{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:02:24Z","timestamp":1778594544763,"version":"3.51.4"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170739"],"award-info":[{"award-number":["82170739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Primary immunodeficiency (PID) is no longer defined by infections alone, and autoimmunity is an accompanying manifestation of PID. Recurrent infections may trigger autoimmunity through molecular mimicry, bystander activation or superantigens. The diagnosis of PID is still challenging, but genetic analysis reveals the underlying link between PID and autoimmunity. Mutations in relevant genes affecting central and peripheral immune tolerance, regulatory T-cell function, expansion of autoreactive lymphocytes, antigen clearance, hyperactivation of type I interferon and nuclear factor-\u03baB pathways have all been implicated in triggering autoimmunity in PID. Autoimmunity in PID leads to chronic inflammation, tissue damage and organ failure, and increases the mortality of patients with PID. The kidneys are inextricably linked with the immune system, and kidney diseases can be mediated by both infection and autoimmunity\/inflammation in PID patients. The manifestations of kidney involvement in PID patients are very heterogeneous and include lupus nephritis, C3 glomerulopathy, kidney thrombotic microangiopathy, vasculitis and interstitial nephritis. Patients with PID-caused kidney diseases have defined immune function defects and may benefit from pathway-based biologics, stem cell transplantation or gene therapy. Early diagnosis and appropriate treatment of PID are crucial for reducing the mortality rate and improving organ function and quality of life.<\/jats:p>","DOI":"10.1093\/ndt\/gfae117","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T01:33:56Z","timestamp":1716341636000},"page":"1772-1784","source":"Crossref","is-referenced-by-count":5,"title":["Primary immunodeficiency as a cause of immune-mediated kidney diseases"],"prefix":"10.1093","volume":"39","author":[{"given":"Changming","family":"Zhang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Liang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-0726","authenticated-orcid":false,"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Diseases, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"2024103010311360500_bib1","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1007\/s10875-022-01289-3","article-title":"Human inborn errors of immunity: 2022 update on the classification from the International Union of Immunological Societies Expert Committee","volume":"42","author":"Tangye","year":"2022","journal-title":"J Clin Immunol"},{"key":"2024103010311360500_bib2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrrheum.2017.198","article-title":"Autoimmunity and primary immunodeficiency: two sides of the same coin?","volume":"14","author":"Schmidt","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"2024103010311360500_bib3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jaut.2019.01.011","article-title":"Primary immunodeficiency and autoimmunity: a comprehensive review","volume":"99","author":"Amaya-Uribe","year":"2019","journal-title":"J Autoimmun"},{"key":"2024103010311360500_bib4","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1097\/MOP.0000000000000833","article-title":"Autoimmunity as a continuum in primary immunodeficiency","volume":"31","author":"Walter","year":"2019","journal-title":"Curr Opin Pediatr"},{"key":"2024103010311360500_bib5","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.jaci.2016.12.978","article-title":"Autoimmune and inflammatory manifestations occur frequently in patients with primary immunodeficiencies","volume":"140","author":"Fischer","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"2024103010311360500_bib6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1159\/000529917","article-title":"Kidney involvement in autoinflammatory diseases","volume":"9","author":"Zhang","year":"2023","journal-title":"Kidney Dis"},{"key":"2024103010311360500_bib7","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1016\/j.jaip.2023.04.018","article-title":"Inborn errors of immunity and autoimmune disease","volume":"11","author":"Gray","year":"2023","journal-title":"Allergy Clin Immunol Prac"},{"key":"2024103010311360500_bib8","doi-asserted-by":"publisher","first-page":"869","DOI":"10.2215\/CJN.0000000000000185","article-title":"Pathogenic gene spectrum and clinical implication in Chinese patients with lupus nephritis","volume":"18","author":"Zhang","year":"2023","journal-title":"Clin J Am Soc Nephrol"},{"key":"2024103010311360500_bib9","doi-asserted-by":"publisher","first-page":"928062","DOI":"10.3389\/fimmu.2022.928062","article-title":"Secondary immune deficiency and primary immune deficiency crossovers: hematological malignancies and autoimmune diseases","volume":"13","author":"Ballow","year":"2022","journal-title":"Front Immunol"},{"key":"2024103010311360500_bib10","doi-asserted-by":"publisher","first-page":"491","DOI":"10.34067\/KID.0000432020","article-title":"Renal Manifestations of common variable immunodeficiency","volume":"1","author":"Caza","year":"2020","journal-title":"Kidney360"},{"key":"2024103010311360500_bib11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/cei\/uxac056","article-title":"The