{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:14:32Z","timestamp":1793330072340,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Michael G. DeGroote Centre for Medicinal Cannabis Research at McMaster University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cannabis is frequently used recreationally and medicinally, including for symptom management in patients with kidney disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We elicited the views of Canadian adults with kidney disease regarding their cannabis use. Participants were asked whether they would try cannabis for anxiety, depression, restless legs, itchiness, fatigue, chronic pain, decreased appetite, nausea\/vomiting, sleep, cramps and other symptoms. The degree to which respondents considered cannabis for each symptom was assessed with a modified Likert scale ranging from 1 to 5 (1, definitely would not; 5, definitely would). Multilevel multivariable linear regression was used to identify respondent characteristics associated with considering cannabis for symptom control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 320 respondents, 290 (90.6%) were from in-person recruitment (27.3% response rate) and 30 (9.4%) responses were from online recruitment. A total of 160\/320 respondents (50.2%) had previously used cannabis, including smoking [140 (87.5%)], oils [69 (43.1%)] and edibles [92 (57.5%)]. The most common reasons for previous cannabis use were recreation [84\/160 (52.5%)], pain alleviation [63\/160 (39.4%)] and sleep enhancement [56\/160 (35.0%)]. Only 33.8% of previous cannabis users thought their physicians were aware of their cannabis use. More than 50% of respondents probably would or definitely would try cannabis for symptom control for all 10 symptoms. Characteristics independently associated with interest in trying cannabis for symptom control included symptom type (pain, sleep, restless legs), online respondent {\u03b2\u00a0=\u00a00.7 [95% confidence interval (CI) 0.1\u20131.4]} and previous cannabis use [\u03b2\u00a0=\u00a01.2 (95% CI 0.9\u20131.5)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many patients with kidney disease use cannabis and there is interest in trying cannabis for symptom control.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ndt\/gfac226","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T17:31:35Z","timestamp":1658856695000},"page":"922-931","source":"Crossref","is-referenced-by-count":12,"title":["Patient views regarding cannabis use in chronic kidney disease and kidney failure: a survey study"],"prefix":"10.1093","volume":"38","author":[{"given":"David","family":"Collister","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Alberta , Edmonton , AB, Canada"},{"name":"Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg , MB, Canada"},{"name":"Department of Anesthesia, McMaster University , Hamilton , ON, Canada"},{"name":"Population Health Research Institute , Hamilton , ON, Canada , Chronic Disease Innovation Centre, Winnipeg , MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen","family":"Herrington","sequence":"additional","affiliation":[{"name":"Can-SOLVE CKD, University of British Columbia , Vancouver , BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Delgado","sequence":"additional","affiliation":[{"name":"Can-SOLVE CKD, University of British Columbia , Vancouver , BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-0358","authenticated-orcid":false,"given":"Reid","family":"Whitlock","sequence":"additional","affiliation":[{"name":"Chronic Disease Innovation Centre , Winnipeg , MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Tennankore","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Dalhousie University , Nova Scotia Health Authority, Halifax , NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navdeep","family":"Tangri","sequence":"additional","affiliation":[{"name":"Department of Medicine, Rady Faculty of Health Sciences, University of Manitoba , Winnipeg , MB, Canada"},{"name":"Chronic Disease Innovation Centre , Winnipeg , MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Goupil","sequence":"additional","affiliation":[{"name":"Division of Nephrology , H\u00f4pital du Sacr\u00e9-C\u0153ur de Montr\u00e9al, Montreal , QC, Canada"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal , QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie-Claire","family":"Nadeau-Fredette","sequence":"additional","affiliation":[{"name":"Division of Nephrology , H\u00f4pital Maisonneuve-Rosemont, Montreal , QC, Canada"},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Montr\u00e9al , Montreal , QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara N","family":"Davison","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Alberta , Edmonton , AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Wald","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, University of Toronto , Toronto , ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Walsh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, McMaster