{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:48:09Z","timestamp":1792180089069,"version":"4.4.0"},"reference-count":156,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR332"],"award-info":[{"award-number":["TRR332"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STE2437\/4-1"],"award-info":[{"award-number":["STE2437\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR359"],"award-info":[{"award-number":["TRR359"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,27]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Neutrophils, the most abundant white blood cells in the human circulation, play crucial roles in various diseases, including kidney disease. Traditionally viewed as short-lived pro-inflammatory phagocytes that release reactive oxygen species, cytokines and neutrophil extracellular traps, recent studies have revealed their complexity and heterogeneity, thereby challenging this perception. Neutrophils are now recognized as transcriptionally active cells capable of proliferation and reverse migration, displaying phenotypic and functional heterogeneity. They respond to a wide range of signals and deploy various cargo to influence the activity of other cells in the circulation and in tissues. They can regulate the behavior of multiple immune cell types, exhibit innate immune memory, and contribute to both acute and chronic inflammatory responses while also promoting inflammation resolution in a context-dependent manner. Here, we explore the origin and heterogeneity of neutrophils, their functional diversity, and the cues that regulate their effector functions. We also examine their emerging role in infectious and non-infectious diseases with a particular emphasis on kidney disease. Understanding the complex behavior of neutrophils during tissue injury and inflammation may provide novel insights, thereby paving the way for potential therapeutic strategies to manage acute and chronic conditions. By deciphering their multifaceted role, targeted interventions can be developed to address the intricacies of neutrophil-mediated immune responses and improve disease outcomes.<\/jats:p>","DOI":"10.1093\/ndt\/gfad266","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T06:35:39Z","timestamp":1703054139000},"page":"1551-1564","source":"Crossref","is-referenced-by-count":47,"title":["Neutrophils\u2014biology and diversity"],"prefix":"10.1093","volume":"39","author":[{"given":"Daniela","family":"Maier-Begandt","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine Biomedical Center (BMC), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Alonso-Gonzalez","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Universit\u00e4t of M\u00fcnster , M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Klotz","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute for Translational Neurology, University Hospital M\u00fcnster , M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luise","family":"Erpenbeck","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital M\u00fcnster , M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-2542","authenticated-orcid":false,"given":"Jadwiga","family":"Jablonska","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen , Essen ,","place":["Germany"]},{"name":"German Cancer Consortium (DKTK) partner site D\u00fcsseldorf\/Essen , Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-7528","authenticated-orcid":false,"given":"Roland","family":"Immler","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine Biomedical Center (BMC), Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Hasenberg","sequence":"additional","affiliation":[{"name":"Institute of Experimental Immunology and Imaging, University Hospital Essen, University Duisburg-Essen , Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonina T","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Herrero-Cervera","sequence":"additional","affiliation":[{"name":"Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, Universit\u00e4t of M\u00fcnster , M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Aranda-Pardos","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Universit\u00e4t of M\u00fcnster , M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailey","family":"Flora","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine IV, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich , Munich ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zarbock","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital M\u00fcnster , M\u00fcnster ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2702-4163","authenticated-orcid":false,"given":"Sven","family":"Brandau","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen , Essen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Ludwig-Maximilians-University Hospital, Ludwig-Maximilians-University Munich , Munich 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