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Baseline eGFRdiff was calculated using both absolute difference between cystatin C- and creatinine-based calculations (eGFRabdiff), and the ratio between them (eGFRrediff). Cox proportional hazards regression models were used to investigate the association between eGFRdiff and outcomes including all-cause mortality and incident CV events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 8129 individuals from INDEED (aged 60.7\u00a0\u00b1\u00a010.0\u00a0years), 1634 from NHANES (aged 62.5\u00a0\u00b1\u00a014.4\u00a0years) and 29\u00a0358 from UKB (aged 59.4\u00a0\u00b1\u00a07.3 years) were included. At baseline, 43.6%, 32.4% and 42.1% of participants in INDEED, NHANES and UKB, respectively, had an eGFRabdiff value \u226515\u00a0mL\/min\/1.73 m2. During a median follow-up of 3.8\u00a0years for INDEED, 15.2\u00a0years for NHANES and 13.5\u00a0years for UKB, a total of 430, 936 and 6143 deaths and a total of 481, 183 and 5583 CV events occurred, respectively. Each 1-standard deviation higher baseline eGFRabdiff was independently associated with a lower risk of all-cause mortality and CV events, with hazard ratios of 0.77 and 0.82 in INDEED, 0.70 and 0.68 in NHANES, and 0.66 and 0.78 in UKB. Similar results were observed for eGFRrediff.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>eGFRdiff represents a marker of adverse events for diabetes among general population. Monitoring both eGFRcys and eGFRcr yields additional prognostic information and has clinical utility in identifying high-risk individuals for mortality and CV events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfae011","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T06:57:10Z","timestamp":1707202630000},"page":"1322-1332","source":"Crossref","is-referenced-by-count":23,"title":["Diabetes mellitus: association of cystatin C- versus creatinine-based estimated glomerular filtration rate with mortality and cardiovascular events"],"prefix":"10.1093","volume":"39","author":[{"given":"Daijun","family":"He","sequence":"first","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital , 8 Xishiku Street, Xicheng District, Beijing , China"},{"name":"Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of , Beijing , China"},{"name":"Health of China; and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education , Beijing , China"},{"name":"Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixia","family":"Gao","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University First Hospital , 8 Xishiku Street, Xicheng District, Beijing , China"},{"name":"Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of , Beijing , China"},{"name":"Health of China; 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