University , Hamilton , ON, Canada"},{"name":"Canada Population Health Research Institute , Hamilton , ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.ackd.2006.10.001","article-title":"The prevalence of symptoms in end-stage renal disease: a systematic review","volume":"14","author":"Murtagh","year":"2007","journal-title":"Adv Chronic Kidney Dis"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2215\/CJN.00990207","article-title":"Renal provider recognition of symptoms in patients on maintenance hemodialysis","volume":"2","author":"Weisbord","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2215\/CJN.01610214","article-title":"Setting research priorities for patients on or nearing dialysis","volume":"9","author":"Manns","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/j.ajkd.2017.05.018","article-title":"Treatment of uremic pruritus: a systematic review","volume":"70","author":"Simonsen","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"2023033113134376200_","first-page":"CD012625","article-title":"Interventions for improving sleep quality in people with chronic kidney disease","volume":"5","author":"Natale","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/sdi.12196","article-title":"Pain in chronic kidney disease: a scoping review","volume":"27","author":"Davison","year":"2014","journal-title":"Semin Dial"},{"key":"2023033113134376200_","first-page":"CD010690","article-title":"Interventions for chronic kidney disease-associated restless legs syndrome","volume":"11","author":"Gopaluni","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1053\/j.ajkd.2017.06.020","article-title":"Marijuana and cannabinoids in ESRD and earlier stages of CKD","volume":"71","author":"Rein","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"2054358119828391","DOI":"10.1177\/2054358119828391","article-title":"A review of cannabis in chronic kidney disease symptom management","volume":"6","author":"Ho","year":"2019","journal-title":"Can J Kidney Health Dis"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"911","DOI":"10.2215\/CJN.11560821","article-title":"Cannabinoids for symptom management in patients with kidney failure: a narrative review","volume":"17","author":"Worth","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.bjp.0707442","article-title":"The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin","volume":"153","author":"Pertwee","year":"2008","journal-title":"Br J Pharmacol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/bs.apha.2017.05.003","article-title":"Cannabinoids and pain: sites and mechanisms of action","volume":"80","author":"Starowicz","year":"2017","journal-title":"Adv Pharmacol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.3390\/ph3092930","article-title":"Mechanisms of broad-spectrum antiemetic efficacy of cannabinoids against chemotherapy-induced acute and delayed vomiting","volume":"3","author":"Darmani","year":"2010","journal-title":"Pharmaceuticals (Basel)"},{"key":"2023033113134376200_","first-page":"CD012182","article-title":"Cannabis-based medicines for chronic neuropathic pain in adults","volume":"3","author":"Mucke","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"2023033113134376200_","first-page":"CDd009464","article-title":"Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy","volume":"11","author":"Smith","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2023033113134376200_","first-page":"CD005175","article-title":"The medical use of cannabis for reducing morbidity and mortality in patients with HIV\/AIDS","volume":"4","author":"Lutge","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0895-4356(99)00103-1","article-title":"Stepwise selection in small data sets: a simulation study of bias in logistic regression analysis","volume":"52","author":"Steyerberg","year":"1999","journal-title":"J Clin Epidemiol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jclinepi.2014.12.014","article-title":"The number of subjects per variable required in linear regression analyses","volume":"68","author":"Austin","year":"2015","journal-title":"J Clin Epidemiol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"2054358120954944","DOI":"10.1177\/2054358120954944","article-title":"Cannabis use for restless legs syndrome and uremic pruritus in in patients treated with maintenance dialysis: a survey","volume":"7","author":"Samaha","year":"2020","journal-title":"Can J Kidney Health Dis"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jpainsymman.2020.08.003","article-title":"Nephrologist views regarding cannabinoid use in advanced chronic kidney disease and dialysis: a survey","volume":"61","author":"Collister","year":"2021","journal-title":"J Pain Symptom Manage"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/phar.1187","article-title":"The pharmacologic and clinical effects of medical cannabis","volume":"33","author":"Borgelt","year":"2013","journal-title":"Pharmacotherapy"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/da.22664","article-title":"Is cannabis treatment for