{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:42:23Z","timestamp":1778931743567,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070737"],"award-info":[{"award-number":["82070737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021JJ30940"],"award-info":[{"award-number":["2021JJ30940"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,23]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute kidney injury (AKI) is a public health problem with no specific therapies in the clinic and the underlying pathogenesis of AKI remains obscure. Bombesin receptor-activated protein (BRAP, C6ORF89 protein) was initially discovered as a ligand for a previously orphan G-protein-coupled receptor bombesin-like receptor-3. At present, accepted biological effects of BRAP include cell cycle progression, wound repair and the activation of histone deacetylases. However, its role in kidney disease is unknown. In this study we have investigated the role of BRAP and underlying mechanisms involved in cisplatin (CP)-induced AKI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Here we used Bc004004 (homologous of C6ORF89 in mice) knockout mice and HK2 cells to investigate the effect of BRAP on AKI in vitro and in vivo. We analyzed ChIP-Seq and RNA-Seq data to search for the upstream regulators of BRAP and downstream mediators of BRAP action in AKI. Immunostaining, real-time polymerase chain reaction (PCR), co-immunoprecipitation, a dual-luciferase reporter assay and ChIP-PCR assay were applied to reveal the upstream and downstream regulation mechanism of BRAP during cisplatin-induced AKI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>BRAP was downregulated in mice and human kidneys with AKI. Global Bc004004 deletion alleviated tubular cell apoptosis and necroptosis in CP-induced AKI mice, whereas local overexpression of BRAP in kidneys aggravated them. Pan-caspase inhibitor Z-VAD pretreatment attenuated CP-induced blood creatinine increase and kidney injury in wild-type mice but not in BRAP\u2009-\/-\u2009mice. The activation of mixed lineage kinase like-domain was magnified by Z-VAD in CP-treated mice, especially in BRAP\u2009-\/-\u2009mice. The cytoprotective effect of Z-VAD was more substantial than necrostatin-1 (Nec-1, an inhibitor of necroptosis) in CP-treated human kidney proximal tubular epithelial (HK2) cells. Furthermore, Nec-1 pretreatment reduced the CP-induced cell death in BRAP overexpression HK2 cells but did not work in cells with normal BRAP levels. We determined that CP treatment activated the nuclear factor-\u03baB subunit P65 and inhibition of P65 increased the messenger RNA (mRNA) levels of BRAP in HK2 cells. The chromatin immunoprecipitation assay and dual-luciferase reporter gene assay verified P65 binding to the C6ORF89 promoter and reduced its mRNA expression upon CP treatment. Next we found that sirtuin 2 (SIRT2) was downregulated in CP-induced AKI and BRAP levels directly impacted the protein levels of SIRT2. Our findings further confirmed that BRAP regulates the SIRT2 protein levels by affecting SIRT2\u2019s interactions with E3 ubiquitin ligase HRD1 and subsequent proteasomal degradation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results demonstrated that BRAP played an important role in tubular cell apoptosis and necroptosis during CP-induced AKI. Safe and efficient BRAP inhibitors might be effective therapeutic options for AKI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfac164","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T19:25:32Z","timestamp":1651173932000},"page":"2366-2385","source":"Crossref","is-referenced-by-count":6,"title":["Bombesin receptor-activated protein exacerbates cisplatin-induced AKI by regulating the degradation of SIRT2"],"prefix":"10.1093","volume":"37","author":[{"given":"Liang","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangpin","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Xiangya School of Medicine, Central South University , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center , Augusta, GA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6040-5323","authenticated-orcid":false,"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Second Xiangya Hospital of Central South University , Changsha, Hunan , China"},{"name":"Hunan Key Laboratory of Kidney Disease and Blood Purification , Changsha, Hunan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"2022112304495807900_bib1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41581-018-0103-6","article-title":"Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications","volume":"15","author":"Guo","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"2022112304495807900_bib2","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.2215\/CJN.15611219","article-title":"AKI!Now initiative: recommendations for awareness, recognition, and management of AKI","volume":"15","author":"Liu","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"2022112304495807900_bib3","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1681\/ASN.2014080741","article-title":"A