{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:50:41Z","timestamp":1767192641922},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"MARIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Because of increased access to kidney transplantation in elderly subjects, the prevalence of monoclonal gammopathies of unknown significance (MGUS) in kidney transplantation (KT) is growing. However, little is known about the consequences of MGUS on long-term outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We identified 70 recipients with MGUS present at transplantation (KTMG) and 114 patients with MGUS occurring after KT (DNMG), among 3059 patients who underwent a KT in two French kidney transplantation centers. We compared outcomes of KTMG with those of matched controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Baseline characteristics were similar except for an older age in KTMG compared with the DNMG group (62 vs 57 years, P\u00a0=\u00a0.03). Transient MGUS occurred more frequently in DNMG patients (45% vs 24%, P\u00a0=\u00a0.007). When compared with matched controls without MGUS, KTMG patients showed higher frequency and earlier post-transplant solid cancers (15% vs 5%, P\u00a0=\u00a0.04) and a trend for more bacterial infections (63% vs 48%, P\u00a0=\u00a0.08), without difference regarding patient and graft survival, rejection episodes or hematological complications. KTMG patients with an abnormal kappa\/lambda ratio and\/or severe hypogammaglobulinemia at the time of KT experienced shorter overall survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MGUS detection at the time of KT is neither associated with a higher occurrence of graft rejection, nor adversely affects graft or overall survival. MGUS should not contraindicate KT. However, MGUS at the time of KT may be associated with higher risk of early neoplastic and infectious complications and warrants prolonged surveillance. Measurement of serum free light chain should be performed before transplant to refine the risk evaluation of KTMG patients and propose personalized follow-up and immunosuppression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfad144","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T13:37:24Z","timestamp":1688564244000},"page":"64-73","source":"Crossref","is-referenced-by-count":3,"title":["Monoclonal gammopathy of unknown significance in kidney transplanted patients: novel insights into long-term outcomes"],"prefix":"10.1093","volume":"39","author":[{"given":"Marie-Sophie","family":"Meuleman","sequence":"first","affiliation":[{"name":"Department of Nephrology and Transplantation , H\u00f4pital Necker, , France"},{"name":"APHP. Universit\u00e9 de Paris Cit\u00e9 , H\u00f4pital Necker, , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Mouyabi","sequence":"additional","affiliation":[{"name":"Department of Nephrology , CHU Poitiers, Vienne , France . Centre de r\u00e9f\u00e9rence \u00ab Amylose AL et autres maladies \u00e0 d\u00e9p\u00f4ts d'immunoglobuline monoclonales\u00bb"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Gueguen","sequence":"additional","affiliation":[{"name":"Department of Nephrology , CHU Tours, Idre et Loire , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Vicca","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory , H\u00f4pital Necker, APHP, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Divard","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation , H\u00f4pital Necker, , France"},{"name":"APHP. Universit\u00e9 de Paris Cit\u00e9 , H\u00f4pital Necker, , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Aubert","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation , H\u00f4pital Necker, , France"},{"name":"APHP. Universit\u00e9 de Paris Cit\u00e9 , H\u00f4pital Necker, , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Bienaim\u00e9","sequence":"additional","affiliation":[{"name":"Service d'Explorations Fonctionnelles r\u00e9nales, H\u00f4pital Necker, APHP. Universit\u00e9 de , Paris , France"},{"name":"Institut Necker Enfant Malade , INSERMU1151, Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Arnulf","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, H\u00f4pital Saint Louis, APHP, France. Universit\u00e9 de Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dany","family":"Anglicheau","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation , H\u00f4pital Necker, , France"},{"name":"APHP. Universit\u00e9 de Paris Cit\u00e9 , H\u00f4pital Necker, , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Bridoux","sequence":"additional","affiliation":[{"name":"Department of Nephrology , CHU Poitiers, Vienne , France . Centre de r\u00e9f\u00e9rence \u00ab Amylose AL et autres maladies \u00e0 d\u00e9p\u00f4ts d'immunoglobuline monoclonales\u00bb"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation , H\u00f4pital Necker, , France"},{"name":"APHP. Universit\u00e9 de Paris Cit\u00e9 , H\u00f4pital Necker, , France"},{"name":"Stress and cancer laboratory, INSERM U830, Institut Curie , Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"2023122005161180500_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41408-020-0303-8","article-title":"Prevalence of monoclonal gammopathy of undetermined significance in a large population with annual medical check-ups in China","volume":"10","author":"Han","year":"2020","journal-title":"Blood Cancer J"},{"key":"2023122005161180500_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJMoa1709974","article-title":"Long-term follow-up of monoclonal gammopathy of undetermined significance","volume":"378","author":"Kyle","year":"2018","journal-title":"N Engl J 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