{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:22:31Z","timestamp":1793110951077,"version":"4.5.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304948"],"award-info":[{"award-number":["82304948"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation in Minhang District of Shanghai","award":["2022MHZ004"],"award-info":[{"award-number":["2022MHZ004"]}]},{"name":"Research project of Shanghai Minhang District Health Committee","award":["2022MW13"],"award-info":[{"award-number":["2022MW13"]}],"id":[{"id":"https:\/\/ror.org\/00wc5dh73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Minhang District High-Level Specialty Key Physician Training Program","award":["2020MZYS19"],"award-info":[{"award-number":["2020MZYS19"]}]},{"name":"Minhang District Medical Characteristic Specialty Project","award":["2020MWTZB07"],"award-info":[{"award-number":["2020MWTZB07"]}]},{"name":"Hospital-level Discipline-Chronic Disease Group-Chronic Kidney Disease Project","award":["YJXK-2021-13"],"award-info":[{"award-number":["YJXK-2021-13"]}]},{"name":"Jiangsu Provincial Medical Innovation Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,27]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immunoglobulin A nephropathy (IgAN) is a major cause of primary glomerulonephritis characterized by mesangial deposits of galactose-deficient IgA1 (Gd-IgA1). Toll-like receptors (TLRs), particularly TLR4, are involved in the pathogenesis of IgAN. The role of gut microbiota on IgAN patients was recently investigated. However, whether gut microbial modifications of Gd-IgA1 through TLR4 play a role in IgAN remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited subjects into four groups, including 48 patients with untreated IgAN, 22 treated IgAN patients (IgANIT), 22 primary membranous nephropathy and 31 healthy controls (HCs). Fecal samples were collected to analyze changes in gut microbiome. Gd-IgA1 levels, expression of TLR4, B-cell stimulators and intestinal barrier function were evaluated in all subjects. C57BL\/6 mice were treated with a broad-spectrum antibiotic cocktail to deplete the gut microbiota and then gavaged with fecal microbiota transplanted from clinical subjects of every group. Gd-IgA1 and TLR4 pathway were detected in peripheral blood mononuclear cells (PBMCs) from IgAN and HCs co-incubated with lipopolysaccharide (LPS) and TLR4 inhibitor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the other three groups, different compositions and decreased diversity demonstrated gut dysbiosis in the untreated IgAN group, especially the enrichment of Escherichia-Shigella. Elevated Gd-IgA1 levels were found in untreated IgAN patients and correlated with gut dysbiosis, TLR4, B-cell stimulators, indexes of intestinal barrier damage and proinflammatory cytokines. In vivo, mice colonized with gut microbiota from IgAN and IgANIT patients mimicked the IgAN phenotype with the activation of TLR4\/MyD88\/nuclear factor-\u03baB pathway and B-cell stimulators in the intestine, and had with enhanced proinflammatory cytokines. In vitro, LPS activated TLR4\/MyD88\/NF-\u03baB pathway, B-cell stimulators and proinflammatory cytokines in PBMCs of IgAN patients. This process may induce the overproduction of Gd-IgA1, which was inhibited by TLR4 inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results illustrated that the gut\u2013kidney axis is involved in the pathogenesis of IgAN. Gut dysbiosis could stimulate the overproduction of Gd-IgA1 via TLR4 signaling pathway production and B-cell stimulators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfae052","type":"journal-article","created":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T04:57:07Z","timestamp":1708837027000},"page":"1624-1641","source":"Crossref","is-referenced-by-count":61,"title":["IgA nephropathy: gut microbiome regulates the production of hypoglycosilated IgA1 via the TLR4 signaling pathway"],"prefix":"10.1093","volume":"39","author":[{"given":"Yifan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Minhang Hospital, Fudan University , Shanghai ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Minhang Hospital, Fudan University , Shanghai ,","place":["P.R. 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