role for tubular necroptosis in cisplatin-induced AKI","volume":"26","author":"Xu","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib4","doi-asserted-by":"crossref","first-page":"12024","DOI":"10.1073\/pnas.1305538110","article-title":"Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury","volume":"110","author":"Linkermann","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112304495807900_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"2022112304495807900_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41419-018-0394-3","article-title":"Phenytoin inhibits necroptosis","volume":"9","author":"von M\u00e4ssenhausen","year":"2018","journal-title":"Cell Death Dis"},{"key":"2022112304495807900_bib7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ki.2010.317","article-title":"Renal tubular fas ligand mediates fratricide in cisplatin-induced acute kidney failure","volume":"79","author":"Linkermann","year":"2011","journal-title":"Kidney Int"},{"key":"2022112304495807900_bib8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1172\/JCI6974","article-title":"Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation","volume":"104","author":"Daemen","year":"1999","journal-title":"J Clin Invest"},{"key":"2022112304495807900_bib9","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1097\/01.ASN.0000145530.73247.F5","article-title":"Acute renal failure in endotoxemia is dependent on caspase activation","volume":"15","author":"Guo","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib10","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41419-020-03267-2","article-title":"PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells","volume":"11","author":"Zhu","year":"2020","journal-title":"Cell Death Dis"},{"key":"2022112304495807900_bib11","doi-asserted-by":"crossref","first-page":"e23072","DOI":"10.1371\/journal.pone.0023072","article-title":"Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"2022112304495807900_bib12","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/jcp.24355","article-title":"C6orf89 encodes three distinct HDAC enhancers that function in the nucleolus, the golgi and the midbody","volume":"228","author":"Lalioti","year":"2013","journal-title":"J Cell Physiol"},{"key":"2022112304495807900_bib13","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/jcb.25406","article-title":"Bombesin receptor-activated protein (BRAP) modulates NF-\u03baB activation in bronchial epithelial cells by enhancing HDAC activity","volume":"117","author":"Liu","year":"2016","journal-title":"J Cell Biochem"},{"key":"2022112304495807900_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.yexcr.2017.05.002","article-title":"Bombesin receptor-activated protein regulates neutrophil elastase-induced mucin5AC hypersecretion in human bronchial epithelial cells","volume":"357","author":"Xu","year":"2017","journal-title":"Exp Cell Res"},{"key":"2022112304495807900_bib15","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1681\/ASN.2017111218","article-title":"Sirtuins in renal health and disease","volume":"29","author":"Morigi","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib16","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1002\/jcp.30084","article-title":"Molecular pathophysiology of acute kidney injury: the role of sirtuins and their interactions with other macromolecular players","volume":"236","author":"Rahbar Saadat","year":"2021","journal-title":"J Cell Physiol"},{"key":"2022112304495807900_bib17","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/ajt.13106","article-title":"Class-specific histone\/protein deacetylase inhibition protects against renal ischemia reperfusion injury and fibrosis formation","volume":"15","author":"Levine","year":"2015","journal-title":"Am J Transplant"},{"key":"2022112304495807900_bib18","doi-asserted-by":"crossref","first-page":"F303","DOI":"10.1152\/ajprenal.00102.2014","article-title":"Class I HDAC activity is required for renal protection and regeneration after acute kidney injury","volume":"307","author":"Tang","year":"2014","journal-title":"Am J Physiol Ren Physiol"},{"key":"2022112304495807900_bib19","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s00467-012-2320-8","article-title":"HDAC inhibitors in kidney development and disease","volume":"28","author":"Brilli","year":"2013","journal-title":"Pediatric Nephrol"},{"key":"2022112304495807900_bib20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41419-018-0374-7","article-title":"Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells","volume":"9","author":"Liu","year":"2018","journal-title":"Cell Death Dis"},{"key":"2022112304495807900_bib21","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ki.2015.164","article-title":"Heterogeneity of epigenetic changes at ischemia\/reperfusion- and endotoxin-induced acute kidney injury genes","volume":"88","author":"Mar","year":"2015","journal-title":"Kidney