anxiety, mood, and related disorders ready for prime time?","volume":"34","author":"Turna","year":"2017","journal-title":"Depress Anxiety"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.smrv.2014.02.005","article-title":"The effects of cannabinoid administration on sleep: a systematic review of human studies","volume":"18","author":"Gates","year":"2014","journal-title":"Sleep Med Rev"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"13030\/qt7pn8c0sb","DOI":"10.5070\/D3246040706","article-title":"Cannabinoids in dermatology: a scoping review","volume":"24","author":"Eagleston","year":"2018","journal-title":"Dermatol Online J"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.sleep.2017.04.019","article-title":"Cannabis for restless legs syndrome: a report of six patients","volume":"36","author":"Megelin","year":"2017","journal-title":"Sleep Med"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1001\/jama.2015.6358","article-title":"Cannabinoids for medical use: a systematic review and meta-analysis","volume":"313","author":"Whiting","year":"2015","journal-title":"JAMA"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"n1034","DOI":"10.1136\/bmj.n1034","article-title":"Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials","volume":"374","author":"Wang","year":"2021","journal-title":"BMJ"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"zsab234","DOI":"10.1093\/sleep\/zsab234","article-title":"Medical cannabis and cannabinoids for impaired sleep: a systematic review and meta-analysis of randomized clinical trials","volume":"45","author":"AminiLari","year":"2021","journal-title":"Sleep"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S2215-0366(19)30401-8","article-title":"Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis","volume":"6","author":"Black","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1503\/cmaj.071178","article-title":"Adverse effects of medical cannabinoids: a systematic review","volume":"178","author":"Wang","year":"2008","journal-title":"CMAJ"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S2215-0366(20)30074-2","article-title":"Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis","volume":"7","author":"Hindley","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1111\/bcp.13635","article-title":"Gaps in predicting clinical doses for cannabinoids therapy: overview of issues for pharmacokinetics and pharmacodynamics modelling","volume":"84","author":"Liu","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3389\/fphar.2018.01365","article-title":"A systematic review on the pharmacokinetics of cannabidiol in humans","volume":"9","author":"Millar","year":"2018","journal-title":"Front Pharmacol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1097\/TP.0000000000002599","article-title":"Cannabis dependence or abuse in kidney transplantation: implications for posttransplant outcomes","volume":"103","author":"Alhamad","year":"2019","journal-title":"Transplantation"},{"key":"2023033113134376200_","doi-asserted-by":"publisher","DOI":"10.1089\/can.2021.0044","article-title":"Cannabis use and risk of acute kidney injury in patients with advanced chronic kidney disease transitioning to dialysis","author":"Potukuchi","year":"2021","journal-title":"Cannabis Cannabinoid Res"},{"key":"2023033113134376200_","doi-asserted-by":"publisher","DOI":"10.1089\/can.2021.0086","article-title":"Long-term frequent cannabis use and related serum cannabinoid levels are not associated with kidney dysfunction","author":"Bonnet","year":"2021","journal-title":"Cannabis Cannabinoid Res"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.2215\/CJN.01530217","article-title":"Marijuana use and estimated glomerular filtration rate in young adults","volume":"12","author":"Ishida","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1477-7517-10-2","article-title":"Perceptions of cannabis as a stigmatized medicine: a qualitative descriptive study","volume":"10","author":"Bottorff","year":"2013","journal-title":"Harm Reduct J"},{"key":"2023033113134376200_","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jamainternmed.2019.7517","article-title":"Trends in cannabis use among older adults in the United States, 2015\u20132018","volume":"180","author":"Han","year":"2020","journal-title":"JAMA Intern Med"},{"key":"2023033113134376200_"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfac226\/48837496\/gfac226.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/38\/4\/922\/49715286\/gfac226.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/38\/4\/922\/49715286\/gfac226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T00:15:11Z","timestamp":1700871311000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/38\/4\/922\/6650227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,26]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7,26]]},"published-print":{"date-parts":[[2023,3,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfac226","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4]]},"published":{"date-parts":[[2022,7,26]]}}}