{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:25:18Z","timestamp":1788481518123,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T00:00:00Z","timestamp":1687392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We investigated the effect of Post\u2013Acute COVID Syndrome or \u201clong-COVID\u201d on kidney function among patients followed in post-COVID recovery clinics (PCRC) in British Columbia, Canada.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Long-COVID patients referred to PCRC between July 2020 to April 2022, aged \u226518\u00a0years who had an estimated glomerular filtration rate (eGFR) value recorded at 3\u00a0months from the coronavirus disease 2019 (COVID-19) diagnosis (index) date were included. Those requiring renal replacement therapy prior to index date were excluded. Primary outcome was change in eGFR and urine albumin\u2013creatinine ratio (UACR) after COVID-19 infection. The proportion of patients in each of the six eGFR categories (&amp;lt;30, 30\u201344, 45\u201359, 60\u201389, 90\u2013120 and &amp;gt;120\u00a0mL\/min\/1.73\u00a0m2) and three UACR categories (&amp;lt;3, 3\u201330 and &amp;gt;30\u00a0mg\/mmol) in all of the study time points were calculated. Linear mixed model was used to investigate change in eGFR over time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study sample included 2212 long-COVID patients. Median age was 56\u00a0years, 51% were male. Half (\u223c47%\u201350%) of the study sample had normal eGFR (\u226590\u00a0mL\/min\/1.73\u00a0m2) from COVID-19 diagnosis to 12\u00a0months post-COVID and &amp;lt;5% of patients had an eGFR &amp;lt;30\u00a0mL\/min\/1.73\u00a0m2. There was an estimated 2.96\u00a0mL\/min\/1.73\u00a0m2 decrease in eGFR within 1\u00a0year after COVID-19 infection that was equivalent to 3.39% reduction from the baseline. Decline in eGFR was highest in patients hospitalized for COVID-19 (6.72%) followed by diabetic patients (6.15%). More than 40% of patients were at risk of CKD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>People with long-COVID experienced a substantial decline in eGFR within 1\u00a0year from the infection date. The prevalence of proteinuria appeared to be high. Close monitoring of kidney function is prudent among patients with persistent COVID-19 symptoms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfad121","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T05:08:31Z","timestamp":1687496911000},"page":"2816-2825","source":"Crossref","is-referenced-by-count":32,"title":["Long-term effect of COVID-19 infection on kidney function among COVID-19 patients followed in post-COVID-19 recovery clinics in British Columbia, Canada"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-7666","authenticated-orcid":false,"given":"Mohammad","family":"Atiquzzaman","sequence":"first","affiliation":[{"name":"BC Renal , Vancouver, British Columbia , Canada"},{"name":"Division of Nephrology, University of British Columbia , Vancouver, British Columbia , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn 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