yin and the yang of early classical pathway complement disorders","volume":"209","author":"Sullivan","year":"2022","journal-title":"Clin Exp Immunol"},{"key":"2024103010311360500_bib12","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1007\/s10875-023-01579-4","article-title":"Phenotypic variability in PRKCD: a review of the literature","volume":"43","author":"Jefferson","year":"2023","journal-title":"J Clin Immunol"},{"key":"2024103010311360500_bib13","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1002\/art.38008","article-title":"Protein kinase c\u03b4 deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation","volume":"65","author":"Belot","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2024103010311360500_bib14","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1182\/blood-2012-10-460741","article-title":"B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C \u03b4","volume":"121","author":"Salzer","year":"2013","journal-title":"Blood"},{"key":"2024103010311360500_bib15","doi-asserted-by":"publisher","first-page":"e20160781","DOI":"10.1542\/peds.2016-0781","article-title":"Early-onset juvenile SLE associated with a novel mutation in protein kinase C \u03b4","volume":"139","author":"Nanthapisal","year":"2017","journal-title":"Pediatrics"},{"key":"2024103010311360500_bib16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12969-018-0278-1","article-title":"Successful use of ofatumumab in two cases of early-onset juvenile SLE with thrombocytopenia caused by a mutation in protein kinase C \u03b4","volume":"16","author":"Lei","year":"2018","journal-title":"Pediatr Rheumatol"},{"key":"2024103010311360500_bib17","doi-asserted-by":"publisher","first-page":"e201","DOI":"10.1038\/s41424-018-0064-x","article-title":"Clinical heterogeneity of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a French multicenter retrospective study","volume":"9","author":"Duclaux-Loras","year":"2018","journal-title":"Clin Transl Gastroenterol"},{"key":"2024103010311360500_bib18","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12882-022-02999-x","article-title":"Granulomatous interstitial nephritis with CTLA-4 haploinsufficiency: a case report","volume":"23","author":"Kohatsu","year":"2022","journal-title":"BMC Nephrol"},{"key":"2024103010311360500_bib19","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.jaci.2022.09.002","article-title":"Monogenic early-onset lymphoproliferation and autoimmunity: natural history of STAT3 gain-of-function syndrome","volume":"151","author":"Leiding","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"2024103010311360500_bib20","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/s41573-019-0041-4","article-title":"Next-generation regulatory T cell therapy","volume":"18","author":"Ferreira","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"2024103010311360500_bib21","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.kint.2022.02.031","article-title":"Type I interferon-related kidney disorders","volume":"101","author":"Lodi","year":"2022","journal-title":"Kidney Int"},{"key":"2024103010311360500_bib22","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1136\/annrheumdis-2018-213028","article-title":"Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-alpha in lupus nephritis","volume":"77","author":"Qi","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2024103010311360500_bib23","doi-asserted-by":"publisher","first-page":"3116","DOI":"10.4049\/jimmunol.1101313","article-title":"Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing","volume":"188","author":"Simmons","year":"2012","journal-title":"J Immunol"},{"key":"2024103010311360500_bib24","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1073\/pnas.1005201108","article-title":"Recruited inflammatory monocytes stimulate antiviral Th1 immunity in infected tissue","volume":"108","author":"Iijima","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024103010311360500_bib25","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1093\/rheumatology\/keu249","article-title":"Interferon-alpha-induced B-lymphocyte stimulator expression and mobilization in healthy and systemic lupus erthymatosus monocytes","volume":"53","author":"Lopez","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"2024103010311360500_bib26","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"Baff mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J Exp Med"},{"key":"2024103010311360500_bib27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF and APRIL: a tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"2024103010311360500_bib28","doi-asserted-by":"publisher","first-page":"1050528","DOI":"10.3389\/fimmu.2023.1050528","article-title":"B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease","volume":"14","author":"Giordano","year":"2023","journal-title":"Front Immunol"},{"key":"2024103010311360500_bib29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13075-018-1568-1","article-title":"Dysregulated heme