{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:33:30Z","timestamp":1792640010994,"version":"4.5.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002997","name":"Dutch Kidney Foundation","doi-asserted-by":"publisher","award":["CP16.01"],"award-info":[{"award-number":["CP16.01"]}],"id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Dietary potassium (K+) has emerged as a modifiable factor for cardiovascular and kidney health in the general population, but its role in people with chronic kidney disease (CKD) is unclear. Here, we hypothesize that CKD increases the susceptibility to the negative effects of low and high K+ diets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We compared the effects of low, normal and high KChloride (KCl) diets and a high KCitrate diet for 4 weeks in male rats with normal kidney function and in male rats with CKD using the 5\/6th nephrectomy model (5\/6Nx).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with rats with normal kidney function, 5\/6Nx rats on the low KCl diet developed more severe extracellular and intracellular K+ depletion and more severe kidney injury, characterized by nephromegaly, infiltration of T cells and macrophages, decreased estimated glomerular filtration rate and increased albuminuria. The high KCl diet caused hyperkalemia, hyperaldosteronism, hyperchloremic metabolic acidosis and severe hypertension in 5\/6Nx but not in sham rats. The high KCitrate diet caused hypochloremic metabolic alkalosis but attenuated hypertension despite higher abundance of the phosphorylated sodium chloride cotransporter (pNCC) and similar levels of plasma aldosterone and epithelial sodium channel abundance. All 5\/6Nx groups had more collagen deposition than the sham groups and this effect was most pronounced in the high KCitrate group. Plasma aldosterone correlated strongly with kidney collagen deposition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CKD increases the susceptibility to negative effects of low and high K+ diets in male rats, although the injury patterns are different. The low K+ diet caused inflammation, nephromegaly and kidney function decline, whereas the high K+ diet caused hypertension, hyperaldosteronism and kidney fibrosis. High KCitrate attenuated the hypertensive but not the pro-fibrotic effect of high KCl, which may be attributable to K+-induced aldosterone secretion. Our data suggest that especially in people with CKD it is important to identify the optimal threshold of dietary K+ intake.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfad220","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:40:24Z","timestamp":1696905624000},"page":"795-807","source":"Crossref","is-referenced-by-count":12,"title":["Chronic kidney disease increases the susceptibility to negative effects of low and high potassium intake"],"prefix":"10.1093","volume":"39","author":[{"given":"Martin","family":"Gritter","sequence":"first","affiliation":[{"name":"Department of Internel Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center , Rotterdam , The Netherlands"},{"name":"Department of Internal Medicine, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Yu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Internel Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center , Rotterdam , The Netherlands"},{"name":"Department of Internal Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-9811","authenticated-orcid":false,"given":"Rosa D","family":"Wouda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Centers , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha M","family":"Musterd-Bhaggoe","sequence":"additional","affiliation":[{"name":"Department of Internel Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center , Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra L","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Pathology, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Kers","sequence":"additional","affiliation":[{"name":"Pathology, Leiden University Medical Center , Leiden , The Netherlands"},{"name":"Pathology, Amsterdam University Medical Center , Amsterdam , The Netherlands"},{"name":"Van \u2018t Hoff Institute for Molecular Sciences, University of Amsterdam , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ramakers","sequence":"additional","affiliation":[{"name":"Clinical Chemistry , Erasmus Medical Center, Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-7505","authenticated-orcid":false,"given":"Liffert","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Nephrology, Amsterdam University Medical Centers , Amsterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-8733","authenticated-orcid":false,"given":"Martin H","family":"de Borst","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander H J","family":"Danser","sequence":"additional","affiliation":[{"name":"Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC University Medical Center , Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-3571","authenticated-orcid":false,"given":"Ewout J","family":"Hoorn","sequence":"additional","affiliation":[{"name":"Department of Internel Medicine, Division of Nephrology and Transplantation, Erasmus Medical Center , Rotterdam , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris I","family":"Rotmans","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Leiden University Medical Center , Leiden , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"2024042523511086900_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJMoa1311989","article-title":"Association of urinary sodium and potassium excretion with blood pressure","volume":"371","author":"Mente","year":"2014","journal-title":"N 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