{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:23:42Z","timestamp":1793949822242,"version":"4.8.0"},"reference-count":98,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre Research Incentive Fund"},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Evidence comparing different exercise modalities in individuals undergoing hemodialysis remains incipient. Our aim was to conduct a systematic review and network meta-analysis of randomized clinical trials to compare and synthesize the efficacy of five different intradialytic exercise modalities and home-based training in this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, setting, participants, and measurements<\/jats:title>\n                  <jats:p>Studies were searched in PubMed\/MEDLINE, Cochrane Library, Embase, Cinahl, and Scopus from their inception to 19 September 2022. We used traditional random-effects models and Bayesian network meta-analysis models. The risk of bias was assessed using the RoB v.2.0 tool, and the assessment of confidence in the results through the Confidence in Network Meta-Analysis (CINeMA) tool.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-eight studies involving 3326 participants were included. Our network meta-analysis showed that combined training was the intervention with the best performance to increase VO2 peak [mean difference (MD) = 3.94\u00a0ml\/kg\/min; 95% credible interval (CrI), 2.38 to 5.76] and to reduce diastolic blood pressure (MD = \u22125.19\u00a0mmHg; 95%CrI, \u22129.35 to \u22120.96) compared to the usual care group. Inspiratory muscle training was the intervention that most improved the 6-minute walk test distance (MD\u00a0=\u00a070.97\u00a0m; 95%CrI, 18.09 to 129.87). C-reactive protein decreased in resistance training (MD = \u22122.6\u00a0mg\/l; 95%CrI, \u22124.97 to \u22120.33) and aerobic training (MD = \u22121.4\u00a0mg\/l; 95%CrI, \u22123.15 to \u22120.06). Kt\/V improved in aerobic training (MD\u00a0=\u00a00.11; 95%CrI, 0.02 to 0.18), and SF-36 physical functioning outcomes improved in resistance training (MD\u00a0=\u00a010.66 points; 95%Crl, 1.91 to 20.22). No intradialytic exercise modality was superior to others or comparable with home-based training in improving the evaluated outcomes. Subgroup analysis revealed that exercise interventions &amp;gt;12 weeks improved functional capacity more than interventions \u226412 weeks, and that combined training reduces diastolic blood pressure only after 12 weeks of follow-up. Furthermore, our results suggest that moderate or moderate-to-vigorous intensity training leads to more pronounced improvements in functional capacity, whereas mild or mild-to-moderate intensity training does not have the same effect. In this review, most of the included studies were assessed as having some concern, which resulted in a low to very low level of confidence in the overall findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Both intradialytic training and home-based training can promote benefits for individuals undergoing hemodialysis, with no evidence of the superiority of either training modality over the other.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfad083","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T05:10:48Z","timestamp":1682745048000},"page":"2389-2406","source":"Crossref","is-referenced-by-count":36,"title":["Efficacy of six exercise-based interventions for individuals undergoing hemodialysis: a network meta-analysis of randomized clinical trials"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-8392","authenticated-orcid":false,"given":"Filipe","family":"Ferrari","sequence":"first","affiliation":[{"name":"Graduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul , Porto Alegre, RS , Brazil"},{"name":"Exercise Cardiology Research Group (CardioEx), Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, RS , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francini P","family":"Andrade","sequence":"additional","affiliation":[{"name":"Graduate Program in Pneumological Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul , Porto Alegre, RS , Brazil"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia , Maia , Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo S","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul , Porto Alegre, RS , Brazil"},{"name":"Exercise Cardiology Research Group (CardioEx), Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, RS , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia K","family":"Ziegelmann","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiology and Cardiovascular Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul , Porto Alegre, RS , Brazil"},{"name":"Graduate Program in Epidemiology, Universidade Federal do Rio Grande do Sul , Porto Alegre, RS , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Exercise Cardiology Research Group (CardioEx), Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, RS , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduarda S S","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Exercise Cardiology Research Group (CardioEx), Universidade Federal do Rio Grande do Sul, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, RS , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin C","family":"Barcellos","sequence":"additional","affiliation":[{"name":"Universidade Cat\u00f3lica de Pelotas , Pelotas, RS , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Stein","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiology and 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