Am J Nephrol"},{"key":"2022092208185405700_bib33","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res."},{"key":"2022092208185405700_bib34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"key":"2022092208185405700_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2105-7-123","article-title":"Detecting outliers when fitting data with nonlinear regression \u2013 a new method based on robust nonlinear regression and the false discovery rate","volume":"7","author":"Motulsky","year":"2006","journal-title":"BMC Bioinf"},{"key":"2022092208185405700_bib36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bone.2019.05.002","article-title":"Time course of rapid bone loss and cortical porosity formation observed by longitudinal \u00b5CT in a rat model of CKD","volume":"125","author":"McNerny","year":"2019","journal-title":"Bone"},{"key":"2022092208185405700_bib37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/01.mnh.0000447020.74593.6f","article-title":"Coupling fibroblast growth factor 23 production and cleavage: iron deficiency, rickets, and kidney disease","volume":"23","author":"Wolf","year":"2014","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2022092208185405700_bib38","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1681\/ASN.2013121343","article-title":"Pathogenesis of arrhythmias in a model of CKD","volume":"25","author":"Hsueh","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib39","doi-asserted-by":"crossref","first-page":"e0159411","DOI":"10.1371\/journal.pone.0159411","article-title":"Skeletal muscle regeneration and oxidative stress are altered in chronic kidney disease","volume":"11","author":"Avin","year":"2016","journal-title":"PLoS One"},{"key":"2022092208185405700_bib40","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1681\/ASN.2019040349","article-title":"Voluntary wheel running has beneficial effects in a rat model of CKD-mineral bone disorder (CKD-MBD)","volume":"30","author":"Avin","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib41","first-page":"19","article-title":"Effects of treadmill running in a rat model of chronic kidney disease","volume":"16","author":"Organ","year":"2018","journal-title":"Biochem Biophys Rep"},{"key":"2022092208185405700_bib42","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.bbadis.2008.10.008","article-title":"Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis","volume":"1792","author":"Chefetz","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2022092208185405700_bib43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbadis.2008.09.016","article-title":"GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity","volume":"1792","author":"Chefetz","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"2022092208185405700_bib44","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/ndt\/gfy318","article-title":"Effect of ferric citrate on serum phosphate and fibroblast growth factor 23 among patients with nondialysis-dependent chronic kidney disease: path analyses","volume":"34","author":"Block","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"2022092208185405700_bib45","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s11914-015-0293-9","article-title":"Pathophysiology of vascular calcification","volume":"13","author":"Chen","year":"2015","journal-title":"Curr Osteoporos Rep"},{"key":"2022092208185405700_bib46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1681\/ASN.2007080854","article-title":"Mechanisms of vascular calcification in chronic kidney disease","volume":"19","author":"Moe","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib47","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.3390\/ijms20235925","article-title":"Therapeutic effect of iron citrate in blocking calcium deposition in high Pi-calcified VSMC: role of autophagy and apoptosis","volume":"20","author":"Ciceri","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2022092208185405700_bib48","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000348805","article-title":"Ferric citrate hydrate, a new phosphate binder, prevents the complications of secondary hyperparathyroidism and vascular calcification","volume":"37","author":"Iida","year":"2013","journal-title":"Am J Nephrol"},{"key":"2022092208185405700_bib49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MNH.0000000000000329","article-title":"Iron-induced hypophosphatemia: an emerging complication","volume":"26","author":"Zoller","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"2022092208185405700_bib50","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.tmrv.2020.07.002","article-title":"Comparative risk of hypophosphatemia following the administration of intravenous iron formulations: a network meta-analysis","volume":"34","author":"Bellos","year":"2020","journal-title":"Transfus Med Rev"},{"key":"2022092208185405700_bib51","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2147\/TCRM.S243462","article-title":"Hypophosphatemia associated with intravenous iron therapies for iron deficiency anemia: a systematic literature review","volume":"16","author":"Glaspy","year":"2020","journal-title":"Ther Clin Risk Manag"},{"key":"2022092208185405700_bib52","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/jbmr.485","article-title":"The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat","volume":"26","author":"Moe","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2022092208185405700_bib53","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.3390\/nu7042324","article-title":"Chronic iron deficiency as an emerging risk factor for osteoporosis: a hypothesis","volume":"7","author":"Toxqui","year":"2015","journal-title":"Nutrients"},{"key":"2022092208185405700_bib54","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jsb.2013.04.009","article-title":"Of mice, rats and men: trabecular bone architecture in mammals scales to body mass with negative allometry","volume":"183","author":"Barak","year":"2013","journal-title":"J Struct Biol"},{"key":"2022092208185405700_bib55","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1681\/ASN.2011111078","article-title":"Mechanisms of anemia in CKD","volume":"23","author":"Babitt","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"2022092208185405700_bib56","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.3945\/jn.114.197939","article-title":"Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats","volume":"144","author":"Cao","year":"2014","journal-title":"J Nutr"},{"key":"2022092208185405700_bib57","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/ndt\/gfaa053","article-title":"Route of intestinal absorption and tissue distribution of iron contained in the novel phosphate binder ferric citrate","volume":"35","author":"Vaziri","year":"2020","journal-title":"Nephrol Dial Transplant"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfac162\/44109400\/gfac162.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/37\/10\/1857\/45971996\/gfac162.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/37\/10\/1857\/45971996\/gfac162.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T09:14:30Z","timestamp":1663838070000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/37\/10\/1857\/6575572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,4,28]]},"published-print":{"date-parts":[[2022,9,22]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfac162","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10]]},"published":{"date-parts":[[2022,4,28]]}}}