{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:39:51Z","timestamp":1787618391727,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970599"],"award-info":[{"award-number":["81970599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170737"],"award-info":[{"award-number":["82170737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370707"],"award-info":[{"award-number":["82370707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018684","name":"National Health Commission","doi-asserted-by":"publisher","award":["2002B60118"],"award-info":[{"award-number":["2002B60118"]}],"id":[{"id":"10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018684","name":"National Health Commission","doi-asserted-by":"publisher","award":["2020B1212060028"],"award-info":[{"award-number":["2020B1212060028"]}],"id":[{"id":"10.13039\/501100018684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>No studies have explored the long-term outcomes of neural cell adhesion molecule 1 (NCAM1)-associated membranous lupus nephritis (MLN) patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>We performed immunohistochemical studies on kidney biopsy specimens against NCAM1 in consecutive MLN patients. The clinical and histopathological characteristics and outcomes of cases of NCAM1-associated MLN patients are described and compared with NCAM1-negative patients. In addition, we detected serum circulating anti-NCAM1 antibodies through western blotting and indirect immunofluorescence assays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 361 MLN cases, 18 (5.0%) were glomerular NCAM1-positive. NCAM1-positive MLN patients were older [35 years (interquartile range, IQR 27\u201343) versus 28 (22\u201337); P\u00a0=\u00a0.050] and had lower systemic lupus erythematosus disease activity index [11 (IQR 8\u201312) versus 14 (10\u201318); P\u00a0=\u00a0.007], serum creatinine [60 \u03bcmol\/L (IQR 50\u201370) versus 70 (54\u2013114); P\u00a0=\u00a0.029] and activity index [3 (IQR 2\u20136) versus 6 (3\u20139); P\u00a0=\u00a0.045] at kidney biopsy compared with NCAM1-negative patients. The percentage of positive anti-Sj\u00f6gren's syndrome\u2013related antigen A antibodies in NCAM1-positive patients was significantly greater (83.3% versus 58.2%; P\u00a0=\u00a0.035) than in the NCAM1-negative patients. However, no evidence of neuropsychiatric disorders was found in these 18 patients. There were no significant differences in the treatment response and the risk of end-stage renal diseases between NCAM1-positive and -negative groups (P\u00a0=\u00a0.668 and P\u00a0=\u00a0.318, respectively). However, the risk of death was much higher in the NCAM1-positive group than the NCAM1-negative group (27.8% vs 8.1%; P\u00a0=\u00a0.007). Moreover, the risk of death was also much higher in the NCAM1-positive group than the matched NCAM1-negative group (Log-rank P\u00a0=\u00a0.013). Additionally, circulating anti-NCAM1 antibodies can be detected in 1\/5 (20%) patients who had serum available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The prevalence of NCAM1 positivity was 5.0% in our cohort of MLN and the high mortality in these subgroup patients are needed to validate in future studies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ndt\/gfae148","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T12:32:19Z","timestamp":1720614739000},"page":"193-205","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathological phenotype and outcomes of NCAM-1+ membranous lupus nephritis"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-5567","authenticated-orcid":false,"given":"Xi","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Nephrology, The First 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