{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:28:02Z","timestamp":1790436482830,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on use of interleukin (IL)-1 blockers in kidney transplant recipients (KTRs) with familial Mediterranean fever (FMF) are very limited. We aimed to evaluate the efficacy and safety of anakinra and canakinumab in the transplantation setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, we included KTRs who suffered from AA amyloidosis caused by FMF and treated with anakinra or canakinumab (study group, n\u00a0=\u00a036). Using propensity score matching, we selected 36 patients without FMF or amyloidosis from our database of 696 KTRs as the control group. Primary outcomes were patient and graft survival. Biopsy-confirmed graft rejection, changes in estimated glomerular filtration rate (eGFR), high-sensitivity CRP (hsCRP), erythrocyte sedimentation rate (ESR), proteinuria and number of monthly attacks were secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All KTRs with FMF began IL-1 blocker therapy with anakinra and nine (25%) were switched to canakinumab. Overall death was more frequent in the study group (19.4%\u00a0vs 0%) (P\u00a0=\u00a0.005); however, overall graft loss was comparable between study (27.8%) and control groups (36.1%) (P\u00a0=\u00a0.448). Five- and 10-year graft survival rates were significantly higher in the study group (94.4% and 83.3%, respectively) than in the control group (77.8% and 63.9%, respectively) (P\u00a0=\u00a0.014 and P\u00a0&amp;lt;\u00a0.001, respectively). Rejections were numerically lower in study group (8.3% vs 25%), but it did not reach to statistical significance (P\u00a0=\u00a0.058). When compared with the pre-treatment period, with IL-1 blockers, the number of attacks per month (P\u00a0&amp;lt;\u00a0.001), and eGFR (P\u00a0=\u00a0.004), hsCRP (P\u00a0&amp;lt;\u00a0.001) and ESR (P\u00a0=\u00a0.026) levels were lower throughout the follow-up, whereas proteinuria levels were not.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anakinra and canakinumab are effective in KTRs suffering from FMF; however, the mortality rate may be of concern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfac335","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T11:56:18Z","timestamp":1671623778000},"page":"1327-1336","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of interleukin-1 blockers in kidney transplant recipients with familial Mediterranean fever: a propensity score\u2013matched cohort study"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-8154","authenticated-orcid":false,"given":"Safak","family":"Mirioglu","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"},{"name":"Division of Nephrology, Department of Internal Medicine, Bezmialem Vakif University School of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Burak","family":"Dirim","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Bektas","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Demir","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz Burak","family":"Tor","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Ozluk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isin","family":"Kilicaslan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur Akin","family":"Oto","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Yalcinkaya","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasar","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul University Istanbul Faculty of Medicine , Istanbul , Turkey"},{"name":"Center for Abdominal Transplantation, Saint Louis University School of Medicine , Saint Louis, MO , 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