Int"},{"key":"2022112304495807900_bib22","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1007\/s00467-020-04866-z","article-title":"Sirtuins play critical and diverse roles in acute kidney injury","volume":"36","author":"Peasley","year":"2021","journal-title":"Pediatr Nephrol"},{"key":"2022112304495807900_bib23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.kint.2018.08.037","article-title":"The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury","volume":"95","author":"Sp\u00e4th","year":"2019","journal-title":"Kidney Int"},{"key":"2022112304495807900_bib24","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1681\/ASN.2014030226","article-title":"SIRT2 regulates LPS-Induced renal tubular CXCL2 and CCL2 expression","volume":"26","author":"Jung","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib25","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/ndt\/gfaa042","article-title":"SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1","volume":"35","author":"Jung","year":"2020","journal-title":"Nephrol Dialy Transplant"},{"key":"2022112304495807900_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10495-016-1341-3","article-title":"SIRT2-mediated FOXO3a deacetylation drives its nuclear translocation triggering Fasl-induced cell apoptosis during renal ischemia reperfusion","volume":"22","author":"Wang","year":"2017","journal-title":"Apoptosis"},{"key":"2022112304495807900_bib27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s13046-020-01719-3","article-title":"Nicotinamide inhibits melanoma in vitro and in vivo","volume":"39","author":"Scatozza","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"2022112304495807900_bib28","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/s41418-018-0069-8","article-title":"SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH-terminal kinase","volume":"25","author":"Sarikhani","year":"2018","journal-title":"Cell Death Differ"},{"key":"2022112304495807900_bib29","doi-asserted-by":"crossref","first-page":"e00257","DOI":"10.1128\/MCB.00257-19","article-title":"E3 ubiquitin ligase HRD1 promotes lung tumorigenesis by promoting sirtuin 2 ubiquitination and degradation","volume":"40","author":"Liu","year":"2020","journal-title":"Mol Cell Biol"},{"key":"2022112304495807900_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10495-015-1190-5","article-title":"Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity","volume":"21","author":"Trist\u00e3o","year":"2016","journal-title":"Apoptosis"},{"key":"2022112304495807900_bib31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"2022112304495807900_bib32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41467-017-00496-6","article-title":"The cytoplasmic nuclear receptor RAR\u03b3 controls RIP1 initiated cell death when cIAP activity is inhibited","volume":"8","author":"Xu","year":"2017","journal-title":"Nat Commun"},{"key":"2022112304495807900_bib33","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.molcel.2014.10.021","article-title":"RIP3 induces apoptosis independent of pronecrotic kinase activity","volume":"56","author":"Mandal","year":"2014","journal-title":"Mol Cell"},{"key":"2022112304495807900_bib34","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ceb.2020.02.004","article-title":"New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8","volume":"63","author":"Schwarzer","year":"2020","journal-title":"Curr Opin Cell Biol"},{"key":"2022112304495807900_bib35","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1073\/pnas.1716578115","article-title":"TWEAK and RIPK1 mediate a second wave of cell death during AKI","volume":"115","author":"Martin-Sanchez","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112304495807900_bib36","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1073\/pnas.1916427117","article-title":"Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke","volume":"117","author":"Naito","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022112304495807900_bib37","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.1038\/nature13024","article-title":"Is SIRT2 required for necroptosis?","volume":"506","author":"Newton","year":"2014","journal-title":"Nature"},{"key":"2022112304495807900_bib38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/cdd.2015.60","article-title":"Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner","volume":"23","author":"Preyat","year":"2016","journal-title":"Cell Death Differ"},{"key":"2022112304495807900_bib39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/cr.2010.175","article-title":"NF-\u03baB in the regulation of epithelial homeostasis and inflammation","volume":"21","author":"Wullaert","year":"2011","journal-title":"Cell Res"},{"key":"2022112304495807900_bib40","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1681\/ASN.2010020218","article-title":"NF-kappaB in renal