{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:29:56Z","timestamp":1790688596872,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Outcomes of a combination of peritoneal dialysis (PD) and once-weekly haemodialysis (PD\u00a0+\u00a0HD) have not been extensively studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This prospective cohort study using the Japanese Society for Dialysis Therapy Renal Data Registry included those who transitioned from PD to PD\u00a0+\u00a0HD therapy or thrice-weekly HD from 2011 to 2018. Exposure was PD\u00a0+\u00a0HD therapy compared with thrice-weekly HD. The outcome was time to all-cause or cause-specific death. Associations between PD\u00a0+\u00a0HD therapy and outcomes were examined by Cox regression. Sensitivity analyses were performed by propensity score (PS) matching, PS matching with a shared frailty model in which dialysis facilities were treated as a random effect, inverse probability weighting (IPW), PS adjustment, PS stratification, competing risk regression and on-treatment analyses in which data were censored at the transition to thrice-weekly HD for those on PD\u00a0+\u00a0HD therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the study period, 1001 subjects transitioned to PD\u00a0+\u00a0HD therapy and 2031 to thrice-weekly HD. During a median follow-up of 3.5\u00a0years, 575 subjects died. All-cause, cardiovascular, congestive heart failure\u2013related or infection-related mortality were not significantly different between those on PD\u00a0+\u00a0HD and those on thrice-weekly HD [hazard ratio 0.95 (95% confidence interval 0.78\u20131.16), 1.26 (0.92\u20131.72), 1.24 (0.77\u20131.99) and 0.89 (0.57\u20131.39), respectively]. Sensitivity analyses yielded similar results except that PD\u00a0+\u00a0HD therapy was associated with significantly lower all-cause mortality by PS adjustment and PS matching with the shared frailty model and lower infection-related mortality by PS adjustment and IPW.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PD\u00a0+\u00a0HD therapy was associated with similar or potentially lower mortality compared with thrice-weekly HD. Considering a flexible lifestyle, PD\u00a0+\u00a0HD therapy could be a great option.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfad019","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T20:40:07Z","timestamp":1674506407000},"page":"2143-2151","source":"Crossref","is-referenced-by-count":6,"title":["Comparable outcomes between a combination of peritoneal dialysis with once-weekly haemodialysis and thrice-weekly haemodialysis: a prospective cohort study"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-0438","authenticated-orcid":false,"given":"Miho","family":"Murashima","sequence":"first","affiliation":[{"name":"Department of Nephrology, Nagoya City University, Graduate School of Medical Sciences , Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Nagoya City University, Graduate School of Medical Sciences , Nagoya, Japan"},{"name":"Department of Nephrology, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Abe","sequence":"additional","affiliation":[{"name":"Renal Data Registry Committee , Japanese Society for Dialysis Therapy, Tokyo, Japan"},{"name":"Division of Nephrology, Hypertension, and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuto","family":"Masakane","sequence":"additional","affiliation":[{"name":"Yabuki Hospital , Fukushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"2023092902512448000_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1526-0968.2004.00107.x","article-title":"Review of 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