{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:06:20Z","timestamp":1769515580916,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Flanders Research Fund","award":["52075"],"award-info":[{"award-number":["52075"]}]},{"name":"Flanders Research Fund","award":["G0C8920N"],"award-info":[{"award-number":["G0C8920N"]}]},{"name":"Flanders Research Fund","award":["G060623N"],"award-info":[{"award-number":["G060623N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,31]]},"DOI":"10.1093\/ndt\/gfad056","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T04:36:39Z","timestamp":1679459799000},"page":"1907-1911","source":"Crossref","is-referenced-by-count":1,"title":["Apelin is altered in subjects with autosomal dominant polycystic kidney disease and preserved kidney function"],"prefix":"10.1093","volume":"38","author":[{"given":"Peter","family":"Janssens","sequence":"first","affiliation":[{"name":"Department of Nephrology and Arterial Hypertension, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel , Brussels , Belgium"},{"name":"PKD research group, Department of Cellular and Molecular Medicine , KU Leuven, Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Cools","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel, Interfaculty Center Data processing and Statistics , Brussels , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"de Mota","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge de France- INSERM U1050\/CNRS UMR 7241, Center for Interdisciplinary Research in Biology , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Decuypere","sequence":"additional","affiliation":[{"name":"PKD research group, Department of Cellular and Molecular Medicine , KU Leuven, Leuven , Belgium"},{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain and Disease Research , KU Leuven, Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Torres","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine, Division of Nephrology and Hypertension , Rochester , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Martin","family":"Wissing","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Arterial Hypertension, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel , Brussels , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi","family":"Vennekens","sequence":"additional","affiliation":[{"name":"Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, VIB Center for Brain and Disease Research , KU Leuven, Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Bammens","sequence":"additional","affiliation":[{"name":"KU Leuven Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group , Leuven , Belgium"},{"name":"Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Llorens-Cortes","sequence":"additional","affiliation":[{"name":"Coll\u00e8ge de France- INSERM U1050\/CNRS UMR 7241, Center for Interdisciplinary Research in Biology , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djalila","family":"Mekahli","sequence":"additional","affiliation":[{"name":"PKD research group, Department of Cellular and Molecular Medicine , KU Leuven, Leuven , Belgium"},{"name":"Department of Pediatric Nephrology and Organ Transplantation, University Hospitals Leuven , Leuven , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"2023073100370989200_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(18)32782-X","article-title":"Autosomal dominant polycystic kidney disease","volume":"393","author":"Cornec-Le Gall","year":"2019","journal-title":"Lancet"},{"key":"2023073100370989200_bib2","first-page":"629","article-title":"Renal concentrating capacity is linked to blood pressure in children with autosomal dominant polycystic kidney disease","volume":"53","author":"Seeman","year":"2004","journal-title":"Physiol Res"},{"key":"2023073100370989200_bib3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ki.2012.225","article-title":"Autosomal dominant polycystic kidney disease is associated with central and nephrogenic defects in osmoregulation","volume":"82","author":"Ho","year":"2012","journal-title":"Kidney Int"},{"key":"2023073100370989200_bib4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.ajkd.2012.08.038","article-title":"Relationship of copeptin, a surrogate marker for arginine vasopressin, with change in total kidney volume and GFR decline in autosomal dominant polycystic kidney disease: results from the CRISP cohort","volume":"61","author":"Boertien","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"2023073100370989200_bib5","article-title":"The emerging role of the apelinergic system in kidney physiology and disease","author":"Janssens","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2023073100370989200_bib6","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1681\/ASN.2007070816","article-title":"Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli","volume":"19","author":"Azizi","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"2023073100370989200_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41581-021-00461-z","article-title":"The therapeutic potential of apelin in kidney disease","author":"Chapman","year":"2021","journal-title":"Nat Rev Nephrol"},{"key":"2023073100370989200_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ki.2008.199","article-title":"Effect of apelin on glomerular hemodynamic function in the rat kidney","volume":"74","author":"Hus-Citharel","year":"2008","journal-title":"Kidney Int"},{"key":"2023073100370989200_bib9","doi-asserted-by":"crossref","first-page":"18261","DOI":"10.1074\/jbc.M115.648238","article-title":"Apela Regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling","volume":"290","author":"Deng","year":"2015","journal-title":"J Biol Chem"},{"key":"2023073100370989200_bib10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1096\/fj.201600784R","article-title":"Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects","volume":"31","author":"Gerbier","year":"2017","journal-title":"FASEB J"},{"key":"2023073100370989200_bib11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41467-020-20560-y","article-title":"A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia","volume":"12","author":"Flahault","year":"2021","journal-title":"Nat Commun"},{"key":"2023073100370989200_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2013.08.007","article-title":"Apelin and copeptin: two opposite biomarkers associated with kidney function decline and cyst growth in autosomal dominant polycystic kidney disease","volume":"49","author":"Lacquaniti","year":"2013","journal-title":"Peptides"},{"key":"2023073100370989200_bib13","doi-asserted-by":"crossref","first-page":"906","DOI":"10.2215\/CJN.11311111","article-title":"Vasopressin, copeptin, and renal concentrating capacity in patients with autosomal dominant polycystic kidney disease without renal impairment","volume":"7","author":"Zittema","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023073100370989200_bib14","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1038\/s41598-022-11835-z","article-title":"On methods for the measurement of the apelin receptor ligand apelin","volume":"12","author":"Janssens","year":"2022","journal-title":"Sci Rep"},{"key":"2023073100370989200_bib15","article-title":"Vaptans or voluntary increased hydration to protect the kidney: how do they compare?","author":"Bankir","year":"2021","journal-title":"Nephrol Dial Transplant"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfad056\/50362505\/gfad056.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/38\/8\/1907\/50956402\/gfad056.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/38\/8\/1907\/50956402\/gfad056.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:37:32Z","timestamp":1690763852000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/38\/8\/1907\/7083023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,3,21]]},"published-print":{"date-parts":[[2023,7,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfad056","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,3,21]]}}}