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It is currently recognized as a multifaceted player in kidney physiology and disease, with discrete roles for intracellular, urinary, interstitial and serum uromodulin. Among these, uromodulin modulates renal sodium handling through the regulation of tubular sodium transporters that reabsorb sodium and are targeted by diuretics, such as the loop diuretic\u2013sensitive Na+-K+-2Cl\u2212 cotransporter type 2 (NKCC2) and the thiazide-sensitive Na+\/Cl\u2212 cotransporter (NCC). Given these roles, the contribution of uromodulin to sodium-sensitive hypertension has been proposed. However, recent studies in humans suggest a more complex interaction between dietary sodium intake, uromodulin and blood pressure. This review presents an updated overview of the uromodulin's biology and its various roles, and focuses on the interaction between uromodulin and sodium-sensitive hypertension.<\/jats:p>","DOI":"10.1093\/ndt\/gfae008","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T01:09:30Z","timestamp":1705021770000},"page":"1073-1087","source":"Crossref","is-referenced-by-count":30,"title":["Uromodulin biology"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7054-1422","authenticated-orcid":false,"given":"Artemios G","family":"Karagiannidis","sequence":"first","affiliation":[{"name":"First Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki , Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-9635","authenticated-orcid":false,"given":"Marieta 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