inflammation","volume":"21","author":"Sanz","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib41","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)81375-6","article-title":"Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death","volume":"87","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"2022112304495807900_bib42","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1681\/ASN.2005080894","article-title":"Low doses of ouabain protect from serum deprivation-triggered apoptosis and stimulate kidney cell proliferation via activation of NF-kappaB","volume":"17","author":"Li","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s10495-013-0939-y","article-title":"NF-\u03baB p65 recruited SHP regulates PDCD5-mediated apoptosis in cancer cells","volume":"19","author":"Murshed","year":"2014","journal-title":"Apoptosis"},{"key":"2022112304495807900_bib44","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/35009130","article-title":"Role of NF-kappaB in p53-mediated programmed cell death","volume":"404","author":"Ryan","year":"2000","journal-title":"Nature"},{"key":"2022112304495807900_bib45","doi-asserted-by":"crossref","first-page":"e115947","DOI":"10.1371\/journal.pone.0115947","article-title":"The restrained expression of NF-kB in renal tissue ameliorates folic acid induced acute kidney injury in mice","volume":"10","author":"Kumar","year":"2015","journal-title":"PLoS One"},{"key":"2022112304495807900_bib46","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1681\/ASN.2015070748","article-title":"Tubular epithelial NF-\u03baB activity regulates ischemic AKI","volume":"27","author":"Mark\u00f3","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib47","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1038\/s41467-019-12640-5","article-title":"DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering","volume":"10","author":"Milanese","year":"2019","journal-title":"Nat Commun"},{"key":"2022112304495807900_bib48","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1038\/s41467-020-19317-4","article-title":"An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline","volume":"11","author":"Trzeciakiewicz","year":"2020","journal-title":"Nat Commun"},{"key":"2022112304495807900_bib49","doi-asserted-by":"crossref","first-page":"101300","DOI":"10.1016\/j.redox.2019.101300","article-title":"Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation","volume":"26","author":"Mayorov","year":"2019","journal-title":"Redox Biol"},{"key":"2022112304495807900_bib50","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/ajt.12043","article-title":"Comparing molecular assessment of implantation biopsies with histologic and demographic risk assessment","volume":"13","author":"Kreepala","year":"2013","journal-title":"Am J Transplant"},{"key":"2022112304495807900_bib51","doi-asserted-by":"crossref","first-page":"e104164","DOI":"10.1371\/journal.pone.0104164","article-title":"Molecular pathogenesis of post-transplant acute kidney injury: assessment of whole-genome mRNA and miRNA profiles","volume":"9","author":"Wilflingseder","year":"2014","journal-title":"PLoS One"},{"key":"2022112304495807900_bib52","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1681\/ASN.2011090887","article-title":"Molecular phenotypes of acute kidney injury in kidney transplants","volume":"23","author":"Famulski","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"2022112304495807900_bib53","doi-asserted-by":"crossref","first-page":"16328","DOI":"10.1074\/jbc.RA120.015110","article-title":"SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells","volume":"295","author":"Kim","year":"2020","journal-title":"J Biol Chem"},{"key":"2022112304495807900_bib54","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1126\/science.aap8411","article-title":"VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma","volume":"361","author":"Zhang","year":"2018","journal-title":"Science"},{"key":"2022112304495807900_bib55","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.ajhg.2020.04.008","article-title":"Systems genetics in human endothelial cells identifies non-coding variants modifying enhancers, expression, and complex disease traits","volume":"106","author":"Stolze","year":"2020","journal-title":"Am J Hum Genet"},{"key":"2022112304495807900_bib56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"ENCODE Project Consortium","year":"2012","journal-title":"Nature"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfac164\/44326500\/gfac164.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/37\/12\/2366\/47203114\/gfac164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/37\/12\/2366\/47203114\/gfac164.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T04:50:41Z","timestamp":1669179041000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/37\/12\/2366\/6576344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,30]]},"references-count":56,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,4,30]]},"published-print":{"date-parts":[[2022,11,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfac164","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12]]},"published":{"date-parts":[[2022,4,30]]}}}