{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:56:32Z","timestamp":1775786192087,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National High Level Hospital Clinical Research","award":["2022CR20"],"award-info":[{"award-number":["2022CR20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between superimposed preeclampsia and an elevated risk of long-term kidney function decline or end-stage kidney disease (ESKD) in patients with chronic kidney disease (CKD) has not been determined. This study aimed to analyze the association between preeclampsia and kidney function deterioration in CKD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study that included the clinical information of 103 pregnant CKD patients with preeclampsia and 103 matched CKD patients without preeclampsia who were followed-up for a minimum of 1\u00a0year after their first pregnancy from 1 January 2009 to 31 May 2022. Robust Cox regression analysis was also conducted to evaluate the effects of preeclampsia on long-term kidney function decline or ESKD in CKD patients. Kaplan\u2013Meier curves were used to compare renal survival within different subgroups via the log-rank test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the follow-up period, 44 (42.72%) CKD patients with preeclampsia and 20 (19.42%) without preeclampsia had an estimated glomerular filtration rate (eGFR) decrease &amp;gt;30% or developed ESKD. Compared with CKD patients without preeclampsia, the eGFR decreased more significantly in patients with preeclampsia [98.43 (79.48, 116.47) to 81.32 (41.20, 102.97) mL\/min\/1.73\u00a0m2 vs 99.43 (79.00, 118.50) to 89.44 (63.69, 105.30) mL\/min\/1.73\u00a0m2; P\u00a0=\u00a0.034]. The rate of eGFR decrease was more pronounced in patients with preeclampsia (17.38% vs 10.05%, P\u00a0&amp;lt;\u00a0.05). Multivariate analysis revealed that early-onset preeclampsia (preeclampsia that developed before 34\u00a0weeks of gestation) [hazard ratio (HR)\u00a0=\u00a02.61, 95% confidence interval (CI) 1.32\u20135.16, P\u00a0=\u00a00.006] and late-onset preeclampsia (HR\u00a0=\u00a02.54, 95% CI 1.34\u20134.83, P\u00a0=\u00a0.004) were both risk factors for an eGFR decrease &amp;gt;30% or ESKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preeclampsia was associated with a greater risk of long-term kidney function decline or ESKD among CKD patients, especially in patients with early-onset preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ndt\/gfae172","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T23:12:23Z","timestamp":1721257943000},"page":"393-404","source":"Crossref","is-referenced-by-count":3,"title":["The effect of preeclampsia on long-term kidney function among pregnant women with chronic kidney disease"],"prefix":"10.1093","volume":"40","author":[{"given":"Zheng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University, First Hospital , Beijing ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Peking University, First Hospital , Beijing ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Tan","sequence":"additional","affiliation":[{"name":"Renal Division, Department of Medicine, Peking University, First Hospital ; , Beijing ,","place":["PR China"]},{"name":"Peking University Institute of Nephrology ; , Beijing ,","place":["PR 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