{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:11:33Z","timestamp":1788541893815,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Publique\u2013H\u00f4pitaux de Paris"},{"name":"D\u00e9l\u00e9gation \u00e0 la Recherche Clinique et \u00e0 l'Innovation"},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programme Hospitalier de Recherche Clinique","award":["2011-003"],"award-info":[{"award-number":["2011-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We determine the benefit of pulsed methylprednisolone for improving kidney function in patients with sarcoidosis tubulointerstitial nephritis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter, prospective, randomized, open-label, controlled trial in patients with biopsy-proven acute tubulointerstitial nephritis caused by sarcoidosis at 21 sites in France. Patients were randomly assigned to receive a methylprednisolone pulse 15\u00a0mg\/kg\/day for 3 days, then oral prednisone (MP group) or oral prednisone 1\u00a0mg\/kg\/day alone (PRD group). The primary end point was a positive response at 3 months, defined as a doubling of estimated glomerular filtration rate (eGFR) compared with the eGFR before randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We randomized 40 participants. Baseline eGFR before PRD was 22\u00a0mL\/min\/1.73m2 {interquartile range [IQR], 16\u201344} and before MP was 25\u00a0mL\/min\/1.73m2 (IQR, 22\u201336) (P\u00a0=\u00a0.3). The two groups did not differ in underlying pathological lesions, including mean percentage of interstitial fibrosis and intensity of interstitial infiltrate. In the intent-to-treat population, the median eGFR at 3 months did not significantly differ between the PRD and MP groups: 45 (IQR, 34\u201374) and 46 (IQR, 39\u201365) mL\/min\/1.73m2. The primary end point at 3 months was achieved in 16 of 20 (80%) PRD patients and 10 of 20 (50%) MP patients (P\u00a0=\u00a0.0467). The eGFR was similar between the two groups after 1, 3, 6, and 12 months of treatment. For both groups, eGFR at 1 month was strongly correlated with eGFR at 12 months (P\u00a0&amp;lt;\u00a0.0001). The two groups did not differ in severe adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with a standard oral steroid regimen, intravenous MP may have no supplemental benefit for renal function in patients with tubulointerstitial nephritis caused by sarcoidosis.<\/jats:p>\n                    <jats:p>Trial Registration: ClinicalTrials.gov: NCT01652417; EudraCT: 2012\u2013000149-11<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfac227","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T08:40:57Z","timestamp":1662367257000},"page":"961-968","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy and safety of methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis: a randomized, open-label, controlled clinical trial"],"prefix":"10.1093","volume":"38","author":[{"given":"Matthieu","family":"Mahevas","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre National de R\u00e9f\u00e9rence des Cytop\u00e9nies Auto-immunes de l'adulte, H\u00f4pital Henri Mondor, Universite Paris Est Creteil , Assistance Publique H\u00f4pitaux de Paris, Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Department, Hopital Henri Mondor , Assistance Publique-H\u00f4pitaux de Paris, Cr\u00e9teil , France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Institut Mondor de Recherche Biom\u00e9dicale, Universit\u00e9 Paris-Est Creteil , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Clinical Research 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