{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:45:09Z","timestamp":1768034709747,"version":"3.49.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Biomedicine Agency","award":["19REIN001"],"award-info":[{"award-number":["19REIN001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Recent evidence suggests an overestimation of the benefits associated with arteriovenous (AV) fistula versus graft in certain populations. We assessed hazards of all-cause and cause-specific hospitalization and death associated with AV access type in patients who started hemodialysis with a catheter in France, overall and by subgroups of age, sex and comorbidities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a target trial emulation including patients who initiated hemodialysis with a catheter from 2010 through 2018 and were followed by the REIN Registry. We identified first-created fistula or graft through the French national health-administrative database. We used joint frailty models to deal with recurrent hospitalizations and potential informative censoring by death, and inverse probability weighting to account for confounding.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From the 18\u2009800 patients included (mean age 68\u00a0\u00b1\u00a015 years, 35% women), 5% underwent AV graft creation first. The weighted hazard ratio (wHR) of all-cause hospitalization associated with graft was 1.08 [95% confidence interval (CI) 1.02 to 1.15], that of vascular access\u2013related hospitalization was 1.43 (95% CI 1.32 to 1.55), and those of cardiovascular- and infection-related hospitalizations were 1.14 (95% CI 1.03 to 1.26) and 1.11 (95% CI 0.97 to 1.28), respectively. Results were consistent for most subgroups, except that the highest hazard of all-cause, cardiovascular- and infection-related hospitalizations with graft was blunted in patients with comorbidities (i.e. diabetes, wHR 1.01, 95% CI 0.93 to 1.10; 1.10, 95% CI 0.96 to 1.26; and 0.94, 95% CI 0.78 to 1.12, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients starting hemodialysis with a catheter, AV graft creation is associated with increased hazard of vascular access\u2013related hospitalizations compared with fistula. This may not be the case for death or other causes of hospitalization.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfad251","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T03:59:13Z","timestamp":1701143953000},"page":"978-988","source":"Crossref","is-referenced-by-count":2,"title":["Arteriovenous access creation and hazards of hospitalization and death in patients starting hemodialysis"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0438-6487","authenticated-orcid":false,"given":"Natalia","family":"Alencar de Pinho","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bordeaux, INSERM, Bordeaux Population Health Research Center , UMR1219, CIC1401-EC, Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-7783","authenticated-orcid":false,"given":"Mathilde","family":"Prezelin-Reydit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux, INSERM, Bordeaux Population Health Research Center , UMR1219, CIC1401-EC, Bordeaux , France"},{"name":"Maison du Rein \u2013 AURAD \u00a0 Aquitaine, Gradignan , France"},{"name":"INSERM, Clinical Investigation Center-Clinical Epidemiology-CIC-1401 , Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Harambat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux, INSERM, Bordeaux Population Health Research Center , UMR1219, CIC1401-EC, Bordeaux , France"},{"name":"INSERM, Clinical Investigation Center-Clinical Epidemiology-CIC-1401 , Bordeaux , France"},{"name":"Department of Pediatric Nephrology, CHU de Bordeaux , Bordeaux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-660X","authenticated-orcid":false,"given":"C\u00e9cile","family":"Couchoud","sequence":"additional","affiliation":[{"name":"Registre REIN, Agence de la biom\u00e9decine, Saint Denis La Plaine , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Glaudet","sequence":"additional","affiliation":[{"name":"Cellule r\u00e9gionale REIN Limousin, Department of Nephrology , CHU Dupuytren 2, Limoges , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-573X","authenticated-orcid":false,"given":"Christian","family":"Combe","sequence":"additional","affiliation":[{"name":"INSERM, Clinical Investigation Center-Clinical Epidemiology-CIC-1401 , Bordeaux , France"},{"name":"Department of Nephrology Transplantation Dialysis and Apheresis, CHU de Bordeaux, Univ. 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