{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:25:46Z","timestamp":1792009546459,"version":"4.4.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004824","name":"Danish Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004915","name":"Danish Kidney Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004915","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Region Zealand Research Foundation"},{"name":"Ejnar Danielsens Foundation"},{"name":"Helen and Ejnar Bj\u00f8rnows Foundation"},{"name":"Beckett Foundation"},{"name":"Karen Elise Jensens Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Vitamin K deficiency is highly prevalent in patients on dialysis and may contribute to their low bone mineral density (BMD) and increased risk of fracture. This study investigated the effect of menaquinone-7 (MK-7) supplementation on BMD in patients on chronic dialysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a multicentre, double-blind, placebo-controlled intervention trial, 123 patients on chronic dialysis were randomised to a daily oral supplement of either MK-7 360\u00a0\u00b5g or placebo for 2\u00a0years. BMD of the distal radius (1\/3, mid, ultradistal and total), femoral neck, lumbar spine (L1\u2013L4) and whole body was assessed by dual-energy X-ray absorptiometry. Serum levels of vitamin K1 and MK-7 and plasma levels of total osteocalcin, dephosphorylated-uncarboxylated matrix Gla protein and protein induced by vitamin K absence II were measured to assess vitamin K status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After 2\u00a0years, an accelerated BMD loss of the 1\/3 distal radius was found with MK-7 supplementation {mean difference of changes relative to placebo \u22120.023\u00a0g\/cm2 [95% confidence interval (CI) \u22120.039 to \u22120.008]}, whereas the decrease in lumbar spine BMD seen in the placebo group was prevented [mean difference of changes between groups 0.050\u00a0g\/cm2 (95% CI 0.015\u20130.085)]. No significant effects were observed at the remaining skeletal sites. Vitamin K status strongly improved in MK-7-supplemented participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with placebo, an accelerated BMD loss of the 1\/3 distal radius was found after 2\u00a0years of MK-7 supplementation, whereas a decline in lumbar spine BMD was prevented. As such, MK-7 supplementation might modify BMD site-specifically in patients on dialysis. In aggregate, our findings do not support MK-7 supplementation to preserve bone in patients on dialysis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfac315","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:05:49Z","timestamp":1670025949000},"page":"2131-2142","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial"],"prefix":"10.1093","volume":"38","author":[{"given":"Karin","family":"Levy-Schousboe","sequence":"first","affiliation":[{"name":"Department of Medicine, Zealand University Hospital , Roskilde , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Marckmann","sequence":"additional","affiliation":[{"name":"Department of Medicine S\u00f8nderborg-T\u00f8nder, Hospital S\u00f8nderjylland , S\u00f8nderborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Frimodt-M\u00f8ller","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center , Copenhagen , Denmark"},{"name":"Department of Nephrology, Herlev University Hospital , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian D","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista D","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens D","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Aarhus University Hospital , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Strandhave","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Aalborg University Hospital , Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Sandstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zealand University Hospital , Roskilde , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette F","family":"Hitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Zealand University Hospital , K\u00f8ge , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Langdahl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , Aarhus , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University , Aarhus , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , Aalborg , Denmark"},{"name":"Steno Diabetes Center North Denmark, Aalborg University Hospital , Aalborg , Denmark"},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus L","family":"Brasen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Lilleb\u00e6lt Hospital, University Hospital of Southern Denmark , Denmark"},{"name":"Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Schmedes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Lilleb\u00e6lt Hospital, University Hospital of Southern Denmark , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna S","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Lilleb\u00e6lt Hospital, University Hospital of Southern Denmark , Denmark"},{"name":"Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas R","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark"},{"name":"Department of Clinical Biochemistry , Rigshospitalet, Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens B","family":"Fr\u00f8kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University , Aalborg , Denmark"},{"name":"Department of Radiology, Aalborg University Hospital , Aalborg , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels E","family":"Frandsen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Zealand University Hospital , Roskilde , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Petersen","sequence":"additional","affiliation":[{"name":"Open Patient Data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Herlev 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