oxygenase-1(low) M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons","volume":"20","author":"Kishimoto","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"2024103010311360500_bib30","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1038\/ng.975","article-title":"Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus","volume":"43","author":"Al-Mayouf","year":"2011","journal-title":"Nat Genet"},{"key":"2024103010311360500_bib31","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/ng2091","article-title":"Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus","volume":"39","author":"Lee-Kirsch","year":"2007","journal-title":"Nat Genet"},{"key":"2024103010311360500_bib32","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1053\/j.ajkd.2018.05.006","article-title":"TREX1 mutation causing autosomal dominant thrombotic microangiopathy and CKD-a novel presentation","volume":"72","author":"Gulati","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"2024103010311360500_bib33","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1681\/ASN.2022040477","article-title":"Clinical implications of a new DDX58 pathogenic variant that causes lupus nephritis due to RIG-I hyperactivation","volume":"34","author":"Peng","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"2024103010311360500_bib34","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1038\/s41467-022-29946-6","article-title":"Deficiency in coatomer complex I causes aberrant activation of STING signalling","volume":"13","author":"Steiner","year":"2022","journal-title":"Nat Commun"},{"key":"2024103010311360500_bib35","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/ng.748","article-title":"Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature","volume":"43","author":"Briggs","year":"2011","journal-title":"Nat Genet"},{"key":"2024103010311360500_bib36","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.1038\/s41467-020-18925-4","article-title":"Early-onset autoimmunity associated with SOCS1 haploinsufficiency","volume":"11","author":"Hadjadj","year":"2020","journal-title":"Nat Commun"},{"key":"2024103010311360500_bib37","doi-asserted-by":"publisher","first-page":"103119","DOI":"10.1016\/j.jaut.2023.103119","article-title":"In cis \u201cbenign\u201d SOCS1 variants linked to enhanced interferon signaling and autoimmunity","volume":"140","author":"Du","year":"2023","journal-title":"J Autoimmun"},{"key":"2024103010311360500_bib38","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1053\/j.ajkd.2019.07.010","article-title":"APOL1-associated collapsing focal segmental glomerulosclerosis in a patient with Stimulator of Interferon Genes (STING)-Associated Vasculopathy with onset in Infancy (SAVI)","volume":"75","author":"Abid","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"2024103010311360500_bib39","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1053\/j.ajkd.2021.02.330","article-title":"Collapsing glomerulopathy as a complication of type I interferon-mediated glomerulopathy in a patient with RNASEH2B-related Aicardi\u2013Goutieres syndrome","volume":"78","author":"Fenaroli","year":"2021","journal-title":"Am J Kidney Dis"},{"key":"2024103010311360500_bib40","doi-asserted-by":"publisher","first-page":"5234","DOI":"10.3390\/ijms242015234","article-title":"The role of the oxidative state and innate immunity mediated by TLR7 and TLR9 in lupus nephritis","volume":"24","author":"Echavarria","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024103010311360500_bib41","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41586-022-04642-z","article-title":"TLR7 gain-of-function genetic variation causes human lupus","volume":"605","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"2024103010311360500_bib42","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/ng.3459","article-title":"Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease","volume":"48","author":"Zhou","year":"2016","journal-title":"Nat Genet"},{"key":"2024103010311360500_bib43","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1093\/ckj\/sfac130","article-title":"Novel loss-of-function mutations in TNFAIP3 gene in patients with lupus nephritis","volume":"15","author":"Zhang","year":"2022","journal-title":"Clin Kidney J"},{"key":"2024103010311360500_bib44","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1007\/s10875-020-00754-1","article-title":"European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management","volume":"40","author":"Brodszki","year":"2020","journal-title":"J Clin Immunol"},{"key":"2024103010311360500_bib45","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.coi.2012.08.004","article-title":"Complement, interferon and lupus","volume":"24","author":"Elkon","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"2024103010311360500_bib46","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1002\/art.40158","article-title":"Brief report: deficiency of complement 1r subcomponent in early-onset systemic lupus erythematosus: the role of disease-modifying alleles in a monogenic disease","volume":"69","author":"Demirkaya","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2024103010311360500_bib47","doi-asserted-by":"publisher","first-page":"942","DOI":"10.2215\/CJN.11830720","article-title":"Inherited kidney complement diseases","volume":"16","author":"Lemaire","year":"2021","journal-title":"Clin J Am Soc Nephrol"},{"key":"2024103010311360500_bib48","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1681\/ASN.2019050515","article-title":"CFHR gene variations provide insights in the pathogenesis of the kidney diseases atypical hemolytic uremic syndrome and C3 glomerulopathy","volume":"31","author":"Zipfel","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"2024103010311360500_bib49","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1182\/bloodadvances.2018019596","article-title":"Complement-mediated thrombotic microangiopathy associated with lupus nephritis","volume":"2","author":"Park","year":"2018","journal-title":"Blood Adv"},{"key":"2024103010311360500_bib50","article-title":"Schimke immunoosseous dysplasia","volume-title":"GeneReviews\u00ae","author":"Lippner","year":"1993"},{"key":"2024103010311360500_bib51","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/1871530319666190828125316","article-title":"Diagnostic approach to the patients with suspected primary immunodeficiency","volume":"20","author":"Tavakol","year":"2020","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"2024103010311360500_bib52","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1016\/j.jaci.2015.04.049","article-title":"Practice parameter for the diagnosis and management of primary immunodeficiency","volume":"136","author":"Bonilla","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"2024103010311360500_bib53","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jaip.2022.10.003","article-title":"The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity","volume":"11","author":"Baris","year":"2023","journal-title":"Allergy Clin Immunol Prac"},{"key":"2024103010311360500_bib54","doi-asserted-by":"publisher","first-page":"94","DOI":"10.12688\/f1000research.21553.1","article-title":"Recent advances in primary immunodeficiency: from molecular diagnosis to treatment","volume":"9","author":"Bucciol","year":"2020","journal-title":"F1000Res"},{"key":"2024103010311360500_bib55","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.jaci.2019.11.020","article-title":"Janus kinase inhibition for autoinflammation in patients with DNASE2 deficiency","volume":"145","author":"Hong","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2024103010311360500_bib56","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1001\/jamadermatol.2018.5077","article-title":"Assessment of clinical response to Janus kinase inhibition in patients with familial chilblain lupus and TREX1 mutation","volume":"155","author":"Zimmermann","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2024103010311360500_bib57","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1056\/NEJMc2001362","article-title":"Janus kinase inhibition in the Aicardi\u2013Goutieres syndrome","volume":"383","author":"Vanderver","year":"2020","journal-title":"N Engl J Med"},{"key":"2024103010311360500_bib58","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3389\/fimmu.2020.00985","article-title":"Interstitial lung disease and psoriasis in a child with Aicardi\u2013Goutieres syndrome","volume":"11","author":"Zheng","year":"2020","journal-title":"Front Immunol"},{"key":"2024103010311360500_bib59","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1136\/annrheumdis-2021-221478","article-title":"Phase II randomised trial of type I interferon inhibitor anifrolumab in patients with active lupus nephritis","volume":"81","author":"Jayne","year":"2022","journal-title":"Ann Rheum Dis"},{"key":"2024103010311360500_bib60","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12881-019-0856-1","article-title":"Expanding the spectrum of A20 haploinsufficiency in two Chinese families: cases report","volume":"20","author":"Li","year":"2019","journal-title":"BMC Med Genet"},{"key":"2024103010311360500_bib61","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1136\/annrheumdis-2017-212403","article-title":"A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease","volume":"77","author":"Aeschlimann","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2024103010311360500_bib62","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1136\/annrheumdis-2016-210944","article-title":"Early-onset autoimmune disease due to a heterozygous loss-of-function mutation in TNFAIP3 (A20)","volume":"77","author":"Duncan","year":"2018","journal-title":"Ann Rheum Dis"}],"container-title":["Nephrology Dialysis Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ndt\/advance-article-pdf\/doi\/10.1093\/ndt\/gfae117\/58232384\/gfae117.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/39\/11\/1772\/60179114\/gfae117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ndt\/article-pdf\/39\/11\/1772\/60179114\/gfae117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:56:20Z","timestamp":1730296580000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ndt\/article\/39\/11\/1772\/7679144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":62,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,5,21]]},"published-print":{"date-parts":[[2024,10,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ndt\/gfae117","relation":{},"ISSN":["0931-0509","1460-2385"],"issn-type":[{"value":"0931-0509","type":"print"},{"value":"1460-2385","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,5,21]]}}}